Results 31 to 40 of about 26,547 (202)

Engineering an Artificial Flavoprotein Magnetosensor [PDF]

Journal of the American Chemical Society, 2016
Migratory birds use the Earth's magnetic field as a source of navigational information. This light-dependent magnetic compass is thought to be mediated by cryptochrome proteins in the retina. Upon light activation, electron transfer between the flavin adenine dinucleotide cofactor and tryptophan residues leads to the formation of a spin-correlated ...
Chris Bialas, Lauren E. Jarocha, Kevin B. Henbest, Tilo M. Zollitsch, Goutham Kodali, Christiane R. Timmel, Stuart R. Mackenzie, P. Leslie Dutton, Christopher C. Moser, P. J. Hore   +9 more
openaire   +2 more sources

Archaeal LOV domains from Lake Diamante: first functional characterization of a halo-adapted photoreceptor

Frontiers in Microbiology
High-altitude Andean lakes (HAALs) represent polyextreme environments where diverse photoinduced processes have been documented. In this study, we investigated Light-Oxygen-Voltage (LOV) photoreceptors and identified 28 archaeal sequences from Lake ...
Lorena Valle, Lorena Valle, Yonathan J. Coronel, Yonathan J. Coronel, Guillermina E. Bravo, Joaquín A. Díaz, Virginia Helena Albarracín, Virginia Helena Albarracín, María E. Farías, Inés Abatedaga   +9 more
doaj   +1 more source

Distribution in Different Organisms of Amino Acid Oxidases with FAD or a Quinone As Cofactor and Their Role as Antimicrobial Proteins in Marine Bacteria

Marine Drugs, 2015
Amino acid oxidases (AAOs) catalyze the oxidative deamination of amino acids releasing ammonium and hydrogen peroxide. Several kinds of these enzymes have been reported.
Jonatan C. Campillo-Brocal, Patricia Lucas-Elío, Antonio Sanchez-Amat   +2 more
doaj   +1 more source

Assigning function to active site residues of Schistosoma mansoni thioredoxin/glutathione reductase from analysis of transient state reductive half-reactions with variant forms of the enzyme

Frontiers in Molecular Biosciences, 2023
Thioredoxin/glutathione reductase (TGR) from the platyhelminthic parasitic worms has recently been identified as a drug target for the treatment of schistosomiasis.
Madison M. Smith, Graham R. Moran
doaj   +1 more source

VpStyA1/VpStyA2B of Variovorax paradoxus EPS: An Aryl Alkyl Sulfoxidase Rather than a Styrene Epoxidizing Monooxygenase

Molecules, 2018
Herein we describe the first representative of an E2-type two-component styrene monooxygenase of proteobacteria. It comprises a single epoxidase protein (VpStyA1) and a two domain protein (VpStyA2B) harboring an epoxidase (A2) and a FAD-reductase (B ...
Dirk Tischler, Ringo Schwabe, Lucas Siegel, Kristin Joffroy, Stefan R. Kaschabek, Anika Scholtissek, Thomas Heine   +6 more
doaj   +1 more source

KillerRed protein based in vivo photodynamic therapy and corresponding tumor metabolic imaging [PDF]

Journal of Innovative Optical Health Sciences, 2016
Photodynamic therapy (PDT) gains wide attention as a useful therapeutic method for cancer. It is mediated by the oxygen and photosensitizer under the specific light irradiation to produce the reactive oxygen species (ROS), which induce cellular toxicity ...
Qiaoya Lin, Shuang Sha, Fei Yang, Honglin Jin, Zhihong Zhang   +4 more
doaj   +1 more source

Mechanisms of flavoprotein‐catalyzed reactions [PDF]

European Journal of Biochemistry, 1989
Flavoproteins are a class of enzymes catalyzing a very broad spectrum of redox processes by different chemical mechanisms. This review describes the best studied of these mechanisms and discusses factors possibly governing reactivity and specificity.
Ghisla, Sandro, Massey, Vincent
openaire   +5 more sources

A structural decryption of cryptochromes

Frontiers in Chemistry
Cryptochromes (CRYs), which are signaling proteins related to DNA photolyases, play pivotal roles in sensory responses throughout biology, including growth and development, metabolic regulation, circadian rhythm entrainment and geomagnetic field sensing.
Cristina C. DeOliveira, Brian R. Crane
doaj   +1 more source

Establishing an assay to evaluate d‐amino acid oxidase enzyme kinetics and inhibition using WST‐8 redox dye

FEBS Open Bio, EarlyView.
This study investigated a novel WST‐8‐based assay for evaluating d‐Amino acid oxidase (DAO) inhibitors. We confirmed its effectiveness using known inhibitors and found that uremic toxins possess relatively weak inhibitory activity compared to existing drugs.
Kahoko Miyake, Yuki Enoki, Yuka Nakazawa, Kazuaki Taguchi, Kazuaki Matsumoto   +4 more
wiley   +1 more source

A Xylenol Orange-Based Screening Assay for the Substrate Specificity of Flavin-Dependent para-Phenol Oxidases

Molecules, 2018
Vanillyl alcohol oxidase (VAO) and eugenol oxidase (EUGO) are flavin-dependent enzymes that catalyse the oxidation of para-substituted phenols. This makes them potentially interesting biocatalysts for the conversion of lignin-derived aromatic monomers to
Tom A. Ewing, Aster van Noord, Caroline E. Paul, Willem J. H. van Berkel   +3 more
doaj   +1 more source