Results 61 to 70 of about 59,356 (219)
Advanced Therapeutics, EarlyView.This review explores how antibody engineering and display technologies are driving therapeutic advances against mosquito‐borne orthoflaviviruses such as Zika, dengue, and yellow fever viruses. It highlights diverse neutralizing targets on the envelope protein, including the conserved fusion loop, and discusses how Fc engineering, rational antigen ...
Ana Clara Barbosa Antonelli +5 more
wiley +1 more source
Development of Double Antibody Sandwich ELISA for Detection of Duck or Goose Flavivirus
Journal of Integrative Agriculture, 2013 In order to establish double antibody sandwich enzyme-linked immunosorbent assay (DAS-ELISA) for detection of duck or goose flavivirus, polyclonal antibody against the flavivirus strain JS804 in geese and monoclonal antibody against the E protein of ...
Hui-min NIU +10 more
doaj +1 more source
Animals, 2020 Background: A retrospective sero-survey for evidence of West Nile virus (WNV) infection in European wild boar (Sus scorfa) was conducted in the Latium region, Italy, on stored serum samples of the period November 2011 to January 2012.
Angela Petruccelli +6 more
doaj +1 more source
Insects, 2021 Arthropod-borne viruses belonging to the flavivirus genus possess an enormous relevance in public health. Neotropical non-human primates (NPs) have been proposed to be susceptible to flavivirus infections due to their arboreal and diurnal habits, their ...
Andrea Chaves +6 more
doaj +1 more source
Advanced Science, EarlyView.A simple and general photoactivatable approach is developed to regulate DNA polymerase activity, enabling light‐start isothermal amplification on demand. The molecular dynamics simulations reveals that the photocaged primer blocks DNA polymerase activity by inhibiting the conformational change of the polymerase.
Min Qing +7 more
wiley +1 more source
Predicting wildlife reservoirs and global vulnerability to zoonotic Flaviviruses. [PDF]
, 2018 Flaviviruses continue to cause globally relevant epidemics and have emerged or re-emerged in regions that were previously unaffected. Factors determining emergence of flaviviruses and continuing circulation in sylvatic cycles are incompletely understood.
Doyle, Megan M +5 more
core +2 more sources
Rational design of West Nile virus vaccine through large replacement of 3′ UTR with internal poly(A)
EMBO Molecular Medicine, 2021 The genus Flavivirus comprises numerous emerging and re‐emerging arboviruses causing human illness. Vaccines are the best approach to prevent flavivirus diseases.
Ya‐Nan Zhang +15 more
doaj +1 more source
Insect I‐Type Lysozymes Function as Antiviral Proteases by Forming Biomolecular Condensates
Advanced Science, EarlyView.Upon rice viral infection, the insect vector activates the Toll–MyD88–Dorsal signaling cascade, inducing i‐type lysozyme (Lyz‐I1) expression. Lyz‐I1 functions as an antiviral protease through its conserved catalytic dyad Glu/Asp (E/D), mediating cleavage of viral proteins at specific Lys (K) residues.
Yu Du +5 more
wiley +1 more source
Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors : the interaction with the RNAi mechanism [PDF]
, 2019 Arboviruses are capable to establish long-term persistent infections in mosquitoes that do not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the
Kolliopoulou, Anna +3 more
core +1 more source
Advanced Science, EarlyView.A novel ellipsometry platform functionalized with truncated PD‐L1 aptamers are developed to enable ultrasensitive detection of BALF‐derived exosomes. Through chemical ligand tailoring, mechanical sensing optimization, and tumor‐proximal fluid sampling, the system precisely stratifies ICI responders and non‐responders, offering superior sensitivity and ...
Euna Jeong +15 more
wiley +1 more source