Results 41 to 50 of about 71,504 (306)

Characterization of the Ornithine Hydroxylation Step in Albachelin Biosynthesis

Molecules, 2017
N-Hydroxylating monooxygenases (NMOs) are involved in siderophore biosynthesis. Siderophores are high affinity iron chelators composed of catechol and hydroxamate functional groups that are synthesized and secreted by microorganisms and plants. Recently,
Kendra Bufkin, Pablo Sobrado
doaj   +1 more source

N′¹,N′⁴-bis(2-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethylidene)succinohydrazide

Molbank, 2022
The title compound, N′1,N′4-bis(2-(7,8-dimethyl-2,4-dioxo-3,4-dihydrobenzo[g]pteridin-10(2H)-yl)ethylidene)succinohydrazide (1), was obtained by the reaction of formylmethylflavin and succinic acid dihydrazide.
Taishu Kawada, Katsuhito Kino, Yoshihiko Matsuzawa, Masayuki Morikawa, Yasuko Okamoto, Takanobu Kobayashi, Yoshiyuki Tanaka   +6 more
doaj   +1 more source

Flavin-Dependent Thymidylate Synthase as a New Antibiotic Target

Molecules, 2016
In humans de novo synthesis of 2′-deoxythymidine-5′-monophosphate (dTMP), an essential building block of DNA, utilizes an enzymatic pathway requiring thymidylate synthase (TSase) and dihydrofolate reductase (DHFR). The enzyme flavin-dependent thymidylate
Michael Choi, Kalani Karunaratne, Amnon Kohen   +2 more
doaj   +1 more source

Monooxygenation of aromatic compounds by flavin‐dependent monooxygenases

Protein Science, 2018
Many flavoenzymes catalyze hydroxylation of aromatic compounds especially phenolic compounds have been isolated and characterized. These enzymes can be classified as either single‐component or two‐component flavin‐dependent hydroxylases (monooxygenases).
Pirom Chenprakhon, Thanyaporn Wongnate, P. Chaiyen   +2 more
semanticscholar   +1 more source

QM/MM Modeling of the Flavin Functionalization in the RutA Monooxygenase

Molecules, 2023
Oxygenase activity of the flavin-dependent enzyme RutA is commonly associated with the formation of flavin-oxygen adducts in the enzyme active site. We report the results of quantum mechanics/molecular mechanics (QM/MM) modeling of possible reaction ...
Bella Grigorenko, Tatiana Domratcheva, Alexander Nemukhin   +2 more
doaj   +1 more source

A Cysteine Pair Controls Flavin Reduction by Extracellular Cytochromes during Anoxic/Oxic Environmental Transitions

mBio, 2023
Many bacteria of the genus Shewanella are facultative anaerobes able to reduce a broad range of soluble and insoluble substrates, including Fe(III) mineral oxides.
Michael P. Norman, Marcus J. Edwards, Gaye F. White, Joshua A. J. Burton, Julea N. Butt, David J. Richardson, Ricardo O. Louro, Catarina M. Paquete, Thomas A. Clarke   +8 more
doaj   +1 more source

Auxin biosynthesis by the YUCCA flavin monooxygenases controls the formation of floral organs and vascular tissues in Arabidopsis.

Genes & Development, 2006
Auxin biosynthesis in plants has remained obscure although auxin has been known for decades as a key regulator for plant growth and development.
Youfa Cheng, Xinhua Dai, Yunde Zhao
semanticscholar   +1 more source

A flavin-dependent halogenase from metagenomic analysis prefers bromination over chlorination

PLoS ONE, 2018
Flavin-dependent halogenases catalyse halogenation of aromatic compounds. In most cases, this reaction proceeds with high regioselectivity and requires only the presence of FADH2, oxygen, and halide salts.
P. R. Neubauer, C. Widmann, D. Wibberg, L. Schröder, M. Frese, T. Kottke, J. Kalinowski, H. Niemann, N. Sewald   +8 more
semanticscholar   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

A Click Chemistry Approach towards Flavin-Cyclodextrin Conjugates—Bioinspired Sulfoxidation Catalysts

Molecules, 2015
A click chemistry approach based on the reaction between alkynylflavins and mono(6-azido-6-deoxy)-β-cyclodextrin has proven to be a useful tool for the synthesis of flavin-cyclodextrin conjugates studied as monooxygenase mimics in enantioselective ...
Petra Tomanová, Jiří Šturala, Miloš Buděšínský, Radek Cibulka   +3 more
doaj   +1 more source