Results 91 to 100 of about 98,169 (229)

Absolute FKBP binding affinities obtained via nonequilibrium unbinding simulations [PDF]

The Journal of Chemical Physics, 2009
We compute the absolute binding affinities for two ligands bound to the FKBP protein using nonequilibrium unbinding simulations. The methodology is straightforward requiring little or no modification to many modern molecular simulation packages. The approach makes use of a physical pathway, eliminating the need for complicated alchemical decoupling ...
openaire   +3 more sources

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Engineered Elastin‐Like Polypeptides: Intelligent Self‐Assembling Platforms for Biomedical Application

Small Structures, Volume 7, Issue 3, March 2026.
Armed with unique structural and functional properties, elastin‐like polypeptides attract their attentions as programmable materials in biomedical applications, including fusion tags for protein and nucleic acid purification; nanocarriers for protein, chemotherapeutics, and imaging agent delivery; hydrogels for tissue regeneration, 3D model ...
Yang Yuan, Chen Zeng, Zichun Chen, Zhuoga Ciren, Qinran Yu, Chuanbo Wang, Hui Mao, Gang Li, Weizhi Chen, Xiqun Jiang   +9 more
wiley   +1 more source

HSP90 differentially stabilizes plant ABCB-type auxin transporters on the plasma membrane

Nature Communications
Closely related FKBP orthologs, FKBP42/TWISTED DWARF1 (TWD1) and FKBP38, have been shown to control the biogenesis of plant and mammalian ATP-binding cassette (ABC) transporters, respectively.
Tashi Tsering, Martin Di Donato, Despina Samakovli, Dimitra Milioni, Francesca Romana Iacobini, Konstantinos Panagiotopoulos, Panagiota-Konstantinia Plitsi, Elisa Azarello, Stefano Mancuso, Vendula Pukyšová, Marta Zwiewka, Tomasz Nodzynski, Michael Stumpe, Jutta Ludwig-Müller, Aurélien Bailly, Polydefkis Hatzopoulos, Markus M. Geisler   +16 more
doaj   +1 more source

Engineering FKBP-Based Destabilizing Domains to Build Sophisticated Protein Regulation Systems.

PLoS ONE, 2015
Targeting protein stability with small molecules has emerged as an effective tool to control protein abundance in a fast, scalable and reversible manner.
Wenlin An, Rachel E Jackson, Paul Hunter, Stefanie Gögel, Michiel van Diepen, Karen Liu, Martin P Meyer, Britta J Eickholt   +7 more
doaj   +1 more source

Plant Cyclophilins: Multifaceted Proteins With Versatile Roles

Frontiers in Plant Science, 2020
Cyclophilins constitute a family of ubiquitous proteins that bind cyclosporin A (CsA), an immunosuppressant drug. Several of these proteins possess peptidyl-prolyl cis-trans isomerase (PPIase) activity that catalyzes the cis-trans isomerization of the ...
Harpreet Singh, Harpreet Singh, Kirandeep Kaur, Mangaljeet Singh, Gundeep Kaur, Gundeep Kaur, Prabhjeet Singh   +6 more
doaj   +1 more source

IP3 receptor isoforms differently regulate ER-mitochondrial contacts and local calcium transfer [PDF]

, 2019
Contact sites of endoplasmic reticulum (ER) and mitochondria locally convey calcium signals between the IP3 receptors (IP3R) and the mitochondrial calcium uniporter, and are central to cell survival.
Alzayady, Kamil J., Ando, Hideaki, Bartok, Adam, Bánsághi, Száva, Csordás, György, Golenár, Tünde, Hajnóczky, György, Joseph, Suresh K., Katona, Máté, Mikoshiba, Katsuhiko, Nichtova, Zuzana, Thomas, V. Kaye, Weaver, David, Yule, David I.   +13 more
core   +1 more source

FKBP51 and FKBP52 in signaling and disease [PDF]

, 2011
FKBP51 and FKBP52 are diverse regulators of steroid hormone receptor signaling, including receptor maturation, hormone binding and nuclear translocation.
Cox, Marc B., Dickey, Chad A., Galigniana, Mario Daniel, Rein, Theo, Storer, Cheryl L.   +4 more
core   +2 more sources

Synthetic Cells on Demand: From Molecular Stimuli to Cellular Functions

ChemSystemsChem, Volume 8, Issue 2, March 2026.
ABSTRACT Synthetic cells constructed via bottom‐up approaches using lipid or polymer vesicles have become essential tools for mimicking cellular functions and studying synthetic biological systems. These vesicles can undergo morphological changes and trigger internal reactions in response to external stimuli, such as osmotic pressure, temperature, pH ...
Masato Suzuki, Koki Kamiya
wiley   +1 more source

Yeast Cls2p/Csg2p localized on the endoplasmic reticulum membrane regulates a non-exchangeable intracellular Ca2+ pool cooperatively with calcineurin [PDF]

, 1996
Saccharromyces cerevisiae CLS2 gene product (Cls2p) that is localized on the endoplasmic reticulum is important for the regulation of intracellular Ca2+ in a compartment distinct from the vacuole.
Tanida, Isei, Takita, Yoko, Hasegawa, Akira, Ohya, Yoshikazu, Anraku, Yasuhiro   +4 more
core   +1 more source