Results 81 to 90 of about 4,596,229 (314)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity
FEBS Open Bio, EarlyView.Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz +9 more
wiley +1 more source
Analysis of the response surface method for optimising the flatness of ceramic-metal brazing
Hanjie xuebaoCeramic-to-metal packaging is widely used as a key process in electronic vacuum devices in integrated circuit packaging, medical devices, and defence.The flatness of the two connections determines the reliability of the chip, and it is of great ...
Guanghui WANG +4 more
doaj +1 more source
Mathematics, 2020 This article proposes a new control law for an embedded DC distributed network supplied by a supercapacitor module (as a supplementary source) and a battery module (as the main generator) for transportation applications.
Burin Yodwong +3 more
doaj +1 more source
Identification of machining defects by Small Displacement Torsor and form parameterization method [PDF]
, 2010 In the context of product quality, the methods that can be used to estimate machining defects and predict causes of these defects are one of the important factors of a manufacturing process.
Bui, Minh-Hien +5 more
core +2 more sources
Raman‐based label‐free microscopic analysis of the pancreas in living zebrafish larvae
FEBS Open Bio, EarlyView.Forward stimulated Raman scattering (F‐SRS) and epi coherent anti‐Stokes Raman scattering (E‐CARS) allow label‐free discrimination of distinct subcellular structures in the pancreas of living zebrafish larvae. Given the straightforward applicability, we anticipate broad implementation of Raman microscopy in other organs and across various biomedical ...
Noura Faraj +3 more
wiley +1 more source
Disturbance-Resilient Flatness-Based Control for End-Effector Rehabilitation Robotics
ActuatorsRobotic-assisted therapy is an increasingly vital approach for upper-limb rehabilitation, offering consistent, high-intensity training critical to neuroplastic recovery.
Soraya Bououden +4 more
doaj +1 more source
Flatness-based pre-compensation of laser diodes
, 2008 International audienceA physical nonlinear dynamical model of a laser diode is considered. We propose a feed-forward control scheme based on differential flatness for the design of input-current modulations to compensate diode distortions. The goal is to
Abichou, A. +2 more
core +2 more sources
FEBS Open Bio, EarlyView.Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu +5 more
wiley +1 more source
Trajectory Tracking Control for a Boost Converter Based on the Differential Flatness Property
IEEE Access, 2019 This paper presents the control design for the regulation and trajectory tracking tasks of the non-minimum phase output voltage of a DC-DC Boost-type power converter. The proposed approach exploits the differential flatness property of the system leading
Leopoldo Gil-Antonio +4 more
doaj +1 more source