Results 131 to 140 of about 36,842 (272)

Intracellular Dynamic Disentangling of Doxorubicin Release from Luminescent Nanogold Carriers by Fluorescence Lifetime Imaging Microscopy (FLIM) under Two-Photon Excitation.

ACS Applied Materials and Interfaces, 2019
There is still a lack of available techniques to follow noninvasively the intracellular processes as well to track or disentangle various signals from the therapeutic agents at the site of action in the target cells. We present here the assessment of the
S. Suarasan, A. Craciun, E. Licărete, M. Focșan, K. Magyari, S. Aștilean   +5 more
semanticscholar   +1 more source

PWO proteins are associated with PRC2 since their emergence in vascular plants

New Phytologist, EarlyView.
Summary The Polycomb repressive complex 2 (PRC2), a conserved histone methyltransferase complex, plays a central role in transcriptional silencing across eukaryotes. Here, we investigate the evolution of PWWP‐DOMAIN INTERACTORS OF POLYCOMBS (PWOs), which interact with PRC2, and examine the conservation of the PWOs‐PRC2 interaction across plant ...
Ahamed Khan, Saqlain Haider, Abdoallah Sharaf, Alžbeta Kusová, Jan Skalák, Claire Jourdain, Martin Rennie, Petra Procházková Schrumpfová, Jan Hejátko, Daniel Schubert, Sara Farrona, Iva Mozgová   +11 more
wiley   +1 more source

High-throughput fluorescence lifetime imaging flow cytometry

Nature Communications
Flow cytometry is a vital tool in biomedical research and laboratory medicine. However, its accuracy is often compromised by undesired fluctuations in fluorescence intensity.
Hiroshi Kanno, Kotaro Hiramatsu, Hideharu Mikami, Atsushi Nakayashiki, Shota Yamashita, Arata Nagai, Kohki Okabe, Fan Li, Fei Yin, Keita Tominaga, Omer Faruk Bicer, Ryohei Noma, Bahareh Kiani, Olga Efa, Martin Büscher, Tetsuichi Wazawa, Masahiro Sonoshita, Hirofumi Shintaku, Takeharu Nagai, Sigurd Braun, Jessica P. Houston, Sherif Rashad, Kuniyasu Niizuma, Keisuke Goda   +23 more
doaj   +1 more source

Limits of feedback control in bacterial chemotaxis

, 2014
Inputs to signaling pathways can have complex statistics that depend on the environment and on the behavioral response to previous stimuli. Such behavioral feedback is particularly important in navigation.
Dufour, Yann S., Emonet, Thierry, Fu, Xiongfei, Hernandez-Nunez, Luis   +3 more
core   +3 more sources

Automatic segmentation of intravital fluorescence microscopy images by K-means clustering of FLIM phasors.

Optics Letters, 2019
Fluorescence lifetime imaging microscopy (FLIM) provides additional contrast for fluorophores with overlapping emission spectra. The phasor approach to FLIM greatly reduces the complexity of FLIM analysis and enables a useful image segmentation technique
Yide Zhang, T. Hato, P. Dagher, Evan L. Nichols, Cody J. Smith, K. Dunn, S. Howard   +6 more
semanticscholar   +1 more source

Calcium‐activated chloride channels in pericytes and their role in regulating organ blood flow

The Journal of Physiology, EarlyView.
Abstract figure legend Pericytes are microvascular mural cells with diverse roles. Contractile pericytes directly regulate local perfusion, while non‐contractile pericytes coordinate upstream vascular contractility via propagating electrical signals.
Paolo Tammaro, Hikaru Hashitani
wiley   +1 more source

Unveiling Marketing Competencies for MBA Graduates Through Text Mining and Machine Learning Applications

Applied AI Letters, Volume 7, Issue 2, June 2026.
Industry Driven Competencies for MBA – Marketign Graduates. ABSTRACT In today's dynamic business environment, marketing professionals are expected to demonstrate a balanced mix of conceptual knowledge, technical skills, and behavioral competencies while addressing their customers.
Latha Arumugham, Mohanamani Palanisamy, Maria Tresita Paul Vincent, Md Billal Hossain   +3 more
wiley   +1 more source

Lipid Nanoparticles for the Delivery of CRISPR/Cas9 Machinery to Enable Site‐Specific Integration of CFTR and Mutation‐Agnostic Disease Rescue

Advanced Functional Materials, Volume 36, Issue 36, 4 May 2026.
Lipid nanoparticles (LNPs) are optimized to co‐deliver Cas9‐encoding messenger RNA (mRNA), a single guide RNA (sgRNA) targeting the endogenous cystic fibrosis transmembrane conductance regulator (CFTR) gene, and homologous linear double‐stranded donor DNA (ldsDNA) templates encoding CFTR.
Ruth A. Foley, Paul G. Ayoub, Vrishti Sinha, Colin Juett, Alicia Sanoyca, Emily C. Duggan, Lindsay E. Lathrop, Priyanka Bhatt, Kevin Coote, Beate Illek, Brigitte N. Gomperts, Donald B. Kohn, Steven J. Jonas   +12 more
wiley   +1 more source

Coacervate‐Mediated Lysosome‐Targeting Antibody Delivery for Protein Degradation

Advanced Science, Volume 13, Issue 25, 4 May 2026.
Targeting coacervates to the lysosome in the cytoplasm is a challenge. Here, we convert a tetrapeptide into lysosome‐targeting, membrane‐translocating coacervates. The lysosome‐sorting peptide coacervates facilitate coacervate‐mediated delivery of antibody antigen complexes and a PROTAC compound to the lysosome for the targeted degradation of cancer ...
Dingdong Yuan, Yishu Bao, Zhiyi Xu, Zhong Zheng, Yongxu Han, Kai Cheng, Yuan‐Di Zhao, Jiang Xia   +7 more
wiley   +1 more source

Phase Separation of Parkinson's Disease Protein α‐Synuclein: Mechanistic Insights but Biological Uncertainties

ChemistryEurope, Volume 4, Issue 5, May 2026.
Parkinson's disease‐associated protein α‐synuclein can assemble into liquid condensates under strongly perturbed in vitro and in vivo experimental conditions, including high protein concentration, macromolecular crowding, and when attached to various tags with cross‐linking ability.
Simran Arora, Pernilla Wittung‐Stafshede   +1 more
wiley   +1 more source