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Zika Virus Vaccines: Challenges and Perspectives
Vaccines, 2018 Zika virus is an arbovirus that has rapidly spread within the Americas since 2014, presenting a variety of clinical manifestations and neurological complications resulting in congenital malformation, microcephaly, and possibly, in male infertility. These
Raquel das Neves Almeida +3 more
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Development of genus-specific universal primers for the detection of flaviviruses
Virology Journal, 2021 Background Flaviviruses are representative arboviruses carried by arthropods and/or vertebrates; these viruses can pose a public health concern in many countries. By contrast, it is known that a novel virus group called insect-specific flaviviruses (ISFs)
Tomo Daidoji +9 more
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Flaviviruses: braking the entering [PDF]
Current Opinion in Virology, 2013 Flaviviruses are small spherical virus particles covered by a dense icosahedral array of envelope (E) proteins that mediate virus attachment to cells and the fusion of viral and cellular membranes. Our understanding of the mechanism by which flavivirus E proteins orchestrate entry into cells has been advanced by studies of E structure and arrangement ...
Theodore C, Pierson, Margaret, Kielian
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The MicrobeFlaviviruses are enveloped, single-stranded RNA viruses that are largely arthropod-borne, circulating globally and infecting up to 400 million people annually.
Abdulbariu Ogirima Uhuami +3 more
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Frontiers in Microbiology, 2018 Flaviviruses are arboviruses, which comprises more than 70 viruses, covering broad geographic ranges, and responsible for significant mortality and morbidity globally. Due to the lack of efficient inhibitors targeting flaviviruses, the designing of novel
Akanksha Rajput, Manoj Kumar
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Presence of Segmented Flaviviruses in Wild Rodents, Pennsylvania, USA
Emerging Infectious Diseases, 2020 Identifying viruses in synanthropic animals is necessary for understanding the origin of many viruses that can infect human hosts and developing strategies to prevent new zoonotic infections.
Arvind Kumar +7 more
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Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection
Emerging Infectious Diseases, 2017 Cross-reactive antibodies elicited by dengue virus (DENV) infection might affect Zika virus infection and confound serologic tests. Recent data demonstrate neutralization of Zika virus by monoclonal antibodies or human serum collected early after DENV ...
Matthew H. Collins +7 more
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Advanced Science, EarlyView.This study reports D34 as the first PROTAC degrader that targets the 3C protease of picornaviruses. D34 effectively degrades EV71 3C protease via the ubiquitin‐proteasome pathway. More importantly, D34 exhibits a high resistance barrier and shows broad‐spectrum antiviral activity against multiple picornaviruses, highlighting its potential as a novel ...
Weilong Deng +9 more
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Flaviviruses – new human pathogens
, 2018 The family Flaviviridae includes arthropod-borne viruses that are transmitted to vertebrates by infected mosquitoes and ticks. There are over a 100 species in this family, most of which are animal pathogens, although it cannot be excluded that some ...
Małgorzata Inglot +3 more
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Mosquito-Borne Flaviviruses and Current Therapeutic Advances
, 2022 Mosquito-borne flavivirus infections affect approximately 400 million people worldwide each year and are global threats to public health. The common diseases caused by such flaviviruses include West Nile, yellow fever, dengue, Zika infection and Japanese
Qi, Zhongtian +3 more
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