Results 121 to 130 of about 3,670,778 (207)

Reverse Genetics of Orthoflaviviruses: Strategies for Constructing Functional or Infectious cDNA

Journal of Medical Virology, Volume 98, Issue 6, June 2026.
ABSTRACT Reverse genetics (RG) systems have transformed RNA virus research by enabling the recovery of recombinant viruses entirely from cloned cDNA. These platforms allow precise, hypothesis‐driven manipulation of viral genomes and support systematic phenotypic analyses in vitro and in vivo.
Young‐Min Lee
wiley   +1 more source

Signal transduction in immune cells and extracellular matrix role in viral tick-borne encephalitis

Инфекция и иммунитет
Tick-borne encephalitis virus, a member of the genus Orthoflavivirus, consisting of Flaviviridae, is the causative agent of tick-borne encephalitis, a neuroviral disease, the severity of which varies from mild (febrile form) to severe and life ...
Jeanne P. Belokrylova
doaj   +1 more source

Organoids: From Bench to Bedside Applications

MedComm, Volume 7, Issue 6, June 2026.
Organoids, as a groundbreaking biomedical research platform, utilize adult stem cells (ASCs), embryonic stem cells (ESCs), and induced pluripotent stem cells (iPSCs) as sources. By integrating specific growth and differentiation signals within an extracellular matrix (e.g., Matrigel), organoids guide cells to self‐assemble into three‐dimensional ...
Kelin Li, Rui Cao, Maochen Li, Zichao Tian, Huahao Fan, Bixia Hong, Xiaojuan Liu   +6 more
wiley   +1 more source

Acute encephalitis, a poliomyelitis-like syndrome and neurological sequelae in a hamster model for flavivirus infections

, 2003
Infection of hamsters with the murine flavivirus Modoc results in (meningo)encephalitis, which is, during the acute phase, frequently associated with flaccid paralysis, as also observed in patients with West Nile virus encephalitis. Twenty percent of the
Leyssen, Pieter, De Clercq, Erik, Meyding-Lamadé, Uta, Charlier, Nathalie, Verbeken, Eric, Sciot, Raphael, Neyts, Johan, Paeshuyse, Jan, Rau, Philipp, Croes, Romaric, Heiland, Sabine   +10 more
core   +1 more source

When conservation meets contagion: Mapping yellow fever risk to guide vaccination in an endangered primate

Journal of Applied Ecology, Volume 63, Issue 6, June 2026.
Spatial projections revealed high‐risk areas for YF transmission, highlighting priority zones for targeted vaccination efforts in GLTs. By integrating disease ecology into conservation planning, this study offers a scalable framework for spatially informed interventions aimed at mitigating disease‐driven declines in threatened species.
Maxime Pierron, Aurore Ponchon, Carlos R. Ruiz‐Miranda, Andreia Martins, Cédric Sueur, Valéria Romano   +5 more
wiley   +1 more source

A Modular Design of a Cholera Toxin B Subunit‐Scaffolded Sub‐Virion Nanoparticle Vaccine Against West Nile Virus

Microbial Biotechnology, Volume 19, Issue 6, June 2026.
A recombinant West Nile virus (WNV) subunit vaccine was developed by displaying ED3 on a CTB scaffold. The fusion protein formed soluble nanoparticles in E. coli, eliciting strong, balanced, and specific neutralizing antibodies without cross‐reactivity, offering a safe, scalable subunit vaccine platform.
Hyun Byun, Tae Hoon Kim, Jemin Sung, Jung‐Min Lee, Sang‐Mu Shim, Sin Hae Kang, Hanul Kang, Dah Hyun Moon, Seong Hyun Park, Doda Kim, Sung Jae Kim, Seunghoo Kim, Gyoonhee Han, Baik Lin Seong   +13 more
wiley   +1 more source

The endoplasmic reticulum (ER): a crucial cellular hub in flavivirus infection and potential target site for antiviral interventions

npj Viruses
Dengue virus (DENV) is the most prevalent arthropod-borne flavivirus and imposes a significant healthcare threat worldwide. At present no FDA-approved specific antiviral treatment is available, and the safety of a vaccine against DENV is still on debate.
Marijke Verhaegen, K. Vermeire
semanticscholar   +1 more source

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, Volume 40, Issue 2, Page 350-359, June 2026.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source

Bis-benzylisoquinoline alkaloids inhibit flavivirus entry and replication by compromising endolysosomal trafficking and autophagy

Virologica Sinica
Flaviviruses, such as dengue virus (DENV), Zika virus (ZIKV), and Japanese encephalitis virus (JEV), represent a substantial public health challenge as there are currently no approved treatments available.
Lihong Huang, Le-le Liu, Junhai Zhu, Nanjun Chen, Jie Chen, C. Chan, Fei Gao, Youqin Yin, Jiufeng Sun, Rongxin Zhang, Kehui Zhang, Wenbao Qi, Jianbo Yue   +12 more
semanticscholar   +1 more source

Cholesterol-Lowering Drugs as Potential Antivirals: A Repurposing Approach against Flavivirus Infections. [PDF]

Viruses, 2023
Osuna-Ramos JF, Farfan-Morales CN, Cordero-Rivera CD, De Jesús-González LA, Reyes-Ruiz JM, Hurtado-Monzón AM, Palacios-Rápalo SN, Jiménez-Camacho R, Meraz-Ríos MA, Del Ángel RM.   +9 more
europepmc   +1 more source