Results 61 to 70 of about 33,545 (217)

ProTides for Antiviral Activity Beyond Liver Cells

Chemistry – A European Journal, EarlyView.
A strategy for obtaining prodrugs of antiviral nucleotides with broad tissue activity is presented that relies on cycloalkyl or cycloalkylalkyl esters, improving uptake and esterase cleavage, and producing nanomolar inhibitors in kidney, colon, and lung cells.
Felix Goebel, Adrian Humboldt, Heeyoung Kim, Carl J. M. Schölzel, Ralf Bartenschlager, Clemens Richert   +5 more
wiley   +1 more source

Does a decision support tool designed to depict West Nile virus risk explain variation in ruffed grouse Bonasa umbellus use of managed forests?

Wildlife Biology, EarlyView.
Infectious diseases are commonly cited as significant contributors to wildlife population declines. It is, therefore, important to investigate the extent to which tools designed to mitigate the effects of infectious diseases explain wildlife responses to habitat management.
Jacob Goldman, Darin J. McNeil, Lauren M. Chronister, Randall Koleck, Samuel Lapp, Jeffery T. Larkin, Reina Tyl, Justin Kitzes, Jeffery L. Larkin   +8 more
wiley   +1 more source

Membrane curvature in flaviviruses [PDF]

Journal of Structural Biology, 2013
Coordinated interplay between membrane proteins and the lipid bilayer is required for such processes as transporter function and the entrance of enveloped viruses into host cells. In this study, three-dimensional cryo-electron microscopy density maps of mature and immature flaviviruses were analyzed to assess the curvature of the membrane leaflets and ...
Wei, Zhang, Bärbel, Kaufmann, Paul R, Chipman, Richard J, Kuhn, Michael G, Rossmann   +4 more
openaire   +2 more sources

West Nile Virus Infections in (European) Birds [PDF]

, 2016
West Nile virus (WNV), a member of the Flaviviridae family is an important emerging pathogen transmitted by mosquitoes of the Culex sp . wild-and (peri) domesticated birds act as the natural hosts of WNV.
Barzon, Luisa, Koraka, Penelope, Martina, Byron EE   +2 more
core   +1 more source

Tick‐Borne Encephalitis (TBE) Vaccine in the National Immunisation Programme—For Whom, When and Where?

Acta Paediatrica, EarlyView.
ABSTRACT The incidence of Tick‐borne encephalitis (TBE) cases has increased. The presumed location of transmission of Tick‐borne encephalitis virus (TBEV) has been expanding increasingly in the western parts of Europe during the past decade. There has also been an increased incidence of surveillance‐reported TBE cases in southern Sweden and southern ...
H. H. Askling, D. Zavadska
wiley   +1 more source

Deconvolution of pro- and antiviral genomic responses in Zika virus-infected and bystander macrophages. [PDF]

, 2018
Genome-wide investigations of host-pathogen interactions are often limited by analyses of mixed populations of infected and uninfected cells, which lower sensitivity and accuracy.
Benner, Christopher, Branche, Emilie, Carlin, Aaron F, Glass, Christopher K, Heinz, Sven, Ley, Klaus, Shresta, Sujan, Suarez-Amaran, Lester, Viramontes, Karla M, Vizcarra, Edward A   +9 more
core  

Vectors and Vector‐Borne Diseases: Biology, Epidemiology and Integrated Control Strategies

Journal of Applied Entomology, EarlyView.
ABSTRACT Vector‐Borne Diseases (VBDs), transmitted by arthropods such as mosquitoes, ticks, fleas and sandflies, represent a significant threat to global health. These diseases can be caused by a variety of pathogens, including bacteria, viruses, protozoa, and helminths.
Roberta Rinaldi, Carmen Scieuzo, Federica De Stefano, Luca Masucci, Patrizia Falabella   +4 more
wiley   +1 more source

Comparative analysis of the taxonomic classification criteria for a number of groups of pathogenic DNA and RNA viruses based on genomic data

Вопросы вирусологии
The basis for criteria of the taxonomic classification of DNA and RNA viruses based on data of the genomic sequencing are viewed in this review. The genomic sequences of viruses, which have genome represented by double-stranded DNA (orthopoxviruses as ...
Tatiana E. Sizikova, Vitaliy N. Lebedev, Sergey V. Borisevich   +2 more
doaj   +1 more source

Unravelling the biochemical aspects of the interaction between ticks and Leishmania using a tick cell line

Medical and Veterinary Entomology, EarlyView.
Leishmania infantum propagated in IDE8 tick cell line in vitro. L. infantum reduces tick cell viability and induces reactive oxygen species production. Lipidic profile of IDE8 tick cell line is altered during Leishmania infection. Abstract Leishmaniasis comprises a group of vector‐borne neglected tropical diseases caused by species of the obligatory ...
Beatriz Filgueiras Silvestre, Karoline dos Anjos Lima, Fernanda de Paula Pepino, Daniela Cosentino‐Gomes, Adivaldo Fonseca, Lesley Bell‐Sakyi, Georgia Correa Atella, Lucia H. Pinto‐da‐Silva   +7 more
wiley   +1 more source

Zika virus infection in semen: Effect on human reproduction [PDF]

, 2017
Unique among vector-borne flaviviruses, Zika virus can infect testis and male genital tract, can persist in semen for months after symptoms onset, and be sexually transmitted.
Barzon, Luisa, Lavezzo, Enrico, Pal\ue3\ub9, Giorgio   +2 more
core   +1 more source