Results 41 to 50 of about 98,169 (229)

Novel cycloheximide derivatives targeting the moonlighting protein Mip exhibit specific antimicrobial activity against Legionella pneumophila

Frontiers in Bioengineering and Biotechnology, 2015
Mip (macrophage infectivity potentiator) and Mip-like proteins are virulence factors in a wide range of pathogens including Legionella pneumophila. These proteins belong to the FK506 binding protein (FKBP) family of peptidyl-prolyl-cis/trans-isomerases ...
Janine eRasch, Martin eTheuerkorn, Can eÜnal, Can eÜnal, Natascha eHeinsohn, Stefan eTran, Gunter eFischer, Gunter eFischer, Matthias eWeiwad, Matthias eWeiwad, Michael eSteinert, Michael eSteinert   +11 more
doaj   +1 more source

Cyclophilin-A is bound to through its peptidylprolyl isomerase domain to the cytoplasmic dynein motor protein complex [PDF]

, 2004
Although cyclophilin A (CyP-A) is a relatively abundant small immunophilin present in the cytoplasm of all mammalian cells, its general function(s) in the absence of the immunosuppressant drug cyclosporin A is not known.
Galigniana, Mario Daniel, Gallay, Philippe A., Morishima, Yoshihiro, Pratt, William B.   +3 more
core   +2 more sources

Genome-Wide Identification of the FKBP Gene Family in Rice and Its Potential Roles in Blast Resistance

Agronomy
Rice (Oryza sativa L.) is a major global staple crop, yet its productivity is severely constrained by rice blast disease caused by Magnaporthe oryzae.
Jiazong Liu, Xin Wang, Wendi Li, Qiyue Xu, Xinhua Ding, Ziyi Yin   +5 more
doaj   +1 more source

Systematic analysis of FKBP inducible degradation domain tagging strategies for the human malaria parasite Plasmodium falciparum. [PDF]

PLoS ONE, 2012
Targeted regulation of protein levels is an important tool to gain insights into the role of proteins essential to cell function and development. In recent years, a method based on mutated forms of the human FKBP12 has been established and used to great ...
Mauro Ferreira de Azevedo, Paul R Gilson, Heloisa B Gabriel, Roseli F Simões, Fiona Angrisano, Jacob Baum, Brendan S Crabb, Gerhard Wunderlich   +7 more
doaj   +1 more source

Mutations in Hsp90 Cochaperones Result in a Wide Variety of Human Disorders

Frontiers in Molecular Biosciences, 2021
The Hsp90 molecular chaperone, along with a set of approximately 50 cochaperones, mediates the folding and activation of hundreds of cellular proteins in an ATP-dependent cycle.
Jill L. Johnson
doaj   +1 more source

αSynuclein control of mitochondrial homeostasis in human-derived neurons is disrupted by mutations associated with Parkinson’s disease [PDF]

, 2017
The etiology of Parkinson’s disease (PD) converges on a common pathogenic pathway of mitochondrial defects in which α-Synuclein (αSyn) is thought to play a role.
Alloatti, Matías, Cromberg, Lucas Eneas, Dimopoulos, Nicolás, Falzone, Tomas Luis, Marin Burgin, Antonia, Otero, Maria Gabriela, Pardi, María Belén, Pozo Devoto, Victorio Martin, Saez, Trinidad María de Los Milagros, Scassa, Maria Elida, Schinder, Alejandro Fabián, Sevlever, Gustavo, Stokin, Gorazd B.   +12 more
core   +1 more source

The novel missense mutation Met48Lys in FKBP22 changes its structure and functions. [PDF]

, 2020
Mutations in the FKBP14 gene encoding FKBP22 (FK506 Binding Protein 22 kDa) cause kyphoscoliotic Ehlers-Danlos Syndrome (kEDS). The first clinical report showed that a lack of FKBP22 protein due to mutations causing nonsense-mediated decay of the mRNA ...
Bächinger, Hans Peter, Giunta, Cecilia, Gould, Douglas B, Holden, Paul, Ishikawa, Yoshihiro, Lim, Pei Jin, Mizuno, Nobuyo, Rohrbach, Marianne   +7 more
core  

Hepatic regeneration and growth factors [PDF]

, 1993
Nessun ...
Azzarone, A, Barone, M, Francavilla, A, Polimeno, L, Starzl, TE   +4 more
core   +1 more source

Peptidylprolyl Isomerases as In Vivo Carriers for Drugs That Target Various Intracellular Entities

Biomolecules, 2017
Analyses of sequences and structures of the cyclosporine A (CsA)-binding proteins (cyclophilins) and the immunosuppressive macrolide FK506-binding proteins (FKBPs) have revealed that they exhibit peculiar spatial distributions of charges, their overall ...
Andrzej Galat
doaj   +1 more source

Multi-Omics Analysis of the Expression and Prognosis for FKBP Gene Family in Renal Cancer

Frontiers in Oncology, 2021
BackgroundThe FK506-binding protein (FKBP) is a family of intracellular receptors that can bind specifically to the immunosuppressant FK506 and rapamycin.
Zeqiang Sun, Xin Qin, Juanjuan Fang, Yueqing Tang, Yidong Fan   +4 more
doaj   +1 more source