Results 21 to 30 of about 26,547 (202)

CHOP THERAPY INDUCED MITOCHONDRIAL REDOX STATE ALTERATION IN NON-HODGKIN'S LYMPHOMA XENOGRAFTS [PDF]

Journal of Innovative Optical Health Sciences, 2013
We are interested in investigating whether cancer therapy may alter the mitochondrial redox state in cancer cells to inhibit their growth and survival.
H. N. XU, H. ZHAO, T. A. MIR, S. C. LEE, M. FENG, R. CHOE, J. D. GLICKSON, L. Z. LI   +7 more
doaj   +1 more source

A Cysteine Pair Controls Flavin Reduction by Extracellular Cytochromes during Anoxic/Oxic Environmental Transitions

mBio, 2023
Many bacteria of the genus Shewanella are facultative anaerobes able to reduce a broad range of soluble and insoluble substrates, including Fe(III) mineral oxides.
Michael P. Norman, Marcus J. Edwards, Gaye F. White, Joshua A. J. Burton, Julea N. Butt, David J. Richardson, Ricardo O. Louro, Catarina M. Paquete, Thomas A. Clarke   +8 more
doaj   +1 more source

Bacterial Production, Characterization and Protein Modeling of a Novel Monofuctional Isoform of FAD Synthase in Humans: An Emergency Protein?

Molecules, 2018
FAD synthase (FADS, EC 2.7.7.2) is the last essential enzyme involved in the pathway of biosynthesis of Flavin cofactors starting from Riboflavin (Rf). Alternative splicing of the human FLAD1 gene generates different isoforms of the enzyme FAD synthase ...
Piero Leone, Michele Galluccio, Alberto Barbiroli, Ivano Eberini, Maria Tolomeo, Flavia Vrenna, Elisabetta Gianazza, Stefania Iametti, Francesco Bonomi, Cesare Indiveri, Maria Barile   +10 more
doaj   +1 more source

Characterization of succinate dehydrogenase flavoprotein from Staphylococcus aureus ATCC 12600 [PDF]

Journal of Clinical and Scientific Research, 2013
Background: Staphylococcus aureus possesses complete tricarboxylic acid (TCA) cycle. Succinate dehydrogenase (SDH) links TCA cycle with electron transport chain and could therefore be an ideal target in the development of new antimicrobials.
V. Swarupa, S. Yeswanth, U.V. Prasad, D. Vasu, K. Venkatesh, L. Srikanth, P. Anitha, C. Manasa, P.Santhosh Kumar, G. Sowjenya, Y. Nandakumar, Abhijit Chaudhary, P.V.G.K. Sarma   +12 more
doaj  

Allosteric Communication in the Multifunctional and Redox NQO1 Protein Studied by Cavity-Making Mutations

Antioxidants, 2022
Allosterism is a common phenomenon in protein biochemistry that allows rapid regulation of protein stability; dynamics and function. However, the mechanisms by which allosterism occurs (by mutations or post-translational modifications (PTMs)) may be ...
Juan Luis Pacheco-Garcia, Dmitry S. Loginov, Ernesto Anoz-Carbonell, Pavla Vankova, Rogelio Palomino-Morales, Eduardo Salido, Petr Man, Milagros Medina, Athi N. Naganathan, Angel L. Pey   +9 more
doaj   +1 more source

Flavoprotein monooxygenases: Versatile biocatalysts

Biotechnology Advances, 2021
Flavoprotein monooxygenases (FPMOs) are single- or two-component enzymes that catalyze a diverse set of chemo-, regio- and enantioselective oxyfunctionalization reactions. In this review, we describe how FPMOs have evolved from model enzymes in mechanistic flavoprotein research to biotechnologically relevant catalysts that can be applied for the ...
Paul, Caroline E., Eggerichs, Daniel, Westphal, Adrie H., Tischler, Dirk, van Berkel, Willem J.H.   +4 more
openaire   +2 more sources

Functional Impact of the N-terminal Arm of Proline Dehydrogenase from Thermus thermophilus

Molecules, 2018
Proline dehydrogenase (ProDH) is a ubiquitous flavoenzyme that catalyzes the oxidation of proline to Δ1-pyrroline-5-carboxylate. Thermus thermophilus ProDH (TtProDH) contains in addition to its flavin-binding domain an N-terminal arm, consisting of ...
Mieke M. E. Huijbers, Ilona van Alen, Jenny W. Wu, Arjan Barendregt, Albert J. R. Heck, Willem J. H. van Berkel   +5 more
doaj   +1 more source

REDOX IMAGING OF THE p53-DEPENDENT MITOCHONDRIAL REDOX STATE IN COLON CANCER EX VIVO [PDF]

Journal of Innovative Optical Health Sciences, 2013
The mitochondrial redox state and its heterogeneity of colon cancer at tissue level have not been previously reported. Nor has how p53 regulates mitochondrial respiration been measured at (deep) tissue level, presumably due to the unavailability of the ...
HE N. XU, MIN FENG, LILY MOON, NATHAN DOLLOFF, WAFIK EL-DEIRY, LIN Z. LI   +5 more
doaj   +1 more source

Activation of a Flavoprotein by Proteolysis

Journal of Biological Chemistry, 1989
Chymotryptic digestion of brain pyridoxine-5-P oxidase brings about a 4-fold enhancement of the catalytic power (Vmax/KM) using pyridoxine-5-P as substrate in the assay mixtures. The chymotrypsin-treated enzyme is less susceptible to inhibition by pyridoxal-5-P than the native enzyme.
Y T, Kim, J E, Churchich
openaire   +2 more sources

Altered levels of the splicing factor muscleblind modifies cerebral cortical function in mouse models of myotonic dystrophy

Neurobiology of Disease, 2018
Myotonic dystrophy (DM) is a progressive, multisystem disorder affecting skeletal muscle, heart, and central nervous system. In both DM1 and DM2, microsatellite expansions of CUG and CCUG RNA repeats, respectively, accumulate and disrupt functions of ...
Gang Chen, Russell E. Carter, John D. Cleary, Tammy S. Reid, Laura P. Ranum, Maurice S. Swanson, Timothy J. Ebner   +6 more
doaj   +1 more source