Results 101 to 110 of about 3,670,778 (207)

Sustainable, three-component, one-pot procedure to obtain active anti-flavivirus agents

, 2021
The mosquito-borne viruses belonging to the genus Flavivirus such as Dengue virus (DENV) and Zika virus (ZIKV) cause human infections ranging from mild flu-like symptoms to hemorrhagic fevers, hepatitis, and neuropathies. To date, there are vaccines only
Violetta Cecchetti, Manfroni, G, Maria Sole Burali, Burali, MS, Kitti Wing Ki Chan, Gwee, CP, Vasudevan, SG, Chin Piaw Gwee, Oriana Tabarrini, Massari, S, Barreca, ML, Subhash G. Vasudevan, Stefano Sabatini, Maria Letizia Barreca, Tommaso Felicetti, Sylvie Alonso, Cecchetti, V, Alonso, S, Tabarrini, O, Ki Chan, KW, Giuseppe Manfroni, Felicetti, T, Serena Massari, Sabatini, S   +23 more
core   +1 more source

Korat‐Scrub Typhus Score: A Clinical Tool for Predicting Scrub Typhus in Patients With Acute Undifferentiated Febrile Illness

Tropical Medicine &International Health, EarlyView.
ABSTRACT Objective Scrub typhus is a major cause of acute undifferentiated febrile illness (AUFI) in the Asia–Pacific region. Nonspecific presentation, limited diagnostic accuracy and delayed treatment increase morbidity and mortality. This study aimed to develop a simple clinical score for early diagnosis in adults with AUFI. Methods A cross‐sectional
Wilawan Thipmontree, Ekkarat Wongsawat, Saowaluk Silpasakorn, Yupin Suputtamongkol   +3 more
wiley   +1 more source

Estudo in vitro das citocinas envolvidas na resposta inflamatória de macrófagos murinos à infecção pelo vírus da dengue. [PDF]

, 2012
TCC(graduação) - Universidade Federal de Santa Catarina. Centro de Ciências Biológicas. Biologia.A dengue é uma doença que tem como agente etiológico o Dengue virus (DENV), da família Flaviviridae, do gênero Flavivirus.
Souza, Ingrid Larissa Melo de
core  

Unusual MRI features in a case of presumed canine tick‐borne meningoencephalomyelitis

Veterinary Record Case Reports, Volume 14, Issue 3, August 2026.
Abstract A 7‐year‐old, standard, wire‐haired dachshund presented with quickly progressive multifocal central nervous system signs, which localised to the brainstem and cervical myelopathy, including reduced cervical and thoracic limb muscle tone and withdrawal reflexes. Magnetic resonance imaging revealed bilateral, approximately symmetric, T2‐weighted
Jon Prager, Alex Smith, Hélène Vandenberghe   +2 more
wiley   +1 more source

Immunological Interactions Between Gammadelta T Cells and West Nile Virus in the Infected Host

Reviews in Medical Virology, Volume 36, Issue 4, July 2026.
ABSTRACT Between mosquitoes and birds, West Nile virus (WNV) is a neurotropic flavivirus, an arthropod‐borne pathogen involved in an enzootic cycle. Additionally, it can infect both people and horses, leading to severe illness. Since 1999, WNV has spread across North and South America, including Mexico and the Caribbean.
E. Cimini, E. Tartaglia, F. Cristofanelli, S. Gili, F. Maggi   +4 more
wiley   +1 more source

The Regulation of Flavivirus Infection by Hijacking Exosome-Mediated Cell–Cell Communication: New Insights on Virus–Host Interactions

Viruses, 2020
The arthropod-borne flaviviruses are important human pathogens, and a deeper understanding of the virus–host cell interaction is required to identify cellular targets that can be used as therapeutic candidates.
José Manuel Reyes-Ruiz, Juan Fidel Osuna-Ramos, Luis Adrián De Jesús-González, Selvin Noé Palacios-Rápalo, Carlos Daniel Cordero-Rivera, Carlos Noe Farfan-Morales, Arianna Mahely Hurtado-Monzón, Carla Elizabeth Gallardo-Flores, Sofía L. Alcaraz-Estrada, Juan Santiago Salas-Benito, Rosa María del Ángel   +10 more
doaj   +1 more source

Single-cell transcriptional dynamics of flavivirus infection

eLife, 2017
Dengue and Zika viral infections affect millions of people annually and can be complicated by hemorrhage and shock or neurological manifestations, respectively. However, a thorough understanding of the host response to these viruses is lacking, partly because conventional approaches ignore heterogeneity in virus abundance across cells.
Fabio Zanini, Szu-Yuan Pu, Elena Bekerman, Shirit Einav, Stephen R. Quake   +4 more
openaire   +3 more sources

Small Molecule Inhibitor of ATPase Activity of HSP70 as a Broad-Spectrum Inhibitor against Flavivirus Infections

, 2020
Flaviviruses including Zika virus, Dengue virus, Japanese Encephalitis virus, and Yellow Fever virus cause heavy burdens to public health around the world. No specific antiviral drug is available in the clinic against these flavivirus infections.
Wei Li (7081), Yuexiang Li (1757773), Lei Zhao, Song Li, Wu Zhong, Yongfen Xu (480499), Jingjing Yang (119262), Jin Zhong (9647), Yuexiang Li, Jingjing Yang, Ruiyuan Cao, Yunzheng Yan (8393577), Qingsong Dai, Yunzheng Yan, Wei Li, Jin Zhong, Ruiyuan Cao (4783455), Yongfen Xu, Song Li (65582), Lei Zhao (144153), Qingsong Dai (8393580), Wu Zhong (2535388)   +21 more
core   +1 more source

Synthesis and Evaluation of Aromatic Sulfonamide and Disulfonamide Derivatives as Dengue Virus NS3–NS5 Interaction Inhibitors

ChemMedChem, Volume 21, Issue 11, 15 June 2026.
A synthetic methodology for the preparation of asymmetric benzene‐1,4‐disulfonamides was developed and applied to generate potential anti‐dengue virus (DENV) compounds. Guided by computer‐assisted structural rationalization, we designed synthetically more accessible analogs with reduced toxicity that interact with the DENV NS5 domain, thereby ...
Jakub Janáč, Jan Drahorád, Jakub Harvalík, Tereza Horáčková, Manfred Brinker, Arianna Loregian, Andrea Brancale, Beatrice Mercorelli, Petra Cuřínová   +8 more
wiley   +1 more source

Isolation of Metabolites With Antiviral Activity From the Brown Algae Dictyota fasciola and Dictyota mediterranea

Chemistry &Biodiversity, Volume 23, Issue 6, June 2026.
Twenty‐one compounds, including six dolabellanes diterpenes and one germacrene sesquiterpene that are new natural products, are reported from the brown algae Dictyota fasciola and Dictyota mediterranea collected from the Aegean Sea. Among them, some exhibit considerable antiviral activity against RNA (HCoV‐NL63, ZIKV) and DNA (HSV‐1) viruses.
Aikaterini Koutsaviti, Elsi‐Evangelia Andriotaki, Maria Harizani, Katarzyna Owczarek, Magdalena Pachota, Aleksandra Synowiec, Artur Szczepański, Paweł Botwina, Krzysztof Pyrć, Vassilios Roussis, Efstathia Ioannou   +10 more
wiley   +1 more source