Results 141 to 150 of about 24,851,358 (308)

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Disturbance Observer-Based Fixed-Time Sliding-Mode Control for Electromechanical Actuators

Actuators
Electromechanical actuators play a pivotal role in aerospace servo systems; however, their high-precision tracking performance is frequently compromised by external disturbances and system nonlinearities.
Xi Xiao, Ziyang Zhen, Huanyu Sun
doaj   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Fixed-Time Disturbance Rejection Attitude Control for a Dual-System Hybrid UAV

Drones
The hybrid unmanned aerial vehicle combines the vertical take-off and landing and hover abilities of rotary-wing UAVs with the high-speed cruise and long-endurance capabilities of fixed-wing UAVs, expanding the flight envelope and application areas.
Wenyu Chen, Lulu Chen, Zhenbao Liu, Qingqing Dang, Wen Zhao, Tao Zhang, Chao Ma   +6 more
doaj   +1 more source

Adaptive traffic signal control using approximate dynamic programming [PDF]

, 2009
This paper presents a study on an adaptive traffic signal controller for real-time operation. The controller aims for three operational objectives: dynamic allocation of green time, automatic adjustment to control parameters, and fast revision of signal ...
Heydecker, B.G., Cai, C., Wong, C.K.
core  

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source

Adaptive fixed-time fuzzy containment control for uncertain nonlinear multiagent systems with unmeasurable states

Scientific Reports
This paper addresses the adaptive fixed-time fuzzy containment control for uncertain nonlinear multiagent systems, where the states and nonlinear functions are not feasible for the controller design.
Ruixia Liu, Lei Xing, Yongjian Zhong, Hong Deng, Weichao Zhong   +4 more
doaj   +1 more source

Robust fixed-time flight controller for a dual-system convertible UAV in the cruise mode

Defence Technology
This paper investigates the attitude tracking control problem for the cruise mode of a dual-system convertible unmanned aerial vehicle (UAV) in the presence of parameter uncertainties, unmodeled uncertainties and wind disturbances.
Lulu Chen, Zhenbao Liu, Qingqing Dang, Wen Zhao, Wenyu Chen   +4 more
doaj   +1 more source