Results 71 to 80 of about 15,113 (160)

Posttranslational modifications of heterologous proteins expressed in Nicotiana benthamiana

Plant Biotechnology Journal, EarlyView.
Summary The success of Nicotiana benthamiana as a workhorse for heterologous protein production is closely linked to its accessibility and tolerance to genetic manipulation, allowing efficient engineering of posttranslational protein modifications (PTMs) that are critical for the function and stability of heterologous proteins.
Kathrin Göritzer, Somanath Kallolimath, Richard Strasser   +2 more
wiley   +1 more source

Búsqueda de flavivirus en individuos con sospecha clínica de dengue y resultado negativo para el antígeno NS1 en Paraguay

Memorias del Instituto de Investigaciones en Ciencias de la Salud, 2017
Los flavivirus son responsables de una considerable morbi-mortalidad a nivel mundial. Entre ellos, el virus del dengue (DENV) es causante de graves problemas de salud pública en Paraguay.
Fátima María Cardozo Segovia, Alejandra María Rojas Segovia, Leticia Franco, Lilian Herebia, María Asunción Vallejos, Gloria Malvina Páez Acchiardi, Yvalena Guillén, Laura Patricia Mendoza Torres   +7 more
doaj  

Clinical Evaluation of Potential Interaction Between Bemnifosbuvir and Ruzasvir With an Assessment of Food Effect: Results of a Phase 1 Study in Healthy Participants

Clinical Pharmacology in Drug Development, Volume 14, Issue 6, Page 461-471, June 2025.
Abstract A combination of nucleotide hepatitis C virus (HCV) nonstructural protein (NS) 5B and 5A inhibitors is a preferred standard of care for treating chronic HCV. Bemnifosbuvir is a novel oral guanosine nucleotide prodrug with potent pan‐genotypic inhibitory activity against HCV NS5B.
Xiao‐Jian Zhou, Gaetano Morelli, Maureen Montrond, Shannan Lynch, Keith Pietropaolo, Bruce Belanger, Arantxa Horga, Janet Hammond   +7 more
wiley   +1 more source

Toll-Like Receptors and RIG-I-Like Receptors Play Important Roles in Resisting Flavivirus

Journal of Immunology Research, 2018
Flaviviridae family is a class of single-stranded RNA virus, which is fatal to human and animals and mainly prevalent in subtropic and tropic countries.
Hong-Yan Guo, Xing-Cui Zhang, Ren-Yong Jia   +2 more
doaj   +1 more source

Role of RNA-binding proteins during the late stages of Flavivirus replication cycle

Virology Journal, 2020
The genus Flavivirus encompasses several worldwide-distributed arthropod-borne viruses including, dengue virus, Japanese encephalitis virus, West Nile virus, yellow fever virus, Zika virus, and tick-borne encephalitis virus.
Mayra Diosa-Toro, K. R. Prasanth, Shelton S Bradrick, Shelton S Bradrick, Mariano A. Garcia Blanco, Mariano A. Garcia Blanco   +5 more
semanticscholar   +1 more source

Evaluating the Potential Adverse Effects of Favipiravir on Biochemical, Histopathological, and Spermatological Parameters in Male Rats' Testicular Tissue

Journal of Biochemical and Molecular Toxicology, Volume 39, Issue 6, June 2025.
ABSTRACT Favipiravir is a selective RNA polymerase inhibitor and a broad‐spectrum antiviral drug. Favipiravir reduces cell proliferation by inhibiting RNA transcription, particularly in rapidly proliferating cells such as spermatogonia. The aim of this study was to investigate the effects and mechanism of action of favipiravir (T‐705) on sperm quality ...
Ali Doğan Ömür, Gamze Uçak, Adem Kara, Elif Erbaş, Serkan Ali Akarsu, Seçkin Özkanlar, Nevra Aydemir Celep   +6 more
wiley   +1 more source

An RNA-Centric Dissection of Host Complexes Controlling Flavivirus Infection

Nature Microbiology, 2019
Flaviviruses, including dengue virus (DENV) and Zika virus (ZIKV), cause severe human disease. Co-opting cellular factors for viral translation and viral genome replication at the endoplasmic reticulum is a shared replication strategy, despite different ...
Y. Ooi, K. Majzoub, Ryan A. Flynn, Miguel A. Mata, J. Diep, Jason Li, Nicholas van Buuren, Neil Rumachik, Alex G. Johnson, A. Puschnik, C. Marceau, Luwanika Mlera, J. M. Grabowski, K. Kirkegaard, M. Bloom, P. Sarnow, C. Bertozzi, J. Carette   +17 more
semanticscholar   +1 more source

Mosquito‐Borne Diseases in Canada: Integrated Perspectives on Disease Management and Influences of Environmental and Anthropogenic Factors Affecting the Transmission Cycle

Public Health Challenges, Volume 4, Issue 2, June 2025.
ABSTRACT Globally, mosquito‐borne diseases (MBD) cause the highest morbidity and mortality in humans and animals. Currently, in Canada, endemic MBDs that are significant public health problems are all zoonoses and are caused primarily by West Nile virus, Eastern equine encephalitis virus, and Californian serogroup viruses, including the Jamestown ...
Antoinette Ludwig, David Lapen
wiley   +1 more source

The glycosylation deficiency of flavivirus NS1 attenuates virus replication through interfering with the formation of viral replication compartments

Journal of Biomedical Science
Background Flavivirus is a challenge all over the world. The replication of flavivirus takes place within membranous replication compartments (RCs) derived from endoplasmic reticulum (ER).
Shuhan Huang, Pan-Deng Shi, Xiao-Xuan Fan, Yang Yang, Cheng-Feng Qin, Hui Zhao, Lei Shi, Yali Ci   +7 more
doaj   +1 more source

Renaming of the genus Flavivirus to Orthoflavivirus and extension of binomial species names within the family Flaviviridae

Archives of Virology, 2023
T. Postler, M. Beer, B. Blitvich, J. Bukh, X. D. de Lamballerie, J. Drexler, A. Imrie, A. Kapoor, G. Karganova, P. Lemey, V. Lohmann, P. Simmonds, Donald B. Smith, J. Stapleton, J. Kuhn   +14 more
semanticscholar   +1 more source