Results 131 to 140 of about 24,851,358 (308)
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Fixed-time formation behavior control for unmanned ground vehicle-manipulators
Scientific ReportsUnmanned ground vehicle-manipulators (UGVMs), which integrate mobility and dexterous manipulation, are increasingly deployed in complex environments. However, their formation control is challenged by nonholonomic constraints, external disturbances, and ...
Wenyan Xue +3 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
Fault-Tolerant Control of Multi-Clamp Disc Elevator Brakes with Fixed-Time Convergence
This paper proposes a passive fault-tolerant control strategy for a multi-caliper disc elevator brake system subject to unknown external disturbances and multiple actuator faults. Initially, a detailed analysis of the dynamic equations of the actuator in
Yuan Zhou +4 more
core +1 more source
The microbiome in human skin aging
FEBS Letters, EarlyView.Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana +3 more
wiley +1 more source
The effects of delay-to-reinforcement, response requirement and schedule duration on performance under fixed-ratio schedules [PDF]
, 2011 Experiment 1 examined the effects of delay-to-reinforcement on between-ratio pausing in multiple fixed-ratio 5 fixed-ratio 5 schedules. In one component the reinforcer was delivered immediately on completion of the ratio, and in the other there was a ...
Harris, Aimee Rebecca
core
FEBS Letters, EarlyView.This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee +2 more
wiley +1 more source
Load frequency control is essential for maintaining power system stability, especially under uncertainties and input delays. This paper proposes a reinforcement learning-based dual-channel dynamic event-triggered fixed-time load frequency control ...
Zhao, Huarong +4 more
core +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source
This study explores the issue of fixed-time dynamic event-triggered consensus control for uncertain nonlinear multi-agent systems (MASs) within directed graph frameworks.
Zian Wang +6 more
core +1 more source