Results 81 to 90 of about 26,407 (220)

Rapid Generation of Recombinant Flaviviruses Using Circular Polymerase Extension Reaction

, 2023
The genus Flavivirus is a group of arthropod-borne single-stranded RNA viruses, which includes important human and animal pathogens such as Japanese encephalitis virus (JEV), Zika virus (ZIKV), Dengue virus (DENV), yellow fever virus (YFV), West Nile ...
Guo-Qing Xiong, Chun-Lin Cheng, Hui-Peng Chen, Qing-Yang Wang, Guang Zhao, Gang Liu, Mei-Juan He, Hao Cheng, Yuan-Yuan Lu, Hao-Long Dong, Jia-Zhen Cui, Xiang-Hua Xiong, Lian-Cheng Zhang, Zhi-Li Chen, Zhi-Xin Meng, Ao Hu, Chen Zhu   +16 more
core   +1 more source

Neuronal Apoptotic Bodies Facilitate Japanese Encephalitis Virus Infection and Pathogenicity

Journal of Extracellular Vesicles, Volume 15, Issue 9, September 2026.
ABSTRACT Japanese encephalitis (JE) caused by Japanese encephalitis virus (JEV) infection remains one of the major types of viral encephalitis. The mechanisms underlying JEV infection and pathogenesis have not been fully elucidated, resulting in the absence of specific therapies for JE. Neuronal apoptosis is a well‐established outcome of JEV infection;
Chuan Zeng, Xiaowei Nan, Ting Wang, Junyao Xiong, Shuo Zhu, Chengjie Yang, Bibo Zhu, Youhui Si, Shengbo Cao, Jing Ye   +9 more
wiley   +1 more source

A New Clade of Insect-Specific Flaviviruses from Australian Anopheles Mosquitoes Displays Species-Specific Host Restriction

mSphere, 2017
Flaviviruses are arthropod-borne viruses found worldwide and are responsible for significant human and veterinary diseases, including dengue, Zika, and West Nile fever. Some flaviviruses are insect specific and replicate only in mosquitoes.
Agathe M. G. Colmant, Jody Hobson-Peters, Helle Bielefeldt-Ohmann, Andrew F. van den Hurk, Sonja Hall-Mendelin, Weng Kong Chow, Cheryl A. Johansen, Jelke Fros, Peter Simmonds, Daniel Watterson, Chris Cazier, Kayvan Etebari, Sassan Asgari, Benjamin L. Schulz, Nigel Beebe, Laura J. Vet, Thisun B. H. Piyasena, Hong-Duyen Nguyen, Ross T. Barnard, Roy A. Hall   +19 more
doaj   +1 more source

Dengue Seroprevalence Among Blood Donors in the Lazio Region (Italy): Is There an Iceberg Beneath the Surface?

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT During 2023, dengue virus (DENV) autochthonous circulation was detected in Lazio, Italy. To investigate the magnitude of the phenomenon, anti‐DENV serological status of blood donors residing in previously affected Rome municipalities was evaluated.
Martina Spaziante, Lugi Rosa, Francesca Colavita, Ilaria Mussetto, Gabriella De Carli, Valentina Vantaggio, Alessandro Agresta, Sabrina Coen, Silvia Cammisa, Alessandra D'Abramo, Gaetano Maffongelli, Stefania Vaglio, Stefano Iaboni, Ida Casorelli, Luca Mele, Luciana Teofili, Paola Scognamiglio, Andrea Siddu, Emanuele Nicastri, Fabrizio Maggi, Enrico Girardi, ARBODONORS Working Group, Deborah Ilaria Gadaleta, Diletta D'Epiro, Enrico Duranti, Manuela Cornacchia, Tecla Maria Fontana, Maria Laura Foddai, Francesca Frangiolini, Giuseppina Antonia Natale, Mafalda De Rienzo, Francesco Vairo   +31 more
wiley   +1 more source

Flavivirus Receptors: Diversity, Identity, and Cell Entry

Frontiers in Immunology, 2018
Flaviviruses are emerging and re-emerging arthropod-borne pathogens responsible for significant mortality and morbidity worldwide. The genus comprises more than seventy small, positive-sense, single-stranded RNA viruses, which are responsible for a ...
Mathilde Laureti, Mathilde Laureti, Divya Narayanan, Divya Narayanan, Julio Rodriguez-Andres, Julio Rodriguez-Andres, John K. Fazakerley, John K. Fazakerley, Lukasz Kedzierski, Lukasz Kedzierski   +9 more
doaj   +1 more source

