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Studies on the mosquito-borne flavivirus serology useful for diagnosis of flavivirus infections

Studies on the mosquito-borne flavivirus serology useful for diagnosis of flavivirus infections
病原性蚊媒介性フラビウイルス（MBFV）は、異なるウイルス種間で構造タンパク質のアミノ酸配列が高度に保存されている。そのため、これらの構造タンパク質を認識する抗体は、交差反応性を示す。その交差反応性抗体は、幅広いフラビウイルスの構造タンパク質に結合するため、ウイルス種特異的な抗体を検出可能な血清診断法は未だ開発されていない。本研究では、これまで報告されてきたMBFV間ではなく、MBFVと昆虫特異的フラビウイルス（ISFV）間の抗原性を比較し、異なる抗原性を有するウイルスアミノ酸配列を用いて、交差反応性抗体の非特異的な結合を低減させるウイルス抗原作出を試みた。 第一章 MBFV と比較したlineage II ISFV の血清学的性状解析 　　第一章では、分子系統学的にMBFVに近縁なlineage ...
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Compensating for cross-reactions using avidity and computation in a suspension multiplex immunoassay for serotyping of Zika versus other flavivirus infections. [PDF]

Med Microbiol Immunol, 2017
Rönnberg B, Gustafsson Å, Vapalahti O, Emmerich P, Lundkvist Å, Schmidt-Chanasit J, Blomberg J.   +6 more
europepmc   +1 more source

Improved and customized dengue serodiagnostics through combined NS1/IgM testing and novel dual-cut-off IgG ELISA. [PDF]

PLoS Negl Trop Dis
Saschenbrecker S, Muigg N, Klemens O, Klemens JM.   +3 more
europepmc   +1 more source

Mathematical modeling of sequential Dengue-Zika infections: dynamic insights into antibody-dependent enhancement and neutralization effects. [PDF]

Sci Rep
Deolia P, Singh A, Mubayi A.
europepmc   +1 more source

The contribution of viral toxins to infection and pathogenesis. [PDF]

mBio
Biering SB, Puerta-Guardo H, Pahmeier F, Kril V, Harris E.   +4 more
europepmc   +1 more source

Characterization of arbovirus infections in patients within Haiti by screening discarded malaria rapid diagnostic test cassettes. [PDF]

PLoS Negl Trop Dis
Matulis GA, Smith HP, Hall G, Katich RS, Delp KL, Douglas CE, Williams J, Hirsch S, Kumar R, Pshea-Smith I, Lilak AA, Okech BA, Ricks K, Stefan CP, Existe A, Kugelman JR, Sutherland I, Dunford J, Boncy J, von Fricken ME, Koehler JW.   +20 more
europepmc   +1 more source

Flavivirus-Induced ER Stress and Unfolded Protein Response: A Central Hub Linking Lipid Droplet Remodeling and Viral Replication. [PDF]

Viruses
Muhammad I, Craft K, Pei S, Cruz-Cosme R, Tang Q.   +4 more
europepmc   +1 more source

The Flavivirus NS3 Protein: Its Multifaceted Roles and Therapeutic Potential. [PDF]

J Med Virol
Lee H, Cho H, Gack MU.
europepmc   +1 more source

Detection and genetic characterization of Tembusu virus and other flaviviruses from mosquitoes in Lao PDR. [PDF]

PLoS One
Vanhnollat C, Chonephetsarath S, Somlor S, Vungkyly V, Soulaphy T, Vongsanga S, Etobayeva IV, Bigot T, Wong G, Letizia AG, Brey PT, Buchy P, Vongphayloth K.   +12 more
europepmc   +1 more source

Functional Antibody-Dependent Enhancement as an Immune Assessment Platform: Development, Standardization, and Translational Interpretation in Flavivirus Research. [PDF]

Pathogens
Moi ML.
europepmc   +1 more source