Results 21 to 30 of about 26,784 (178)

mRNA Vaccines against Flaviviruses

, 2021
Numerous vaccines have now been developed using the mRNA platform. In this approach, mRNA coding for a viral antigen is in vitro synthesized and injected into the host leading to exogenous protein expression and robust immune responses.
Clayton J. Wollner, Justin M. Richner
core   +1 more source

Vector-Transmitted Flaviviruses: An Antiviral Molecules Overview [PDF]

, 2023
: Flaviviruses cause numerous pathologies in humans across a broad clinical spectrum with potentially severe clinical manifestations, including hemorrhagic and neurological disorders.
Lotti, Virginia, Cecchetto, Riccardo, Tonon, Emil, Erica Diani, Virginia Lotti, Emil Tonon, Lagni, Anna, Riccardo Cecchetto, Diani, Erica, Gibellini, Davide, Davide Gibellini, Anna Lagni   +11 more
core   +1 more source

Nucleic Acid Preservation Card Surveillance Is Effective for Monitoring Arbovirus Transmission on Crocodile Farms and Provides a One Health Benefit to Northern Australia

Viruses, 2022
The Kunjin strain of West Nile virus (WNVKUN) is a mosquito-transmitted flavivirus that can infect farmed saltwater crocodiles in Australia and cause skin lesions that devalue the hides of harvested animals.
Nina Kurucz, Jamie Lee McMahon, Allan Warchot, Glen Hewitson, Jean Barcelon, Frederick Moore, Jasmin Moran, Jessica J. Harrison, Agathe M. G. Colmant, Kyran M. Staunton, Scott A. Ritchie, Michael Townsend, Dagmar Meyer Steiger, Roy A. Hall, Sally R. Isberg, Sonja Hall-Mendelin   +15 more
doaj   +1 more source

Application of DNA Replicons in Gene Therapy and Vaccine Development

Pharmaceutics, 2023
DNA-based gene therapy and vaccine development has received plenty of attention lately. DNA replicons based on self-replicating RNA viruses such as alphaviruses and flaviviruses have been of particular interest due to the amplification of RNA transcripts
Kenneth Lundstrom
doaj   +1 more source

Tetraspanins as Potential Therapeutic Candidates for Targeting Flaviviruses

Frontiers in Immunology, 2021
Tetraspanin family of proteins participates in numerous fundamental signaling pathways involved in viral transmission, virus-specific immunity, and virus-mediated vesicular trafficking.
Waqas Ahmed, Girish Neelakanta, Girish Neelakanta, Hameeda Sultana, Hameeda Sultana   +4 more
doaj   +1 more source

Flaviviruses: Innate Immunity, Inflammasome Activation, Inflammatory Cell Death, and Cytokines

Frontiers in Immunology, 2022
The innate immune system is the host’s first line of defense against the invasion of pathogens including flavivirus. The programmed cell death controlled by genes plays an irreplaceable role in resisting pathogen invasion and preventing pathogen ...
Yuhong Pan, Yuhong Pan, Yuhong Pan, Wenjun Cai, Wenjun Cai, Wenjun Cai, Anchun Cheng, Anchun Cheng, Anchun Cheng, Mingshu Wang, Mingshu Wang, Mingshu Wang, Zhongqiong Yin, Renyong Jia, Renyong Jia, Renyong Jia   +15 more
doaj   +1 more source

A Review of Flaviviruses that Have No Known Arthropod Vector [PDF]

, 2017
Most viruses in the genus Flavivirus are horizontally transmitted between hematophagous arthropods and vertebrate hosts, but some are maintained in arthropod- or vertebrate-restricted transmission cycles.
Andrew Firth, Bradley Blitvich
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Monocyte-Derived Dendritic Cells as Model to Evaluate Species Tropism of Mosquito-Borne Flaviviruses. [PDF]

, 2019
Several mosquito-borne Flaviviruses such as Japanese encephalitis virus (JEV), West Nile virus (WNV), Dengue Virus (DENV), and Zika virus (ZIKV) can cause severe clinical disease.
Lewandowska, Marta, Summerfield, Artur, Garcia Nicolas, Obdulio, Ricklin, Meret E.   +3 more
core   +4 more sources

Molecular evolution of the insect-specific flaviviruses [PDF]

, 2012
There has been an explosion in the discovery of ‘insect-specific’ flaviviruses and/or their related sequences in natural mosquito populations. Herein we review all ‘insect-specific’ flavivirus sequences currently available and conduct phylogenetic ...
Andrew Kitchen, Moureau, Gregory, Gould, E. A., Gould, Ernest A., Ralph E. Harbach, de Lamballerie, Xavier, Holmes, Edward C., Holmes, E. C., Shelley Cook, Harbachl, R. E., Edward C. Holmes, Cook, S., Ernest A. Gould, Xavier de Lamballerie, Gregory Moureau, Kitchen, Andrew, Cook, Shelley, Harbach, Ralph E., Kitchen, A.   +18 more
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Flaviviruses in AntiTumor Therapy

, 2023
Oncolytic viruses offer a promising approach to tumor treatment. These viruses not only have a direct lytic effect on tumor cells but can also modify the tumor microenvironment and activate antitumor immunity.
Yulia K. Biryukova, Nadezhda M. Kolyasnikova, Ekaterina A. Orlova, Nickolai A. Barlev, Aydar A. Ishmukhametov, Alina S. Nazarenko, Mikhail F. Vorovitch, Nikolay B. Pestov   +7 more
core   +1 more source