Results 151 to 160 of about 1,472,154 (285)

A comprehensive review of flow chemistry techniques tailored to the flavours and fragrances industries. [PDF]

Beilstein J Org Chem, 2021
Gambacorta G, Sharley JS, Baxendale IR.
europepmc   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Improved Two-Dimensional Kinetics (TDK) computer program [PDF]

Fluid properties, the boundary layer module, and regenerative cooling are discussed. Chemistry, low density flow effects, test cases, input and output for TDK, and documentation are also ...
Dang, L. D., Nickerson, G. R.
core   +1 more source

SIRT4 positively regulates autophagy via ULK1, but independently of HDAC6 and OPA1

FEBS Open Bio, EarlyView.
Cells expressing SIRT4 (H161Y), a catalytically inactive mutant of the sirtuin SIRT4, fail to upregulate LC3B‐II and exhibit a reduced autophagic flux under stress conditions. Interestingly, SIRT4(H161Y) promotes phosphorylation of ULK1 at S638 and S758 that are associated with inhibition of autophagy initiation.
Isabell Lehmkuhl, Khawar Amin, Lydia Gabriel, Nils Hampel, Afshin Iram, Julia Hesse, Constanze Wiek, Jasmin Thuy Vy Nguyen, Helmut Hanenberg, Jürgen Scheller, M. Reza Ahmadian, Björn Stork, Doreen M. Floss, Roland P. Piekorz   +13 more
wiley   +1 more source

Investigation of chemically reacting and radiating supersonic internal flows [PDF]

The two-dimensional spatially elliptic Navier-Stokes equations are used to investigate the chemically reacting and radiating supersonic flow of the hydrogen-air system between two parallel plates and in a channel with a ten degree compression-expansion ...
Mani, M., Tiwari, S. N.
core   +1 more source

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Technological Innovations in Photochemistry for Organic Synthesis: Flow Chemistry, High-Throughput Experimentation, Scale-up, and Photoelectrochemistry. [PDF]

Chem Rev, 2022
Buglioni L, Raymenants F, Slattery A, Zondag SDA, Noël T.   +4 more
europepmc   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Advances in Flow Chemistry for Organolithium-Based Synthesis: A Process Perspective. [PDF]

Molecules
Zhou F, Zhou Y, Duanmu C, Li Y, Li J, Xu H, Wang P, Zhu K.   +7 more
europepmc   +1 more source

Accelerating the end-to-end production of cyclic phosphate monomers with modular flow chemistry. [PDF]

Chem Sci, 2022
Morodo R, Riva R, van den Akker NMS, Molin DGM, Jérôme C, Monbaliu JM.   +5 more
europepmc   +1 more source