Inhibition of type I interferon induction and signalling by mosquito-borne flaviviruses [PDF]
, 2017 The Flavivirus genus (Flaviviridae family) contains a number of important human pathogens, including dengue and Zika viruses, which have the potential to cause severe disease.
Clark, Jordan J. +3 more
core +1 more source
A 212-nt long RNA structure in the Tobacco necrosis virus-D RNA genome is resistant to Xrn degradation [PDF]
, 2019 Plus-strand RNA viruses can accumulate viral RNA degradation products during infections. Some of these decay intermediates are generated by the cytosolic 5′-to-3′ exoribonuclease Xrn1 (mammals and yeast) or Xrn4 (plants) and are formed when the enzyme ...
Chaminda, Gunawardene D. +2 more
core +1 more source
Zika virus infection reprograms global transcription of host cells to allow sustained infection. [PDF]
, 2017 Zika virus (ZIKV) is an emerging virus causally linked to neurological disorders, including congenital microcephaly and Guillain-Barré syndrome. There are currently no targeted therapies for ZIKV infection.
Bansal, Vikas +5 more
core +2 more sources
The Dual Regulation of Apoptosis by Flavivirus
Frontiers in Microbiology, 2021 Apoptosis is a form of programmed cell death, which maintains cellular homeostasis by eliminating pathogen-infected cells. It contains three signaling pathways: death receptor pathway, mitochondria-mediated pathway, and endoplasmic reticulum pathway. Its
Yuhong Pan +12 more
doaj +1 more source
Human case of West Nile neuroinvasive disease in Portugal, summer 2015 [PDF]
, 2015 A case of West Nile virus (WNV) infection was reported in the Algarve region, Portugal, in the first week of September 2015. WNV is known to circulate in Portugal, with occasional reports in horses and birds (2004 to 2011) and very sporadically human ...
Alves, M. J. +7 more
core +1 more source
Predicting wildlife reservoirs and global vulnerability to zoonotic Flaviviruses. [PDF]
, 2018 Flaviviruses continue to cause globally relevant epidemics and have emerged or re-emerged in regions that were previously unaffected. Factors determining emergence of flaviviruses and continuing circulation in sylvatic cycles are incompletely understood.
Doyle, Megan M +5 more
core +2 more sources
Lipid Interactions Between Flaviviruses and Mosquito Vectors
Frontiers in Physiology, 2021 Mosquito-borne flaviviruses, such as dengue (DENV), Zika (ZIKV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis (JEV) viruses, threaten a large part of the human populations.
Thomas Vial +5 more
doaj +1 more source
Differentiation enhances Zika virus infection of neuronal brain cells. [PDF]
, 2018 Zika virus (ZIKV) is an emerging, mosquito-borne pathogen associated with a widespread 2015-2016 epidemic in the Western Hemisphere and a proven cause of microcephaly and other fetal brain defects in infants born to infected mothers. ZIKV infections have
Bouquet, Jerome +6 more
core +3 more sources
mRNA Vaccines against Flaviviruses [PDF]
Vaccines, 2021 Numerous vaccines have now been developed using the mRNA platform. In this approach, mRNA coding for a viral antigen is in vitro synthesized and injected into the host leading to exogenous protein expression and robust immune responses. Vaccines can be rapidly developed utilizing the mRNA platform in the face of emerging pandemics.
Clayton J. Wollner, Justin M. Richner
openaire +3 more sources
Zika virus infection in the returning traveller: what every neurologist should know [PDF]
, 2018 Zika virus has been associated with a wide range of neurological complications. Neurologists in areas without current active transmission of the virus may be confronted with Zika-associated neurological disease, as a large number of returning travellers ...
Brito Ferreira, Maria Lucia +6 more
core +6 more sources