Results 121 to 130 of about 24,851,358 (308)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Attitude Control of Over-Actuated Fixed-Wing Aircraft Based on Predefined Time Control

Aerospace
This paper presents a novel predefined-time attitude-control framework for fixed-wing aircraft with over-actuated systems, solving aerodynamic uncertainties and nonlinear couplings during high-angle-of-attack flight. The proposed methodology integrates a
Fangping Chen, Pengfei Li, Hainuo Chen, Xuebin Ni, Jingjing Pan, Tingting Guo, Limin Bai, Junying Ma, Qu Wang   +8 more
doaj   +1 more source

Fixed-Time Gradient Dynamics With Time-Varying Coefficients for Continuous-Time Optimization

, 2023
In this article, we propose fixed-time gradient dynamics with time-varying coefficients for continuous-time optimization. We first investigate the Lyapunov stability conditions that allow us to achieve fixed-time stability of the time-varying dynamical ...
Xinghuo Yu (18029455), Andrew Eberhard (18026932), Thuy Lien Nguyen (18306094), Chaojie Li (815056)   +3 more
core  

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Fixed-Time Event-Triggered Control for Distributed Unmanned Underwater Vehicles

Journal of Marine Science and Engineering
This paper investigates the problem of fixed-time event-triggered consensus control for distributed unmanned underwater vehicle systems subject to communication and energy constraints. The systematic integration control framework is developed, where each
Xiaoling Liang, Jie Li, Dan Bao
doaj   +1 more source

A Disturbance Observer-Based Fractional-Order Fixed-Time Sliding Mode Control Approach for Elevators

For elevators, appropriate speed control is pivotal for ensuring the safety and comfort of passengers and optimizing energy efficiency, system stability, and service life. Therefore, the design and implementation of effective speed control strategies are
Zhe Sun, Huaqing Liu, Wanbin Su, Bo Chen, Ke Li, Yefeng Jiang   +5 more
core   +1 more source