Results 31 to 40 of about 98,169 (229)
BMC Genomics, 2018 Background The FK506-binding proteins (FKBPs) play diverse roles in numerous critical processes for plant growth, development, and abiotic stress responses.
Qinglong Dong +10 more
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RIPK3 restricts viral pathogenesis via cell death-independent neuroinflammation [PDF]
, 2017 Receptor-interacting protein kinase-3 (RIPK3) is an activator of necroptotic cell death, but recent work has implicated additional roles for RIPK3 in inflammatory signaling independent of cell death.
Daniels, Brian P. +9 more
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Solution structure of FK506 bound to FKBP‐12 [PDF]
FEBS Letters, 1992 The complex of the immunosuppressant FK506 bound to FKBP‐12 has been studied in solution using 1H and inverse‐detected 13C NMR methods. The resonances of bound, 13C‐labelled FK506 were assigned and a set of 66 intraligand NOE distance restraints were used to calculate the structure of the bound ligand by distance geometry and restrained molecular ...
Lepre, Christopher A. +2 more
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Engineering a Rapid Insulin Release System Controlled By Oral Drug Administration
Advanced Science, 2022 Rapid insulin release plays an essential role in maintaining blood‐glucose homeostasis in mammalians. Patients diagnosed with type‐I diabetes mellitus experience chronic and remarkably high blood‐sugar levels, and require lifelong insulin injection ...
Mohamed Mahameed +4 more
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Frontiers in Plant Science, 2022 Potato is the most important non-grain food in the world, while late blight caused by Phytophthora infestans seriously threatens the production of potato.
Yang Mu +27 more
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Altered chemomechanical coupling causes impaired motility of the kinesin-4 motors KIF27 and KIF7. [PDF]
, 2018 Kinesin-4 motors play important roles in cell division, microtubule organization, and signaling. Understanding how motors perform their functions requires an understanding of their mechanochemical and motility properties.
Blasius, T Lynne +7 more
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Regulation von ABC-Transportern durch FKBPs [PDF]
BIOspektrum, 2021 AbstractThe plant hormone auxin is distributed in the plant by a sophisticated network of importers and exporters, including members of the ABCB subclass of ATP-binding cassette (ABC) transporters. ABCB-mediated auxin transport is controlled by Twisted Dwarf1, a member of the FK506-binding protein (FKBP) family.
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Anterograde Transport of Rab4-Associated Vesicles Regulates Synapse Organization in Drosophila
Cell Reports, 2017 Local endosomal recycling at synapses is essential to maintain neurotransmission. Rab4GTPase, found on sorting endosomes, is proposed to balance the flow of vesicles among endocytic, recycling, and degradative pathways in the presynaptic compartment ...
Swagata Dey, Gary Banker, Krishanu Ray
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Coordinated oscillations in cortical actin and Ca2+ correlate with cycles of vesicle secretion. [PDF]
, 2012 The actin cortex both facilitates and hinders the exocytosis of secretory granules. How cells consolidate these two opposing roles was not well understood. Here we show that antigen activation of mast cells induces oscillations in Ca(2+) and PtdIns(4,5)P(
Meyer, T, Wollman, R
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FKBP Family Proteins: Immunophilins with Versatile Biological Functions [PDF]
Neurosignals, 2008 Immunophilins consist of a family of highly conserved proteins binding with immunosuppressive drugs such as FK506, rapamycin and cyclosporin A. FK506-binding protein (FKBP) is one of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity.
Kang, Cong Bao +3 more
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