Results 41 to 50 of about 26,784 (178)

Anti-flavi: A Web Platform to Predict Inhibitors of Flaviviruses Using QSAR and Peptidomimetic Approaches

Frontiers in Microbiology, 2018
Flaviviruses are arboviruses, which comprises more than 70 viruses, covering broad geographic ranges, and responsible for significant mortality and morbidity globally. Due to the lack of efficient inhibitors targeting flaviviruses, the designing of novel
Akanksha Rajput, Manoj Kumar
doaj   +1 more source

Presence of Segmented Flaviviruses in Wild Rodents, Pennsylvania, USA

Emerging Infectious Diseases, 2020
Identifying viruses in synanthropic animals is necessary for understanding the origin of many viruses that can infect human hosts and developing strategies to prevent new zoonotic infections.
Arvind Kumar, Kurt J. Vandegrift, Himanshu Sharma, Satyapramod Murthy, Laura D. Kramer, Richard Ostfeld, Peter Hudson, Amit Kapoor   +7 more
doaj   +1 more source

Lack of Durable Cross-Neutralizing Antibodies Against Zika Virus from Dengue Virus Infection

Emerging Infectious Diseases, 2017
Cross-reactive antibodies elicited by dengue virus (DENV) infection might affect Zika virus infection and confound serologic tests. Recent data demonstrate neutralization of Zika virus by monoclonal antibodies or human serum collected early after DENV ...
Matthew H. Collins, Eileen McGowan, Ramesh Jadi, Ellen Young, Cesar A. Lopez, Ralph S. Baric, Helen M. Lazear, Aravinda M. de Silva   +7 more
doaj   +1 more source

Conserved dimerization architecture in C‐type lectins from virus‐vector mosquitoes

The FEBS Journal, EarlyView.
C‐type lectins (CTLs) are involved in the detection of viral/microbial carbohydrates. We studied a family of soluble CTLs in the mosquito Aedes aegypti, which acts as a vector for viruses like dengue and Zika. Using crystallography, biophysics, and structure prediction approaches, we found that these proteins consistently pair together in the same ...
Mattia Bertinelli, Rupesh Balaji Jayachandran, Jack Whitehead, Cédric Leyrat, Annabel v. Clanner, Guido C Paesen, Max Renner   +6 more
wiley   +1 more source

Flaviviruses of public health concern in South Africa: Present and future threats

Southern African Journal of Infectious Diseases
Background: The resurgence and widespread transmission of flaviviruses over the past few decades are particularly concerning. Aim: This review discusses the structure, aetiology, transmission, detection, diagnosis and prevention strategies for ...
Angela Sibanda-Makuvise, Abigarl Ndudzo, Felicity J. Burt   +2 more
doaj   +1 more source

The thermal stability of yellow fever vaccines

Memorias do Instituto Oswaldo Cruz, 1990
The assessment of yellow fever vaccine thermostability both in lyophilized form and after reconstitution were analyzed. Two commercial yellow fever vaccines were assayed for their thermal stability. Vaccines were exposed to test temperatures in the range
Ricardo Ishak, Colin R. Howard
doaj   +1 more source

Advances in Cytosolic dsRNA Sensing of Viral Infections

Immunology &Cell Biology, EarlyView.
Activation of cytosolic dsRNA sensors by viral infection generates multiple outcomes. dsRNA generated during viral infection, either of viral origin or from endogenous sources, can activate multiple cytosolic dsRNA sensors. Activation of PKR critically induces protein translation shutdown via phosphorylation of eukaryotic translation initiation factor ...
Sofia Maceratessi, Natalia G. Sampaio
wiley   +1 more source

Biochemistry and molecular biology of flaviviruses

, 2018
Flaviviruses, such as dengue, Japanese encephalitis, tick-borne encephalitis, West Nile, yellow fever, and Zika viruses, are critically important human pathogens that sicken a staggeringly high number of humans every year.
Campos, Rafael, Barrows, N. J., Geraldine Schott-Lerner, Sessions, October, M, Soto-Acosta, R., Shih-Chia Yeh, Soto-Acosta, Ruben, Prasanth, K. R., Ruben Soto-Acosta, Shelton S. Bradrick, Liao, K. C., Garcia-Blanco, Mariano, Pompon, Julien, Julien Pompon, Liao, Kuo-Chieh, Yeh, Shih-Chia, Campos, R. K., Rafael K. Campos, Schott-Lerner, G., Mariano A. Garcia-Blanco, Schott-Lerner, Geraldine, O, Bradrick, S. S., Kuo-Chieh Liao, Prasanth, K. Reddisiva, Sessions, O. M., Barrows, Nicholas, K. Reddisiva Prasanth, Yeh, S. C., Bradrick, Shelton, Nicholas J. Barrows, October M. Sessions, Garcia-Blanco, M. A.   +31 more
core   +1 more source

Predicting wildlife reservoirs and global vulnerability to zoonotic Flaviviruses [PDF]

, 2018
Flaviviruses continue to cause globally relevant epidemics and have emerged or re-emerged in regions that were previously unaffected. Factors determining emergence of flaviviruses and continuing circulation in sylvatic cycles are incompletely understood.
Smart, Katrina M, Drape, Gaylen W, Pandit, Pranav S, Johnson, Christine K, Doyle, Megan M, Young, Cristin CW   +5 more
core   +1 more source

Adenovirus vector-based vaccines as forefront approaches in fighting the battle against flaviviruses

, 2022
Flaviviruses are arthropod-borne viruses (arboviruses) that have been recently considered among the significant public health problems in defined geographical regions. In this line, there have been vaccines approved for some flaviviruses including dengue
Arashkia, Arash, Hasan Bakhshi, Roohvand, Farzin, Mostafa Salehi-Vaziri, Salehi-Vaziri, Mostafa, Farzin Roohvand, Kayhan Azadmanesh, Shoushtari, Mohammad, Mohammad Shoushtari, Arash Arashkia, Bakhshi, Hasan, Azadmanesh, Kayhan   +11 more
core   +1 more source