The flavivirus NS1 protein: molecular and structural biology, immunology, role in pathogenesis and application as a diagnostic biomarker [PDF]
, 2013 The flavivirus nonstructural glycoprotein NS1 is an enigmatic protein whose structure and mechanistic function have remained somewhat elusive ever since it was first reported in 1970 as a viral antigen circulating in the sera of dengue-infected patients.
Muller, David A., Young, Paul R.
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Flaviviruses of public health concern in South Africa: Present and future threats
Southern African Journal of Infectious DiseasesBackground: The resurgence and widespread transmission of flaviviruses over the past few decades are particularly concerning. Aim: This review discusses the structure, aetiology, transmission, detection, diagnosis and prevention strategies for ...
Angela Sibanda-Makuvise +2 more
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Suppression of Type I Interferon Signaling by Flavivirus NS5. [PDF]
, 2018 Type I interferon (IFN-I) is the first line of mammalian host defense against viral infection. To counteract this, the flaviviruses, like other viruses, have encoded a variety of antagonists, and use a multi-layered molecular defense strategy to ...
Hai, Rong +3 more
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Yaoundé-like virus in resident wild bird, Ghana [PDF]
, 2012 Tissue and swab samples from 551 wild birds collected in Ghana (October-November 2007) were assayed for alphaviruses, flaviviruses, and influenza A viruses using polymerase chain (PCR) techniques.
Ampofo, William +9 more
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Biosafety Concerns Involving Genetically Modified Mosquitoes to Combat Malaria and Dengue in Developing Countries [PDF]
, 2011 Malaria and dengue are the most prevalent mosquito-borne infections worldwide. Because traditional vector control methods have proven to be insufficient to control mosquito populations in endemic areas, scientists are actively working in the design of ...
Gostin, Lawrence O., Ostera, Graciela R.
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Zika Virus IgM Detection and Neutralizing Antibody Profiles 12–19 Months after Illness Onset
Emerging Infectious Diseases, 2019 Data on the duration of detectable Zika virus–specific IgM in infected persons are limited. Neutralizing antibody cross-reactivity occurs between Zika virus and related flaviviruses, but the degree to which this confounds diagnosis is uncertain.
Isabel Griffin +9 more
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Arboviruses and the challenge to establish systemic and persistent infections in competent mosquito vectors : the interaction with the RNAi mechanism [PDF]
, 2019 Arboviruses are capable to establish long-term persistent infections in mosquitoes that do not affect significantly the physiology of the insect vectors. Arbovirus infections are controlled by the RNAi machinery via the production of viral siRNAs and the
Kolliopoulou, Anna +3 more
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Cryo-EM structure of the mature dengue virus at 3.5-Å resolution. [PDF]
, 2013 Regulated by pH, membrane-anchored proteins E and M function during dengue virus maturation and membrane fusion. Our atomic model of the whole virion from cryo-electron microscopy at 3.5-Å resolution reveals that in the mature virus at neutral ...
Bi, Guoqiang +7 more
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Genetic Resistance to Flaviviruses [PDF]
Monoclonal Antibodies in Immunodiagnosis & Immunotherapy, 2014 I was a graduate student in the Department of Microbiology at the University of Pennsylvania in the late 1960s and chose to do my dissertation research with Hilary Koprowski at The Wistar Institute, even though I was warned that this might not be the best training situation for me.
openaire +2 more sources
Clinical perspectives of emerging pathogens in bleeding disorders. [PDF]
, 2006 As a result of immunological and nucleic-acid screening of plasma donations for transfusion-transmissible viruses, and the incorporation of viral reduction processes during plasma fractionation, coagulation-factor concentrates (CFC) are now judged safe ...
Bozzette, Samuel +11 more
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