Results 31 to 40 of about 30,529 (162)

Flagellin/TLR5 Stimulate Myeloid Progenitors to Enter Lung Tissue and to Locally Differentiate Into Macrophages

Frontiers in Immunology, 2021
Toll-like receptor 5 (TLR5) is the receptor of bacterial Flagellin. Reportedly, TLR5 engagement helps to combat infections, especially at mucosal sites, by evoking responses from epithelial cells and immune cells. Here we report that TLR5 is expressed on
Xin Lei, Xin Lei, Jara Palomero, Iris de Rink, Tom de Wit, Tom de Wit, Martijn van Baalen, Yanling Xiao, Yanling Xiao, Jannie Borst, Jannie Borst   +10 more
doaj   +1 more source

Flagellin attenuates experimental sepsis in a macrophage-dependent manner

Critical Care, 2019
Background Sepsis is the leading cause of death among critically ill patients, and no specific therapeutic agent is currently approved for the treatment of sepsis. Methods We assessed the effects of flagellin administration on survival, bacterial burden,
Xiaoliang Yang, Yibing Yin, Xingxing Yan, Zebo Yu, Yi Liu, Ju Cao   +5 more
doaj   +1 more source

An immune receptor complex evolved in soybean to perceive a polymorphic bacterial flagellin

Nature Communications, 2020
Ralstonia solanacearum evades plant immunity by producing an atypical flagellin protein, thus causing bacterial wilt disease. Here, Wei et al. show that soybean has evolved a divergent flagellin receptor that recognises R.
Yali Wei, Alexandra Balaceanu, Jose S. Rufian, Cécile Segonzac, Achen Zhao, Rafael J. L. Morcillo, Alberto P. Macho   +6 more
doaj   +1 more source

MAP1S controls breast cancer cell TLR5 signaling pathway and promotes TLR5 signaling-based tumor suppression. [PDF]

PLoS ONE, 2014
Targeting TLR5 signaling in breast cancer represents a novel strategy in cancer immunotherapy. However, the underlying mechanism by which TLR5 signaling inhibits cancer cell proliferation and tumor growth has not been elucidated.
Ming Shi, Yuanfei Yao, Fang Han, Yiqun Li, Yu Li   +4 more
doaj   +1 more source

Halobacterial flagellins are sulfated glycoproteins.

Journal of Biological Chemistry, 1985
The cell-surface glycoprotein of Halobacteria contains oligosaccharides of the type Glc4----1GlcA4----1GlcA4----1GlcA (where GlcA indicates glucuronic acid) with a sulfate group attached to each of the GlcA residues. We report here that in addition to this cell-surface glycoprotein, the halobacterial flagellar proteins (recently described by Alam, M ...
Wieland, F., Pauli, G., Sumper, Manfred
openaire   +3 more sources

Mucosal immunization with a flagellin-adjuvanted Hgp44 vaccine enhances protective immune responses in a murine Porphyromonas gingivalis infection model

Human Vaccines & Immunotherapeutics, 2017
Chronic periodontitis is caused by interactions between the oral polymicrobial community and host factors. Periodontal diseases are associated with dysbiotic shift in oral microbiota.
Sao Puth, Seol Hee Hong, Mi Jin Park, Hye Hwa Lee, Youn Suhk Lee, Kwangjoon Jeong, In-Chol Kang, Jeong Tae Koh, Byounggon Moon, Sang Chul Park, Joon Haeng Rhee, Shee Eun Lee   +11 more
doaj   +1 more source

Flagellin from an Incompatible Strain of Acidovorax avenae Mediates H2O2 Generation Accompanying Hypersensitive Cell Death and Expression of PAL, Cht-1, and PBZ1, but Not of LOX in Rice

Molecular Plant-Microbe Interactions, 2003
Acidovorax avenae causes a brown stripe disease in monocot plants. We recently reported that a rice-incompatible strain of A. avenae caused hypersensitive cell death in rice and that the flagellin of the incompatible strain was involved in this response.
Noriko Tanaka, Fang-Sik Che, Naohide Watanabe, Satsuki Fujiwara, Seiji Takayama, Akira Isogai   +5 more
doaj   +1 more source

Stenotrophomonas maltophilia provokes NEU1-mediated release of a flagellin-binding decoy receptor that protects against lethal infection

iScience
Summary: Stenotrophomonas maltophilia (Sm), a multidrug-resistant pathogen often isolated from immunocompromised individuals, presents its flagellin to multimeric tandem repeats within the ectodomain of mucin-1 (MUC1-ED), expressed on airway epithelia ...
Erik P. Lillehoj, Yafan Yu, Avelino C. Verceles, Akihiro Imamura, Hideharu Ishida, Kurt H. Piepenbrink, Simeon E. Goldblum   +6 more
doaj   +1 more source

Shoc2 recognizes bacterial flagellin and mediates antibacterial Erk/Stat signaling in an invertebrate.

PLoS Pathogens, 2022
Flagellin is a key bacterial virulence factor that can stimulate molecular immune signaling in both animals and plants. The detailed mechanisms of recognizing flagellin and mounting an efficient immune response have been uncovered in vertebrates; however,
Bao-Rui Zhao, Xin-Xin Wang, Xian-Wei Wang   +2 more
doaj   +1 more source

Flagellin-induced corneal antimicrobial peptide production and wound repair involve a novel NF-kappaB-independent and EGFR-dependent pathway.

PLoS ONE, 2010
BackgroundThe bacterial protein flagellin plays a major role in stimulating mucosal surface innate immune response to bacterial infection and uniquely induces profound cytoprotection against pathogens, chemicals, and radiation.
Nan Gao, Ashok Kumar, Jeevan Jyot, Fu-Shin Yu   +3 more
doaj   +1 more source