Results 91 to 100 of about 61,644 (304)

Structure and Intermolecular Interactions between L-Type Straight Flagellar Filaments. [PDF]

, 2017
Bacterial mobility is powered by rotation of helical flagellar filaments driven by rotary motors. Flagellin isolated from the Salmonella Typhimurium SJW1660 strain, which differs by a point mutation from the wild-type strain, assembles into straight ...
Dogic, Zvonimir, Dvir, Tom, Ginsburg, Avi, Louzon, Daniel, Raviv, Uri, Schwenger, Walter   +5 more
core  

Caspase-1 engagement and TLR-induced c-FLIP expression suppress ASC/caspase-8-dependent apoptosis by inflammasome sensors NLRP1b and NLRC4 [PDF]

, 2017
The caspase activation and recruitment domain (CARD)-based inflammasome sensors NLRP1b and NLRC4 induce caspase-1-dependent pyroptosis independent of the inflammasome adaptor ASC.
D'Hont, Jinke, Demon, Dieter, Gonçalves, Amanda, Hochepied, Tino, Kanneganti, Thirumala-Devi, Krautwald, Stefan, Lamkanfi, Mohamed, Matusiak, Magdalena, Moraes de Vasconcelos, Nathalia, Van Gorp, Hanne, Van Hauwermeiren, Filip, Van Opdenbosch, Nina, Vande Walle, Lieselotte, Verdonckt, Maarten, Viana Saavedra, Pedro Henrique   +14 more
core   +2 more sources

Role of Flagellin-Homologous Proteins in Biofilm Formation by Pathogenic Vibrio Species

mBio, 2019
Flagellar filaments of the pathogenic Vibrio species, including V. vulnificus, V. parahaemolyticus, and V. cholerae, are composed of multiple flagellin subunits.
You-Chul Jung, Mi‐Ae Lee, Kyu-Ho Lee
semanticscholar   +1 more source

The Impact of Toll‐Like Receptor 5 on Liver Function in Age‐Related Metabolic Disorders

Aging Cell, EarlyView.
Toll‐like receptor 5 (TLR5) deficiency accelerates age‐related metabolic disorders, leading to obesity, fatty liver, and cellular changes such as lipid accumulation in PMHs (hepatocytes) and activation of HSCs (hepatic stellate cells), which drive fibrosis.
Dong‐Hyun Kim, Hye Sun Go, Eun Jae Jeon, Thi Quynh Trang Nguyen, Da Yeon Kim, Hansung Park, Hyo‐Ji Eom, Sung Young Kim, Sang Chul Park, Kyung A Cho   +9 more
wiley   +1 more source

Conformational adaptability of the terminal regions of flagellin

Biophysical Journal, 1992
Secondary structure formation in the disordered terminal regions of flagellin were studied by circular dichroic (CD) spectroscopy, Fourier transform infrared spectroscopy, and x-ray diffraction. The terminal regions of flagellin are known to form alpha-helical bundles upon polymerization into flagellar filaments. We found from comparative CD studies of
Ferenc Vonderviszt, M. Tasumi, Masashi Sonoyama, Keiichi Namba   +3 more
openaire   +3 more sources

A conserved TLR5 binding and activation hot spot on flagellin

Scientific Reports, 2017
Flagellin is a bacterial protein that polymerizes into the flagellar filament and is essential for bacterial motility. When flagellated bacteria invade the host, flagellin is recognized by Toll-like receptor 5 (TLR5) as a pathogen invasion signal and ...
W. Song, Y. Jeon, B. Namgung, M. Hong, Sung-il Yoon   +4 more
semanticscholar   +1 more source

A Salmonella virulence factor activates the NOD1/NOD2 signaling pathway. [PDF]

, 2011
The invasion-associated type III secretion system (T3SS-1) of Salmonella enterica serotype Typhimurium (S. Typhimurium) activates the transcription factor NF-κB in tissue culture cells and induces inflammatory responses in animal models through unknown ...
Bäumler, Andreas J, Keestra, A Marijke, Kim, Anita, Klein-Douwel, Daisy, Tsolis, Renée M, Winter, Maria G, Winter, Sebastian E, Xavier, Mariana N   +7 more
core   +2 more sources

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source

Advantages and Limitations of Integrated Flagellin Adjuvants for HIV-Based Nanoparticle B-Cell Vaccines

Pharmaceutics, 2019
The great advantage of virus-like particle (VLP) nano-vaccines is their structural identity to wild-type viruses, ensuring that antigen-specific B-cells encounter viral proteins in their natural conformation.
Cornelia Barnowski, Nicole Kadzioch, Dominik Damm, Huimin Yan, Vladimir Temchura   +4 more
doaj   +1 more source

Binding of Campylobacter jejuni FliW Adjacent to the CsrA RNA-Binding Pockets Modulates CsrA Regulatory Activity

Frontiers in Microbiology, 2021
Campylobacter jejuni CsrA is an mRNA-binding, post-transcriptional regulator that controls many metabolic- and virulence-related characteristics of this important pathogen. In contrast to E.
Marek Bogacz, Faiha M. El Abbar, Claudia A. Cox, Jiaqi Li, Jarred S. Fiedler, Lynn K. H. Tran, Paul M. H. Tran, C. Luke Daugherty, Kate H. Blake, Zhirui Wang, Parastoo Azadi, Stuart A. Thompson   +11 more
doaj   +1 more source