Results 51 to 60 of about 11,677 (208)

Mechanisms of flavoprotein‐catalyzed reactions [PDF]

European Journal of Biochemistry, 1989
Flavoproteins are a class of enzymes catalyzing a very broad spectrum of redox processes by different chemical mechanisms. This review describes the best studied of these mechanisms and discusses factors possibly governing reactivity and specificity.
Ghisla, Sandro, Massey, Vincent
openaire   +5 more sources

Mechanism and substrate specificity of the flavin reductase ActVB from Streptomyces coelicolor. [PDF]

, 2003
International audienceActVB is the NADH:flavin oxidoreductase participating in the last step of actinorhodin synthesis in Streptomyces coelicolor. It is the prototype of a whole class of flavin reductases with both sequence and functional similarities ...
Filisetti, Laurent, Fontecave, Marc, Niviere, Vincent   +2 more
core   +3 more sources

Engineering an Artificial Flavoprotein Magnetosensor [PDF]

Journal of the American Chemical Society, 2016
Migratory birds use the Earth's magnetic field as a source of navigational information. This light-dependent magnetic compass is thought to be mediated by cryptochrome proteins in the retina. Upon light activation, electron transfer between the flavin adenine dinucleotide cofactor and tryptophan residues leads to the formation of a spin-correlated ...
Chris Bialas, Lauren E. Jarocha, Kevin B. Henbest, Tilo M. Zollitsch, Goutham Kodali, Christiane R. Timmel, Stuart R. Mackenzie, P. Leslie Dutton, Christopher C. Moser, P. J. Hore   +9 more
openaire   +2 more sources

Adaptive Laboratory Evolution of Flavin Functionality Identifies Dihydrolipoyl Dehydrogenase as One of the Critical Points for the Activity of 7,8-Didemethyl-Riboflavin as a Surrogate for Riboflavin in Escherichia coli

Molecules
Riboflavin analogs lacking one methyl group (7α or 8α) can still serve as a surrogate for riboflavin in riboflavin-deficient microorganisms or animals. The absence of both methyl groups at once completely abolishes this substitution capability.
Farshad La-Rostami, Alexandra Scharf, Chenyang Albert, Nils Wax, Marina Creydt, Boris Illarionov, Adelbert Bacher, Stefan Weber, Markus Fischer   +8 more
doaj   +1 more source

Femtosecond dynamics of flavoproteins: Charge separation and recombination in riboflavine (vitamin B_2)-binding protein and in glucose oxidase enzyme [PDF]

, 2001
Flavoproteins can function as hydrophobic sites for vitamin B_2 (riboflavin) or, in other structures, with cofactors for catalytic reactions such as glucose oxidation.
Zewail, Ahmed H., Zhong, Dongping
core  

The phasor-FLIM fingerprints reveal shifts from OXPHOS to enhanced glycolysis in Huntington Disease. [PDF]

, 2016
Huntington disease (HD) is an autosomal neurodegenerative disorder caused by the expansion of Polyglutamine (polyQ) in exon 1 of the Huntingtin protein. Glutamine repeats below 36 are considered normal while repeats above 40 lead to HD.
Digman, Michelle A, Marsh, J Lawrence, Sameni, Sara, Syed, Adeela   +3 more
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Expanding the set of rhodococcal Baeyer–Villiger monooxygenases by high-throughput cloning, expression and substrate screening [PDF]

, 2012
To expand the available set of Baeyer–Villiger monooxygenases (BVMOs), we have created expression constructs for producing 22 Type I BVMOs that are present in the genome of Rhodococcus jostii RHA1.
A Alfieri, A. Riebel, C Szolkowy, D Sheng, DE Torres Pazmiño, DE Torres Pazmiño, DE Torres Pazmiño, E Bloois van, F Hollmann, F Secundo, F Zambianchi, G Gonzalo de, G. de Gonzalo, H. M. Dudek, HM Dudek, I Letunic, JD Stewart, JD Thompson, K Tamura, L. Rychlewski, M Ahmad, M Bocola, M Miyamoto, M Renz, M Seto, M. W. Fraaije, MD Mihovilovic, MD Mihovilovic, MP McLeod, MW Fraaije, MW Fraaije, MW Fraaije, NM Kamerbeek, NM Kamerbeek, NM Kamerbeek, P. Stepniak, R Orru, S Saheki, S Wu   +38 more
core   +4 more sources

Synergistic Tuning of Conformational Dynamics, Electron Tunneling, and Substrate Positioning Enhances Electron Transfer in a P450 Chimera for Calcifediol Biosynthesis

Advanced Science, EarlyView.
A synergistic electron transfer (ET) optimization strategy modulating conformational dynamics, ET pathway, and substrate orientation is proposed for self‐sufficient cytochrome P450s. Guided by this strategy, a P450 variant with improved ET and catalytic efficiency was identified, and the underlying molecular basis was revealed by computational analysis.
Ziqi Liang, Xitong Song, Shuming Cheng, Yiwen Shen, Jie Zhang, Yaru Wang, Huiying Luo, Bin Yao, Binju Wang, Tao Tu   +9 more
wiley   +1 more source

Richard Nelson Perham. 27 April 1937—14 February 2015 [PDF]

, 2018
Richard Nelson Perham, FRS, FMedSci, FRSA, was a British professor of structural biochemistry. He undertook his academic career at the University of Cambridge, holding positions as lecturer, reader, chair and head of the Department of Biochemistry, as ...
Charoy, François, Ferme, Vincenzo, Labba, Chahrazed, On the Move toMeaningful Internet Systems, Pautasso, Cesare, Rosinosky, Guillaume, Youcef, Samir   +6 more
core   +3 more sources