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Flavivirus infections and diagnostic challenges for dengue, West Nile and Zika Viruses [PDF]

Npj Viruses
Flaviviruses are arthropod-borne viruses, belonging to the Flaviviridae family. Dengue virus (DENV), West Nile virus (WNV), and Zika virus (ZIKV) are members of the Flavivirus genus, which are primarily transmitted by mosquitos.
Ferralita S. Madere, Aurea Virgínia Andrade da Silva, Efemena Okeze, E. Tilley, A. Grinev, K. Konduru, Mayra García, Maria R Rios   +7 more
semanticscholar   +2 more sources

Role of pattern recognition receptors in flavivirus infections.

Virus Research, 2014
The flaviviral encephalitis has now become a major health concern in global scale. The efficient detection of viral infection and induction of the innate antiviral response by host's innate immune system are crucial to determine the outcome of infection.
Arshed Nazmi, K. Dutta, B. Hazra, A. Basu   +3 more
semanticscholar   +4 more sources

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Molecular diagnostics for the detection of human flavivirus infections.

Expert Opinion on Medical Diagnostics, 2007
Flaviviruses constitute a genus of viruses that are important etiologic agents of human disease, causing clinical disease ranging from fever to severe manifestations, such as encephalitis and hemorrhagic fever. Serology is presently the most frequently used means of diagnosing flavivirus infections. However, other diagnostic tests may be employed, such
S. Sekaran, H. Artsob
semanticscholar   +5 more sources

Serologic Evidence of Flavivirus Infections in Peridomestic Rodents in Merida, Mexico

Journal of Wildlife Diseases, 2016
N. Cigarroa-Toledo, L. Talavera-Aguilar, C. Baak-Baak, J. García-Rejón, S. Hernández-Betancourt, B. Blitvich, C. Machaín-Williams   +6 more
semanticscholar   +3 more sources

A Small Molecule Inhibitor of ATPase activity of HSP70 As Broad-Spectrum Inhibitor Against Flavivirus Infections.

ACS Infectious Diseases, 2020
Flaviviruses including Zika virus, Dengue virus, Japanese Encephalitis virus and Yellow Fever virus cause heavy burdens to public health around the world. No specific antiviral drug was available in clinic against these flavivirus infections.
Jingjing Yang, Yongfen Xu, Yunzheng Yan, Wei Li, Lei Zhao, Qingsong Dai, Yuexiang Li, Song Li, Jin Zhong, Ruiyuan Cao, Wu Zhong   +10 more
semanticscholar   +1 more source

Immunopathology of flavivirus infections

Immunology & Cell Biology, 2006
With the recent emergence of the flavivirus, West Nile virus (WNV), in particular, the New York strain of Lineage I WNV in North America in 1999, there has been a significant increase in activity in neurotropic flavivirus research. These viruses cause encephalitis that can result in permanent neurological sequelae or death. Attempts to develop vaccines
Nicholas J C, King, Daniel R, Getts, Meghann T, Getts, Sabita, Rana, Bimmi, Shrestha, Alison M, Kesson   +5 more
openaire   +2 more sources

Dynamics of Flavivirus Infection in Mosquitoes

2003
Abstract Mosquito-borne flaviviruses are emerging as the cause of some of the most serious and widespread arthropod-borne viral diseases in the world. Flavivirus outbreaks are influenced by intrinsic (e.g., viral strain, vector competence, host susceptibility) and extrinsic (e.g., temperature, rainfall, human land use) factors that affect mosquito ...
Laura D, Kramer, Gregory D, Ebel
openaire   +2 more sources

Serological Detection of Flavivirus Infections in Saudi Baboons

EcoHealth, 2021
To evaluate the risk to public health from Flaviviruses in the southwest region of the Kingdom of Saudi Arabia, we screened as sentinels, 50 commensal hamadryas baboons located at a peri-domestic site on the outskirts of Ta'if City in February 2013. Of the baboons, 12% [95% CI 5, 24], 0% [95% CI 0, 7] and 10% [95% CI 3, 22] were seropositive in a pan ...
Ayodeji Oluwadare Olarinmoye, Henk Niphuis, Ernst Verschoor, Babasola Oluseyi Olugasa, Olayinka Olabisi Ishola, Ali Abdullah Aldosari, Ahmed Boug, Bamidele Nyemike Ogunro, Khalid Al-Hezaimi   +8 more
openaire   +2 more sources

Intrinsically disordered protein domains in flavivirus infection

Archives of Biochemistry and Biophysics, 2020
Intrinsically disordered protein regions are at the core of biological processes and involved in key protein-ligand interactions. The Flavivirus proteins, of viruses of great biomedical importance such as Zika and dengue viruses, exemplify this. Several proteins of these viruses have disordered regions that are of the utmost importance for biological ...
Ivo C, Martins, Nuno C, Santos
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Antibody Prophylaxis and Therapy for Flavivirus Encephalitis Infections

Annals of the New York Academy of Sciences, 2001
Abstract: The outbreak of West Nile (WN) encephalitis in the United States has rekindled interest in developing direct methods for prevention and control of human flaviviral infections. Although equine WN vaccines are currently being developed, a WN vaccine for humans is years away. There is also no specific therapeutic agent for flaviviral infections.
J T, Roehrig, L A, Staudinger, A R, Hunt, J H, Mathews, C D, Blair   +4 more
openaire   +2 more sources