Results 61 to 70 of about 5,462,613 (380)

Cytogenomic features of Richter transformation

Molecular Cytogenetics, 2023
Background Richter transformation (RT) is the development of aggressive lymphoma in patients with chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL). This rare disease is characterised by dismal prognosis.
Renata Woroniecka, Grzegorz Rymkiewicz, Zbigniew Bystydzienski, Barbara Pienkowska-Grela, Jolanta Rygier, Natalia Malawska, Katarzyna Wojtkowska, Nikolina Goral, Katarzyna Blachnio, Marcin Chmielewski, Magdalena Bartnik-Glaska, Beata Grygalewicz   +11 more
doaj   +1 more source

A multi-color fast-switching microfluidic droplet dye laser [PDF]

, 2009
We describe a multi-color microfluidic dye laser operating in whispering gallery mode based on a train of alternating droplets containing solutions of different dyes; this laser is capable of switching the wavelength of its emission between 580 nm and ...
Abate, Adam R., Agresti, Jeremy J., Li, Zhenyu, Psaltis, Demetri, Tang, Sindy K. Y., Weitz, David A., Whitesides, George M.   +6 more
core   +1 more source

Combination immunotherapy induces distinct T-cell repertoire responses when administered to patients with different malignancies. [PDF]

, 2020
BackgroundCTLA-4 blockade with ipilimumab is Food and Drug Administration-approved for melanoma as a monotherapy and has been shown to modulate the circulating T-cell repertoire.
Cham, Jason, Fong, Grant, Fong, Lawrence, He, Tao, Kwek, Serena, Oh, David Y, Paciorek, Alan, Zhang, Li   +7 more
core   +1 more source

Insights into pegRNA design from editing of the cardiomyopathy‐associated phospholamban R14del mutation

FEBS Letters, EarlyView.
This study reveals how prime editing guide RNA (pegRNA) secondary structure and reverse transcriptase template length affect prime editing efficiency in correcting the phospholamban R14del cardiomyopathy‐associated mutation. Insights support the design of structurally optimized enhanced pegRNAs for precise gene therapy.
Bing Yao, Qiangbing Yang, Christian J.B. Snijders Blok, Mark A. Daniels, Pieter A. Doevendans, Raymond Schiffelers, Joost P.G. Sluijter, Zhiyong Lei   +7 more
wiley   +1 more source

Evaluation of CD38 expression in Sudanese patients with chronic lymphocytic leukemia

BMC Research Notes, 2018
Objective The objective of this study was to evaluate the cluster of differentiation-38 (CD38) expression in Sudanese patients with chronic lymphocytic leukemia (CLL) and to determine its association with clinical and laboratory characteristics of the ...
Enaam Abdelrhman Abdelgader, Nada Hassan Eltayeb, Tasniem Ahmed Eltahir, Osama Ali Altayeb, Eman Abbass Fadul, Eldirdiri M. Abdel Rahman, Tarig H. Merghani   +6 more
doaj   +1 more source

Single‐cell insights into the role of T cells in B‐cell malignancies

FEBS Letters, EarlyView.
Single‐cell technologies have transformed our understanding of T cell–tumor cell interactions in B‐cell malignancies, revealing new T‐cell subsets, functional states, and immune evasion mechanisms. This Review synthesizes these findings, highlighting the roles of T cells in pathogenesis, progression, and therapy response, and underscoring their ...
Laura Llaó‐Cid
wiley   +1 more source

Information Preserving Component Analysis: Data Projections for Flow Cytometry Analysis

, 2008
Flow cytometry is often used to characterize the malignant cells in leukemia and lymphoma patients, traced to the level of the individual cell. Typically, flow cytometric data analysis is performed through a series of 2-dimensional projections onto the ...
Alfred O. Hero Iii, Kevin M. Carter, Raviv Raich, Student Member, William G. Finn   +4 more
core   +3 more sources

Duramycin-induced calcium release in cancer cells [PDF]

, 2015
Introduction: Duramycin through binding with phosphatidylethanolamine (PE) has shown potential to be an effective anti-tumour agent. However its mode of action in relation to tumour cells is not fully understood.
Broughton, Laura J., Crow, Chris, Madden, Leigh A., Maraveyas, Anthony   +3 more
core   +1 more source

Bi-lineage acute leukemia; a case with B-lymphoblasts and myeloid blasts [PDF]

Journal of Preventive Epidemiology, 2019
Mixed phenotypic acute leukemia (MPAL) is classified under acute leukemia of ambiguous lineage. Most reported cases of acute ambiguous leukemia belong to bi-phenotypic leukemia. However, bi-lineage leukemia is rare.
Esmaeil Shahabi Satlsar, Farahnaz Ghahremanfard, Anahid Nabavi, Mohammad Moslehabadi Farahani   +3 more
doaj  

A rapid and reliable method of counting neurons and other cells in brain tissue: a comparison of flow cytometry and manual counting methods

Frontiers in Neuroanatomy, 2010
It is of critical importance to understand the numbers and distributions of neurons and non-neurons in the cerebral cortex because cell numbers are reduced with normal aging and by diseases of the CNS.
Christine E Collins, Nicole A Young, David K Flaherty, David C Airey, Jon H Kaas   +4 more
doaj   +1 more source