Results 21 to 30 of about 98,169 (229)
Distribution of Peptidyl-Prolyl Isomerase (PPIase) in the Archaea
Frontiers in Microbiology, 2021 Cis-trans isomerization of the peptide bond prior to proline is an intrinsically slow process but plays an essential role in protein folding. In vivo cis-trans isomerization reaction is catalyzed by Peptidyl-prolyl isomerase (PPIases), a category of ...
Anchal, Vineeta Kaushik, Manisha Goel
doaj +1 more source
Functional selectivity of GPCR-directed drug action through location bias. [PDF]
, 2017 G-protein-coupled receptors (GPCRs) are increasingly recognized to operate from intracellular membranes as well as the plasma membrane. The β 2 -adrenergic GPCR can activate G s -linked cyclic AMP (G s -cAMP) signaling from endosomes.
Conti, Marco +6 more
core +3 more sources
Spatial control of Draper receptor signaling initiates apoptotic cell engulfment. [PDF]
, 2017 The engulfment of apoptotic cells is essential for tissue homeostasis and recovering from damage. Engulfment is mediated by receptors that recognize ligands exposed on apoptotic cells such as phosphatidylserine (PS).
Adam P. Williamson +55 more
core +1 more source
Recent progress with FKBP-derived destabilizing domains [PDF]
Bioorganic & Medicinal Chemistry Letters, 2008 The FKBP-derived destabilizing domains are increasingly being used to confer small molecule-dependent stability to many different proteins. The L106P domain confers instability to yellow fluorescent protein when it is fused to the N-terminus, the C-terminus, or spliced into the middle of yellow fluorescent protein, however multiple copies of L106P do ...
Bernard W, Chu +3 more
openaire +2 more sources
Caffeine‐Operated Synthetic Modules for Chemogenetic Control of Protein Activities by Life Style
Advanced Science, 2021 A genetically encoded caffeine‐operated synthetic module (COSMO) is introduced herein as a robust chemically induced dimerization (CID) system. COSMO enables chemogenetic manipulation of biological processes by caffeine and its metabolites, as well as ...
Tianlu Wang +8 more
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JCI Insight, 2023 We examine whether calcineurin or protein phosphatase 2B (PP2B) regulates the basolateral inwardly rectifying potassium channel Kir4.1/Kir5.1 in the distal convoluted tubule (DCT). Application of tacrolimus (FK506) or cyclosporine A (CsA) increased whole-
Dan-Dan Zhang +7 more
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Structural insights into Plasmodium PPIases
Frontiers in Cellular and Infection Microbiology, 2022 Malaria is one of the most prevalent infectious diseases posing a serious challenge over the years, mainly owing to the emergence of drug-resistant strains, sparking a need to explore and identify novel protein targets.
Sreekanth Rajan +3 more
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FKBP51 and FKBP12.6-Novel and tight interactors of Glomulin.
PLoS ONE, 2019 The protein factor Glomulin (Glmn) is a regulator of the SCF (Skp1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. Mutations of Glmn lead to glomuvenous malformations.
Andreas Hähle +6 more
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FKBP12 is a major regulator of ALK2 activity in multiple myeloma cells
Cell Communication and Signaling, 2023 Background The immunophilin FKBP12 binds to TGF-β family type I receptors, including the BMP type I receptor ALK2. FKBP12 keeps the type I receptor in an inactive state and controls signaling activity. Removal of FKBP12 with drugs such as the FKBP-ligand
Ingrid Quist-Løkken +10 more
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Update on the Neisseria Macrophage Infectivity Potentiator-Like PPIase Protein
Frontiers in Cellular and Infection Microbiology, 2022 Neisseria pathogens express a Macrophage Infectivity Potentiator Protein (MIP), which belongs to the FK506 binding protein (FKBP) family of proteins that exhibit peptidyl-prolyl cis/trans isomerase (PPIase) activity.
Myron Christodoulides
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