Results 231 to 240 of about 5,130,677 (338)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Model-free adaptive fixed-time prescribed performance control for PEMFC air feeding system based on oxygen excess ratio reconstruction. [PDF]

Sci Rep
Mohammed OAA, Xiong S, Qingsheng L, Kai M, Wang H, Yakubu AU, Hamid GHA, Ishag AM.   +7 more
europepmc   +1 more source

Prospective controlled study comparing 5.5-mm long implants with longer implants to support fixed partial prosthesis in the premolar-molar regions: 12 months follow-up. [PDF]

BDJ Open
Anitua E, Montalvillo A, Alkhraisat MH.
europepmc   +1 more source

Steric regulation of CRISPR/Cas12a trans-cleavage kinetics via split-activator extensions. [PDF]

Nucleic Acids Res
Zhang J, He X, Huang J, Cheng C, He G, Xia R, Yang J, Chen J, Guo L, Xiang D, Li F, Shi J, Li P.   +12 more
europepmc   +1 more source

Trajectory Tracking Control for Subsea Mining Vehicles Based on Fuzzy PID Optimised by Genetic Algorithms. [PDF]

Sensors (Basel)
Bu H, Wu M, Liu B, Yan Z.
europepmc   +1 more source

Prenatal Stress and Prenatal Alcohol Alter the Adult Dopamine System and Alcohol Consumption: Dopamine Drives Drinking Behavior in a Prospective 20-Year Longitudinal Experiment with Rhesus Macaques. [PDF]

J Neurosci
Converse AK, Ahlers EO, Barnhart TE, Christian BT, DeJesus OT, Engle JW, Holden JE, Larson JA, Moirano JM, Murali D, Nickles RJ, Resch LM, Moore CF, Schneider ML.   +13 more
europepmc   +1 more source

Rhodnius prolixus impairs Trypanosoma cruzi growth through cold-seeking behavioral thermoregulation. [PDF]

PLoS Negl Trop Dis
Loshouarn H, Guarneri AA.
europepmc   +1 more source

Effects of Using a Smartphone App Combined With Behavior Change Techniques on the Level of Physical Activity Among Adults and Older Adults: Sequential Multiple Assignment Randomized Trial.

J Med Internet Res
Simoes MDSMP, Proença NL, Lauria VT, do Nascimento MB, Padovani RDC, Dourado VZ.   +5 more
europepmc   +1 more source

Ambient Artificial Intelligence Scribes and Physician Financial Productivity.

JAMA Netw Open
Holmgren AJ, Fenton CL, Thombley R, Soleimani H, Croci R, DeMasi O, Byron ME, Murray SG, Adler-Milstein JR, Yazdany J.   +9 more
europepmc   +1 more source