Eugenol‐Derived Piperazine Mannich Bases as Selective Inhibitors of Mayaro Virus: In Vitro Antiviral Evaluation and Mechanistic Insights

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Arboviruses represent an ongoing global health challenge, particularly in tropical regions where diseases caused by Chikungunya virus (CHIKV) and Mayaro virus (MAYV) continue to emerge. Given the absence of licensed antiviral therapies, the identification of effective small molecules remains critical.
Adriana Cotta Cardoso Reis, Amália Luíza de Sousa da Silva, Camila Portruneli, Augusto Vieira Pontes Silva, Saulo Fehelberg Pinto Braga, Igor Rodrigues Lapa, Thiago Belarmino de Souza, Lucas Lopardi Franco, Diogo Teixeira Carvalho, Geraldo Célio Brandão   +9 more
wiley   +1 more source

Targeted Lymph Node Immunization with Serotype-Specific Dengue VLP Vaccines Enhances Antibody Avidity and Specificity

Vaccines
Introduction: Dengue virus (DENV) remains a global health threat, with four distinct serotypes (DENV1-4) that complicate vaccine development due to low-affinity, cross-reactive antibodies that increase the risk of antibody-dependent enhancement (ADE ...
Dominik A. Rothen, Alessandro Pardini, Sudip Kumar Dutta, Pascal S. Krenger, Anne-Cathrine Vogt, Romano Josi, Monique Vogel, Paul Engeroff, Mona O. Mohsen, Kaspars Tars, Byron Martina, Martin F. Bachmann   +11 more
doaj   +1 more source

Dengue Virus Molecular Targets and Antiviral Drug Development: Advances, Challenges and Therapeutic Perspectives

ChemistrySelect, Volume 11, Issue 33, 1 September 2026.
This narrative review analyzes DENV molecular targets, including structural proteins (C, prM/M, E), non‐structural components (NS1NS5), and host factors, alongside small‐molecule candidates in preclinical and clinical phases. Owing to high structural conservation, the NS2B‐NS3 protease and NS5 (RdRp/MTase) remain primary drug discovery focuses, while ...
Aryane Lucia da Silva Aguiar De Oliveira, José Arion Da Silva Moura, Pedro César de Souza, Marcelo Arthur Dias da Costa Santana, Matheus Vinicius Guimarães de Melo, Douglas Carvalho Francisco Viana, Marina Galdino Da Rocha Pitta, Isabella Luiza Ralph de Oliveira, Maira Galdino Da Rocha Pitta   +8 more
wiley   +1 more source

Type I and III interferon responses restrict infection by tick-borne orthoflaviviruses through IFI6

Journal of Virology
Tick-borne orthoflaviviruses (TBOVs) are a growing global health concern. Several members of this viral group cause fatal disease in humans with increasing case numbers throughout the last few decades.
Felix Streicher, Devin Kenney, Vincent Caval, Maxime Chazal, Sophie-Marie Aicher, Ségolène Gracias, Scott Adams, Mao Matsuo, Ferdinand Roesch, Florian Douam, Nolwenn Jouvenet   +10 more
doaj   +1 more source

Design and Synthesis of a Potent, Cell Active Purine‐Based Amidoxime Against the Dengue Virus

ChemistrySelect, Volume 11, Issue 36, 22 September 2026.
Scaffold hopping from our previous indolazepinone hit exemplifies purine SP‐835G with DENV2 EC50 0.1 µM, CC50>100 µM, clogP 3.61. Docking studies support its amidine metabolite operates as an allosteric inhibitor of DENV(pro). A flexible ether linker appears pivotal for enhancing binding and activity.
Dimitrios Kiousis, Despoina Giannioti, Georgia Kalyva, Vasiliki Zogali, Maharah Binte Abdul Mahid, Kitti Wing Ki Chan, Minos‐Timotheos Matsoukas, Subhash G. Vasudevan, Gerasimos Rassias   +8 more
wiley   +1 more source