Results 81 to 90 of about 560,761 (277)

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Escape Criterion Using Fixed Point Iteration with Applications in Fractal Generation [PDF]

International Journal of Mathematical, Engineering and Management Sciences
This study employs the Picard-S3 iteration method, which proves to be particularly useful for visualizing and examining fractals, as well as investigating intricate dynamical systems. In the present paper, we focus on the complex polynomial function.
Sanjay Kumar Padaliya , Saurabh Sharma, Gaurav Semwal , Vijay Kumar   +3 more
doaj   +1 more source

Targeting p38α in cancer: challenges, opportunities, and emerging strategies

Molecular Oncology, EarlyView.
p38α normally regulates cellular stress responses and homeostasis and suppresses malignant transformation. In cancer, however, p38α is co‐opted to drive context‐dependent proliferation and dissemination. p38α also supports key functions in cells of the tumor microenvironment, including fibroblasts, myeloid cells, and T lymphocytes.
Angel R. Nebreda
wiley   +1 more source

Hybrid Inertial Self-Adaptive Iterative Methods for Split Variational Inclusion Problems

Axioms
Herein, we present two hybrid inertial self-adaptive iterative methods for determining the combined solution of the split variational inclusions and fixed-point problems.
Doaa Filali, Mohammad Dilshad, Atiaf Farhan Yahya Alfaifi, Mohammad Akram   +3 more
doaj   +1 more source

Fast Solvers for Unsteady Thermal Fluid Structure Interaction

, 2014
We consider time dependent thermal fluid structure interaction. The respective models are the compressible Navier-Stokes equations and the nonlinear heat equation. A partitioned coupling approach via a Dirichlet-Neumann method and a fixed point iteration
Birken, Philipp, Gleim, Tobias, Kuhl, Detlef, Meister, Andreas   +3 more
core  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Strong Convergence Theorems for a Countable Family of Nonexpansive Mappings in Convex Metric Spaces

Abstract and Applied Analysis, 2011
We introduce a new modified Halpern iteration for a countable infinite family of nonexpansive mappings {Tn} in convex metric spaces. We prove that the sequence {xn} generated by the proposed iteration is an approximating fixed point sequence of a ...
Withun Phuengrattana, Suthep Suantai
doaj   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Strongly Convergence of Two Iterations For a Common Fixed Point with an Application

Ibn Al-Haitham Journal for Pure and Applied Sciences, 2019
     In this paper, we study some cases of a common fixed point theorem for classes of firmly nonexpansive and generalized nonexpansive maps. In addition, we establish that the Picard-Mann iteration is faster than Noor iteration and we used Noor ...
Zahra Mahmood Mohamed Hasan, Salwa Salman Abed   +1 more
doaj   +1 more source

RaMBat: Accurate identification of medulloblastoma subtypes from diverse data sources with severe batch effects

Molecular Oncology, EarlyView.
To integrate multiple transcriptomics data with severe batch effects for identifying MB subtypes, we developed a novel and accurate computational method named RaMBat, which leveraged subtype‐specific gene expression ranking information instead of absolute gene expression levels to address batch effects of diverse data sources.
Mengtao Sun, Jieqiong Wang, Shibiao Wan
wiley   +1 more source