Results 11 to 20 of about 55,682 (249)
Flagellin as a vaccine adjuvant
Expert Review of Vaccines, 2018 Introduction: Bacterial flagellin, as a pathogen-associated molecular pattern (PAMP), can activate both innate and adaptive immunity. Its unique structural characteristics endow an effective and flexible adjuvant activity, which allow the design of ...
Xinsheng Liu +2 more
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FliS/flagellin/FliW heterotrimer couples type III secretion and flagellin homeostasis [PDF]
Scientific Reports, 2018 Flagellin is amongst the most abundant proteins in flagellated bacterial species and constitutes the major building block of the flagellar filament. The proteins FliW and FliS serve in the post-transcriptional control of flagellin and guide the protein ...
Florian Altegoer +6 more
doaj +4 more sources
Flagellin co-expression potentiates mRNA vaccine-induced cytotoxic T lymphocyte responses but not anti-tumor immunity [PDF]
Scientific ReportsPersonalized neoantigen mRNA vaccine showed high potency to treat advanced melanoma and pancreatic cancer in recent clinical trials. Strategies to further increase its therapeutic efficacy are highly demanded.
Yibo Li +6 more
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Pseudomonas Evades Immune Recognition of Flagellin in Both Mammals and Plants
PLoS Pathogens, 2011 The building blocks of bacterial flagella, flagellin monomers, are potent stimulators of host innate immune systems. Recognition of flagellin monomers occurs by flagellin-specific pattern-recognition receptors, such as Toll-like receptor 5 (TLR5) in ...
Bart W Bardoel +2 more
exaly +3 more sources
Sci, 2021 Toll-like receptor 5 ligand, flagellin, and vascular adhesion protein 1 (VAP-1) are involved in non-alcoholic fatty liver disease. This study aimed to determine whether VAP-1 mediates flagellin-induced hepatic fat accumulation.
Raine Toivonen +9 more
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Luminal-applied flagellin is internalized by polarized intestinal epithelial cells and elicits immune responses via the TLR5 dependent mechanism. [PDF]
PLoS ONE, 2011 Bacteria release flagellin that elicits innate responses via Toll-like receptor 5 (TLR5). Here, we investigated the fate of apically administrated full length flagellin from virulent and avirulent bacteria, along with truncated recombinant flagellin ...
Tonyia Eaves-Pyles +6 more
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Journal of Bacteriology, 1977 Flagellins from 17 Caulobacter strains were partially purified. Their molecular weights and immunological properties indicated that a two-component flagellin system is common among Caulobacters.
C, Lagenaur, N, Agabian
openaire +2 more sources
Intraluminal Flagellin Differentially Contributes to Gut Dysbiosis and Systemic Inflammation following Burn Injury. [PDF]
PLoS ONE, 2016 Burn injury is associated with a loss of gut barrier function, resulting in systemic dissemination of gut-derived bacteria and their products. The bacterial protein and TLR5 agonist, flagellin, induces non-specific innate immune responses.
Logan Grimes +7 more
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Cell Reports, 2023 Summary: Unidirectional growth of filamentous protein assemblies including the bacterial flagellum relies on dedicated polymerization factors (PFs). The molecular determinants and structural transitions imposed by PFs on multi-subunit assembly are poorly
Nicolas Kint, Patrick H. Viollier
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mTORC1 Regulates Flagellin-Induced Inflammatory Response in Macrophages. [PDF]
PLoS ONE, 2015 Bacterial flagellin triggers inflammatory responses. Phosphoinositide 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) regulate the production of pro- and anti-inflammatory cytokines that are induced by extrinsic antigens, but the function of ...
Wenlei Bao +8 more
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