Results 1 to 10 of about 98,100 (165)
InterAKTions with FKBPs--mutational and pharmacological exploration. [PDF]
PLoS ONE, 2013 The FK506-binding protein 51 (FKBP51) is an Hsp90-associated co-chaperone which regulates steroid receptors and kinases. In pancreatic cancer cell lines, FKBP51 was shown to recruit the phosphatase PHLPP to facilitate dephosphorylation of the kinase Akt,
Anne-Katrin Fabian +5 more
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Steric confinement-induced emission probe for monitoring protein conformations in live cells [PDF]
Communications ChemistryProtein conformational changes drive signal transduction to regulate cellular activities, yet monitoring of these changes in living cells remains challenging.
Huixia Jia +8 more
doaj +2 more sources
Cells, 2022 Intracellular peptides (InPeps) generated by proteasomes were previously suggested as putative natural regulators of protein–protein interactions (PPI).
Carolina A. Parada +12 more
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Functional identification of a Streptomyces lividans FKBP-like protein involved in the folding of overproduced secreted proteins [PDF]
Open Biology, 2019 Some bacterial peptidyl-prolyl cis/trans isomerases (PPIases) are involved in secretory protein folding after the translocation step. Streptomyces lividans has been used as a host for engineering extracellular overproduction of homologous and ...
R. L. Vicente +5 more
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The free energy landscape of small molecule unbinding. [PDF]
PLoS Computational Biology, 2011 The spontaneous dissociation of six small ligands from the active site of FKBP (the FK506 binding protein) is investigated by explicit water molecular dynamics simulations and network analysis.
Danzhi Huang, Amedeo Caflisch
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RyR1-targeted drug discovery pipeline integrating FRET-based high-throughput screening and human myofiber dynamic Ca2+ assays. [PDF]
, 2020 Elevated cytoplasmic [Ca2+] is characteristic in severe skeletal and cardiac myopathies, diabetes, and neurodegeneration, and partly results from increased Ca2+ leak from sarcoplasmic reticulum stores via dysregulated ryanodine receptor (RyR) channels ...
Bers, Donald M +6 more
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Detection and characterization of protein interactions in vivo by a simple live-cell imaging method. [PDF]
PLoS ONE, 2013 Over the last decades there has been an explosion of new methodologies to study protein complexes. However, most of the approaches currently used are based on in vitro assays (e.g.
Oriol Gallego +5 more
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Scientific Reports, 2023 FK506 binding proteins (FKBPs) are a highly-conserved group of proteins known to bind to FK506, an immunosuppressive drug. They play different physiological roles, including transcription regulation, protein folding, signal transduction and ...
Neng Zhang +10 more
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Bright Molecular Strain Probe Templates for Reporting Protein–Protein Interactions
Sensors, 2023 Imaging protein–protein interactions (PPIs) is a hot topic in molecular medicine in the postgenomic sequencing era. In the present study, we report bright and highly sensitive single-chain molecular strain probe templates which embed full-length Renilla ...
Sung-Bae Kim +5 more
doaj +1 more source
Molecular Therapy: Nucleic Acids, 2022 Genetic lineage tracing is indispensable to unraveling the origin, fate, and plasticity of cells. However, the intrinsic leakiness in the CreER-loxP system raises concerns on data interpretation. Here, we reported the generation of a novel dual inducible
Mianqiao Chen +7 more
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