Results 1 to 10 of about 26,547 (202)

Flavoprotein monooxygenases for oxidative biocatalysis: recombinant expression in microbial hosts and applications

Frontiers in Microbiology, 2014
External flavoprotein monooxygenases comprise a group of flavin-dependent oxidoreductases that catalyze the insertion of one atom of molecular oxygen into an organic substrate and the second atom is reduced to water. These enzymes are involved in a great
Romina D. Ceccoli, Dario A. Bianchi, Daniela V. Rial   +2 more
exaly   +3 more sources

Pyridine Nucleotide Coenzyme Specificity of p-Hydroxybenzoate Hydroxylase and Related Flavoprotein Monooxygenases

Frontiers in Microbiology, 2018
p-Hydroxybenzoate hydroxylase (PHBH; EC 1.14.13.2) is a microbial group A flavoprotein monooxygenase that catalyzes the ortho-hydroxylation of 4-hydroxybenzoate to 3,4-dihydroxybenzoate with the stoichiometric consumption of NAD(P)H and oxygen.
Janosch A D Gröning, Dirk Tischler, Willem Van Berkel   +2 more
exaly   +3 more sources

The structural and functional roles of the flavin cofactor FAD in mammalian cryptochromes

Frontiers in Molecular Biosciences, 2023
The importance of circadian rhythms in human health and disease calls for a thorough understanding of the underlying molecular machinery, including its key components, the flavin adenine dinucleotide (FAD)-containing flavoproteins cryptochrome 1 and 2 ...
Giulia Calloni, R. Martin Vabulas
doaj   +1 more source

Yin and Yang in Post-Translational Modifications of Human D-Amino Acid Oxidase

Frontiers in Molecular Biosciences, 2021
In the central nervous system, the flavoprotein D-amino acid oxidase is responsible for catabolizing D-serine, the main endogenous coagonist of N-methyl-D-aspartate receptor.
Silvia Sacchi, Valentina Rabattoni, Matteo Miceli, Loredano Pollegioni   +3 more
doaj   +1 more source

Substrate Inhibition of 5β-Δ4-3-Ketosteroid Dehydrogenase in Sphingobium sp. Strain Chol11 Acts as Circuit Breaker During Growth With Toxic Bile Salts

Frontiers in Microbiology, 2021
In contrast to many steroid hormones and cholesterol, mammalian bile salts are 5β-steroids, which leads to a bent structure of the steroid core. Bile salts are surface-active steroids excreted into the environment in large amounts, where they are subject
Franziska M. Feller, Gina Marke, Steffen L. Drees, Lars Wöhlbrand, Ralf Rabus, Bodo Philipp, Bodo Philipp   +6 more
doaj   +1 more source

Redox-controlled reorganization and flavin strain within the ribonucleotide reductase R2b–NrdI complex monitored by serial femtosecond crystallography

eLife, 2022
Redox reactions are central to biochemistry and are both controlled by and induce protein structural changes. Here, we describe structural rearrangements and crosstalk within the Bacillus cereus ribonucleotide reductase R2b–NrdI complex, a di-metal ...
Juliane John, Oskar Aurelius, Vivek Srinivas, Patricia Saura, In-Sik Kim, Asmit Bhowmick, Philipp S Simon, Medhanjali Dasgupta, Cindy Pham, Sheraz Gul, Kyle D Sutherlin, Pierre Aller, Agata Butryn, Allen M Orville, Mun Hon Cheah, Shigeki Owada, Kensuke Tono, Franklin D Fuller, Alexander Batyuk, Aaron S Brewster, Nicholas K Sauter, Vittal K Yachandra, Junko Yano, Ville RI Kaila, Jan Kern, Hugo Lebrette, Martin Högbom   +26 more
doaj   +1 more source

Structural Determinants of the Specific Activities of an L-Amino Acid Oxidase from Pseudoalteromonas luteoviolacea CPMOR-1 with Broad Substrate Specificity

Molecules, 2022
The Pseudoalteromonas luteoviolacea strain CPMOR-1 expresses a flavin adenine dinucleotide (FAD)-dependent L-amino acid oxidase (LAAO) with broad substrate specificity.
Kyle J. Mamounis, Maria Luiza Caldas Nogueira, Daniela Priscila Marchi Salvador, Andres Andreo-Vidal, Antonio Sanchez-Amat, Victor L. Davidson   +5 more
doaj   +1 more source

Plant Flavoprotein Photoreceptors [PDF]

Plant and Cell Physiology, 2014
Plants depend on the surrounding light environment to direct their growth. Blue light (300-500 nm) in particular acts to promote a wide variety of photomorphogenic responses including seedling establishment, phototropism and circadian clock regulation.
Christie, John M., Blackwood, Lisa, Petersen, Jan, Sullivan, Stuart   +3 more
openaire   +3 more sources

Flavoprotein oxidases: classification and applications [PDF]

Applied Microbiology and Biotechnology, 2013
This review provides an overview of oxidases that utilise a flavin cofactor for catalysis. This class of oxidative flavoenzymes has shown to harbour a large number of biotechnologically interesting enzymes. Applications range from their use as biocatalysts for the synthesis of pharmaceutical compounds to the integration in biosensors.
Dijkman WP, de Gonzalo G, Fraaije MW, MATTEVI, ANDREA   +3 more
openaire   +4 more sources

Fusarium Photoreceptors

Journal of Fungi, 2023
Light is an important modulating signal in fungi. Fusarium species stand out as research models for their phytopathogenic activity and their complex secondary metabolism.
Javier Pardo-Medina, M. Carmen Limón, Javier Avalos   +2 more
doaj   +1 more source