Results 51 to 60 of about 33,545 (217)

Palmitic Acid Promotes Antiviral Innate Immunity via ZDHHC20‐Mediated CMPK2 Palmitoylation

Advanced Science, EarlyView.
Metabolites have important functions in innate immune activation and regulation. Wang et al. uncover metabolic regulation of antiviral immunity through CMPK2 palmitoylation, which regulates CMPK2 mitochondrial localization and is promoted by ZDHHC20 but reversed by PPT1, inhibition of which antagonizes viral infection in mice.
Yujia Wang, Zenghui Cui, Yunkai Zhang, Zhiqing Li, Xuetao Cao   +4 more
wiley   +1 more source

Mono-WNV and combined WNV/TBEV inactivated vaccine efficacy against a wide range of WNV and TBEV strains

Frontiers in Immunology
West Nile virus (WNV) is widespread throughout the world. Occasionally, it causes outbreaks of the West Nile fever (WNF) disease, which can lead to severe CNS damage or death.
Ksenia Tuchynskaya, Mikhail Vorovitch, Mikhail Vorovitch, Yuriy Kruglov, Guzal Mostipanova, Ivan Kholodilov, Alla Ivanova, Victoria Kuchina, Anastasia Rogova, Galina Karganova, Galina Karganova   +10 more
doaj   +1 more source

Microbial Odorant Detection Guides Drosophila Parasitoids Seeking Hosts in Fermenting Fruits

Advanced Science, EarlyView.
Yeast microbes in fermenting fruits attract both host flies and their parasitoid wasps. Female Leptopilina boulardi detect yeast‐emitted ethyl esters via two olfactory receptors, LbouOR167 and LbouOR136. A conserved residue, Leu159, is critical for binding these compounds, enabling female wasps to locate host‐rich habitats.
Yueqi Lu, Lan Pang, Wenqi Shi, Ting Feng, Zhi Dong, Yifeng Sheng, Sicong Zhou, Longtao Yu, Hao Guo, Ying Wang, Jiani Chen, Jianhua Huang   +11 more
wiley   +1 more source

Potential Role of Flavivirus NS2B-NS3 Proteases in Viral Pathogenesis and Anti-flavivirus Drug Discovery Employing Animal Cells and Models: A Review

Viruses, 2021
Flaviviruses are known to cause a variety of diseases in humans in different parts of the world. There are very limited numbers of antivirals to combat flavivirus infection, and therefore new drug targets must be explored.
Abdul Wahaab, Bahar E Mustafa, Muddassar Hameed, Nigel J. Stevenson, Muhammad Naveed Anwar, Ke Liu, Jianchao Wei, Yafeng Qiu, Zhiyong Ma   +8 more
doaj   +1 more source

Functional Information Stored in the Conserved Structural RNA Domains of Flavivirus Genomes [PDF]

, 2017
The genus Flavivirus comprises a large number of small, positive-sense single-stranded, RNA viruses able to replicate in the cytoplasm of certain arthropod and/or vertebrate host cells.
Berzal-Herranz, Alfredo, Fernández-Sanlés, Alba, Romero-López, Cristina, Ríos-Marco, Pablo   +3 more
core   +1 more source

Secreted Nonstructural Protein 3 is a Pathogenic Determinant of Orbivirus

Advanced Science, EarlyView.
This study uncovers a conserved PIP2‐dependent secretory pathway of orbivirus NS3 that induces vascular leakage. Pharmacological disruption of PIP2‐NS3 interaction significantly reduces viral pathogenicity and provides protective efficacy in murine models, establishing PIP2‐mediated NS3 secretion as both a key virulence determinant and a promising ...
Junyong Guan, Dong Zhou, Ran Shao, Xing Liu, Jin Peng, Yingran Huang, Shuhui Qi, Cankun Xi, Menghang Wang, Bin Sun, Yinglin Qi, Xin Yin   +11 more
wiley   +1 more source

Membranous Replication Factories Induced by Plus-Strand RNA Viruses

Viruses, 2014
In this review, we summarize the current knowledge about the membranous replication factories of members of plus-strand (+) RNA viruses. We discuss primarily the architecture of these complex membrane rearrangements, because this topic emerged in the ...
Inés Romero-Brey, Ralf Bartenschlager
doaj   +1 more source

Rational Design of Broad‐Spectrum Anti‐Enteroviral Molecular Glues Targeting Enteroviral RNAi Suppressors

Advanced Science, EarlyView.
By leveraging this homodimerization mechanism, molecular glues were rationally designed to induce dysfunctional 3A dimerization, thereby restoring antiviral RNAi. The optimal molecular glue, VTP‐32, demonstrated potent and pan‐enterovirus (groups A, B, D) antiviral effects.
Yuan Fang, Xiong Xie, Huidi Fan, Botao Wu, An Wang, Wenhao Dai, Zezhong Liu, Jian Li, Huoyan Tong, Jianan Li, Yujie Ren, Jinlin Wang, Xi Zhou, Hong Liu   +13 more
wiley   +1 more source

Flaviviruses in AntiTumor Therapy

Viruses, 2023
Oncolytic viruses offer a promising approach to tumor treatment. These viruses not only have a direct lytic effect on tumor cells but can also modify the tumor microenvironment and activate antitumor immunity. Due to their high pathogenicity, flaviviruses have often been overlooked as potential antitumor agents.
Alina S. Nazarenko, Mikhail F. Vorovitch, Yulia K. Biryukova, Nikolay B. Pestov, Ekaterina A. Orlova, Nickolai A. Barlev, Nadezhda M. Kolyasnikova, Aydar A. Ishmukhametov   +7 more
openaire   +3 more sources

Ecuador Paraiso Escondido virus, a new flavivirus isolated from New World sand flies in Ecuador, is the first representative of a novel clade in the genus flavivirus [PDF]

, 2015
A new flavivirus, Ecuador Paraiso Escondido virus (EPEV), named after the village where it was discovered, was isolated from sand flies (Psathyromyia abonnenci, formerly Lutzomyia abonnenci) that are unique to the New World.
Alkan, Cigdem, Bichaud, Laurence, Charrel, Rémi N., de Lamballerie, Xavier, Depaquit, Jérôme, Firth, Andrew E., Gould, Ernest A., Gritsun, Tamara S., Lemey, Philippe, Moureau, Grégory, Zapata, Sonia   +10 more
core   +3 more sources