Results 81 to 90 of about 60,474 (247)

Predicting wildlife reservoirs and global vulnerability to zoonotic Flaviviruses. [PDF]

, 2018
Flaviviruses continue to cause globally relevant epidemics and have emerged or re-emerged in regions that were previously unaffected. Factors determining emergence of flaviviruses and continuing circulation in sylvatic cycles are incompletely understood.
Doyle, Megan M, Drape, Gaylen W, Johnson, Christine K, Pandit, Pranav S, Smart, Katrina M, Young, Cristin CW   +5 more
core   +2 more sources

Human Cyclophilins—An Emerging Class of Drug Targets

Medicinal Research Reviews, Volume 46, Issue 2, Page 475-512, March 2026.
ABSTRACT Cyclophilins are a family of enzymes with peptidyl‐prolyl isomerase activity found in all cells of all organisms. To date, 17 cyclophilin isoforms have been identified in the human body, participating in diverse biological processes. Consequently, cyclophilins have emerged as promising targets for drug development to address a wide array of ...
Katarina Jurkova, Hana Navratilova, Kamil Musilek, Ondrej Benek   +3 more
wiley   +1 more source

Impact of flavivirus vaccine-induced immunity on primary Zika virus antibody response in humans.

PLoS Neglected Tropical Diseases, 2020
BackgroundZika virus has recently spread to South- and Central America, causing congenital birth defects and neurological complications. Many people at risk are flavivirus pre-immune due to prior infections with other flaviviruses (e.g.
Stefan Malafa, Iris Medits, Judith H Aberle, Stephan W Aberle, Denise Haslwanter, Georgios Tsouchnikas, Silke Wölfel, Kristina L Huber, Elena Percivalle, Pascal Cherpillod, Melissa Thaler, Lena Roßbacher, Michael Kundi, Franz X Heinz, Karin Stiasny   +14 more
doaj   +1 more source

Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors : the interaction with the RNAi mechanism [PDF]

, 2019
Arboviruses are capable to establish long-term persistent infections in mosquitoes that do not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the
Kolliopoulou, Anna, Liu, Jisheng, Smagghe, Guy, Swevers, Luc   +3 more
core   +1 more source

Toward Dual‐Function Nanoparticle Platforms for Arboviral Diagnostics and Vaccines: Advances, Challenges, and Future Prospects

Nano Select, Volume 7, Issue 2, February 2026.
This review explores nanoparticle (NP)‐based biosensors and nanovaccine platforms for arboviral infections, highlighting their design, performance, and translational potential. By comparing case studies across viruses, it identifies gold‐standard nanomaterials such as gold NPs (AuNPs), zinc oxide NPs (ZnONPs), molybdenum disulfide (MoS2) nanocomposites,
Peyman Halvaeikhanekahdani, Sajad Zandi, Qadeer Ahmad, Hadiseh Payravand   +3 more
wiley   +1 more source

Immunological and Safety Considerations When Selecting the Dose Formulation of a Purified Inactivated Zika Virus Vaccine (PIZV)

Microorganisms
We previously reported the first-in-human assessment of three doses (2, 5, and 10 µg) of purified inactivated Zika virus vaccine (PIZV or TAK-426) in the Phase 1 ZIK-101 study (NCT03343626).
Camilo J. Acosta, Francesco Nordio, Eloi Kpamegan, Kelley J. Moss, Pradeep Kumar, Kazuhiro Hirata   +5 more
doaj   +1 more source

Zika virus surveillance post‐epidemic in blood donors from São Paulo, Brazil 2016–2020

Transfusion Medicine, Volume 36, Issue 1, Page 59-65, February 2026.
Abstract Introduction Zika virus (ZIKV) is primarily transmitted through the bite of the Aedes aegypti mosquito, though transmission via blood transfusion has also been documented. During the 2015 ZIKV epidemic in Brazil, severe complications were observed in pregnant women, leading to fetal microcephaly. This study evaluated the persistence of ZIKV in
Suzete Cleusa Ferreira, José Eduardo Levi, Anna Shoko Nishiya, Cesar de Almeida‐Neto, Jerenice Esdras Ferreira, Juliana Derriga, Nanci A. Salles, Silvia Petrossi Gallo Polato, Katia C. Dantas, Edmir Boturão‐Neto, Martha Mathias Rocha, Vanderson Rocha, Alfredo Mendrone‐Jr   +12 more
wiley   +1 more source

Seroprevalence of Zika virus in wild African green monkeys and baboons [PDF]

, 2017
Zika virus (ZIKV) has recently spread through the Americas and has been associated with a range of health effects, including birth defects in children born to women infected during pregnancy. Although the natural reservoir of ZIKV remains poorly defined,
Adam L. Bailey, Andrea M. Weiler, Anna J. Jasinska, Clifford J. Jolly, Connor R. Buechler, Cristian Apetrei, David H. O’Connor, Gabrielle L. Barry, Jane E. Phillips-Conroy, Jeffrey Rogers, John Schoggins, Laurel M. Stewart, Meghan E. Breitbach, Nelson B. Freimer, Thomas C. Friedrich   +14 more
core   +3 more sources

A blood safety perspective on emerging arboviral infections in the United Kingdom

Transfusion Medicine, Volume 36, Issue 1, Page 10-19, February 2026.
Abstract A core focus of the blood services is to maintain the blood supply whilst simultaneously being vigilant for potential threats to blood safety. At present, West Nile virus (WNV), Usutu virus (USUV), Dengue virus (DENV) and Tick‐borne encephalitis virus (TBEV) are considered primary arboviral threats to blood safety in the UK and Northern Europe.
Piya Rajendra, Shannah Secret, Su Brailsford, Tanya Golubchik, Peter Simmonds, Heli Harvala   +5 more
wiley   +1 more source

Determinants of the population growth of the West Nile virus mosquito vector Culex pipiens in a repeatedly affected area in Italy [PDF]

, 2014
Background The recent spread of West Nile Virus in temperate countries has raised concern. Predicting the likelihood of transmission is crucial to ascertain the threat to Public and Veterinary Health.
Bonfanti, L., Capelli, G., Ferguson, H.M., Marangon, S., Montarsi, F., Mulatti, P.   +5 more
core   +1 more source