Results 51 to 60 of about 30,529 (162)

Analysis of Flagellin-Specific Adaptive Immunity Reveals Links to Dysbiosis in Patients With Inflammatory Bowel DiseaseSummary

Cellular and Molecular Gastroenterology and Hepatology, 2020
Background & Aims: Bacterial flagellin is an important antigen in inflammatory bowel disease, but the role of flagellin-specific CD4+ T cells in disease pathogenesis remains unclear.
Laura Cook, Daniel J. Lisko, May Q. Wong, Rosa V. Garcia, Megan E. Himmel, Ernest G. Seidman, Brian Bressler, Megan K. Levings, Theodore S. Steiner   +8 more
doaj   +1 more source

TLR5 signaling in murine bone marrow induces hematopoietic progenitor cell proliferation and aids survival from radiation

Blood Advances, 2017
: Administration of the bacterial protein flagellin to mice activates innate immune signaling that protects against an array of challenges, including ionizing radiation. Herein, we define the underlying mechanism for this protection.
Benyue Zhang, Damilola Oyewole-Said, Jun Zou, Ifor R. Willliams, Andrew T. Gewirtz   +4 more
doaj   +1 more source

Rice cDNA Microarray-Based Gene Expression Profiling of the Response to Flagellin Perception in Cultured Rice Cells

Molecular Plant-Microbe Interactions, 2004
Incompatible strains of Acidovorax avenae elicit an immune response in cultured rice cells, with immunity specifically induced by the flagellin of the incompatible strain.
Satsuki Fujiwara, Noriko Tanaka, Takashi Kaneda, Seiji Takayama, Akira Isogai, Fang-Sik Che   +5 more
doaj   +1 more source

Flagellin Restricts HIV-1 Infection of Macrophages through Modulation of Viral Entry Receptors and CC Chemokines

Viruses
Both bacteria product flagellin and macrophages are implicated in HIV-1 infection/disease progression. However, the impact of their interaction on HIV-1 infection and the associated mechanisms remain to be determined.
Lina Zhou, Xu Wang, Qianhao Xiao, Shazheb Khan, Wen-Zhe Ho   +4 more
doaj   +1 more source

Flagellin acting via TLR5 is the major activator of key signaling pathways leading to NF-κB and proinflammatory gene program activation in intestinal epithelial cells

BMC Microbiology, 2004
Background Infection of intestinal epithelial cells by pathogenic Salmonella leads to activation of signaling cascades that ultimately initiate the proinflammatory gene program.
Lupica Joseph, Kar Niladri, Deb Amitabha, Tallant Thomas, de Veer Michael J, DiDonato Joseph A   +5 more
doaj   +1 more source

Immunization with Bivalent Flagellin Protects Mice against Fatal Pseudomonas aeruginosa Pneumonia

Journal of Immunology Research, 2017
Pseudomonas aeruginosa lung infections present a major challenge to healthcare systems worldwide because they are commonly associated with high morbidity and mortality.
Bahador Behrouz, Farhad B. Hashemi, Mohammad Javad Fatemi, Sara Naghavi, Gholamreza Irajian, Raheleh Halabian, Abbas Ali Imani Fooladi   +6 more
doaj   +1 more source

Harnessing the acceptor substrate promiscuity of Clostridium botulinum Maf glycosyltransferase to glyco-engineer mini-flagellin protein chimeras

Communications Biology
Several bacterial flagellins are O-glycosylated with nonulosonic acids on surface-exposed Serine/Threonine residues by Maf glycosyltransferases. The Clostridium botulinum Maf glycosyltransferase (CbMaf) displays considerable donor substrate promiscuity ...
Sonali Sunsunwal, Aasawari Khairnar, Srikrishna Subramanian, T.N.C. Ramya   +3 more
doaj   +1 more source

Flagellin unmasked [PDF]

Nature Plants, 2019
openaire   +2 more sources

TLR5 activation in respiratory epithelial cells orchestrate mucosal Th17 response through both indirect and direct pathways

Respiratory Research
Background Flagellin, a potent mucosal adjuvant administered via the intranasal route, has been widely recognized for its capacity to enhance immune responses against diverse pathogens.
Sijian Huang, Xu Li, Yuan Cao, Man Mou, Jianlun Li, Kexing Zhuo, Lijuan Wang, Zihang Zeng, Xianghong Wei, Chunlian Tang, Maohua Zhong   +10 more
doaj   +1 more source

The structure of the Vibrio alginolyticus flagellar filament suggests molecular mechanism for the rotation of sheathed flagella. [PDF]

Nat Commun
Qin K, Einenkel R, Zhao W, Kühne C, Atherton J, Erhardt M, Bergeron JRC.   +6 more
europepmc   +2 more sources