Results 71 to 80 of about 1,023,678 (195)

CD24 signalling through macrophage Siglec-10 is a target for cancer immunotherapy. [PDF]

, 2019
Ovarian cancer and triple-negative breast cancer are among the most lethal diseases affecting women, with few targeted therapies and high rates of metastasis. Cancer cells are capable of evading clearance by macrophages through the overexpression of anti-
Barkal, Amira A, Barkal, Layla J, Barkal, Sammy A, Brewer, Rachel E, Dorigo, Oliver, Hatakeyama, Jason, Kowarsky, Mark, Krishnan, Venkatesh, Markovic, Maxim, Weissman, Irving L, Zaro, Balyn W   +10 more
core  

The Fluctuations of Leukocytes and Circulating Cytokines in Septic Humanized Mice Vary With Outcome

Frontiers in Immunology, 2019
Sepsis remains a major challenge in translational research given its heterogeneous pathophysiology and the lack of specific therapeutics. The use of humanized mouse chimeras with transplanted human hematopoietic cells may improve the clinical relevance ...
Tomasz Skirecki, Susanne Drechsler, Grazyna Hoser, Mohammad Jafarmadar, Katarzyna Siennicka, Zygmunt Pojda, Jerzy Kawiak, Marcin F. Osuchowski   +7 more
doaj   +1 more source

P1633: LOW SERUM BDNF LEVELS ARE ASSOCIATED WITH LOWER PLATELETS’ CD62P REACTIVITY AND INCREASED BLEEDING TENDENCY IN PATIENTS WITH GAUCHER DISEASE

HemaSphere, 2022
D. Azoulay, M. Naamad, D. Frydman, E. Broide, A. Zimran, G. Stemer, S. Revel-Vilk   +6 more
doaj   +1 more source

A Phospho-SIM in the Antiviral Protein PML is Required for Its Recruitment to HSV-1 Genomes

Cells, 2014
Herpes simplex virus type 1 (HSV-1) is a significant human pathogen that infects a large portion of the human population. Cells deploy a variety of defenses to limit the extent to which the virus can replicate.
Miles C. Smith, Andrew C. Box, Jeffrey S. Haug, William S. Lane, David J. Davido   +4 more
doaj   +1 more source

Single-cell insights into immune dysregulation in rheumatoid arthritis flare versus drug-free remission

Nature Communications
Immune-mediated inflammatory diseases (IMIDs) are typically characterised by relapsing and remitting flares of inflammation. However, the unpredictability of disease flares impedes their study.
Kenneth F. Baker, David McDonald, Gillian Hulme, Rafiqul Hussain, Jonathan Coxhead, David Swan, Axel R. Schulz, Henrik E. Mei, Lucy MacDonald, Arthur G. Pratt, Andrew Filby, Amy E. Anderson, John D. Isaacs   +12 more
doaj   +1 more source

Breast Cancer and Tumor Microenvironment: The Crucial Role of Immune Cells

Current Oncology
Breast cancer is the most common type of cancer in women and the second leading cause of death by cancer. Despite recent advances, the mortality rate remains high, underlining the need to develop new therapeutic approaches.
Tânia Moura, Paula Laranjeira, Olga Caramelo, Ana M. Gil, Artur Paiva   +4 more
doaj   +1 more source

Imaging Flow Cytometry: Development, Present Applications, and Future Challenges

Methods and Protocols
Imaging flow cytometry (ImFC) represents a significant technological advancement in the field of cytometry, effectively merging the high-throughput capabilities of flow analysis with the detailed imaging characteristics of microscopy.
Savvas Dimitriadis, Lefkothea Dova, Ioannis Kotsianidis, Eleftheria Hatzimichael, Eleni Kapsali, Georgios S. Markopoulos   +5 more
doaj   +1 more source

Challenges and Clinical Relevance in Diagnosing Metastatic Cells From Non‐Hematopoietic Malignancies in Bone Marrow Aspirates

Cancer Medicine
Introduction The causes of cytopenias are numerous, and the bone marrow aspirate helps to identify them. In rare cases, these cytopenias are due to bone marrow metastases from solid cancers.
Elise Kaspi, Charlotte Grosdidier, Yaël Berda‐Haddad, Maud Arpin, Sylvie Cointe, Shirley Fritz, Amandine Bonifay, Marie Koubi, Carine Jiguet‐Jiglaire, Patrice Roll, Diane Frankel   +10 more
doaj   +1 more source

Flow Cytometry as a Diagnostic Tool in the Early Diagnosis of Aggressive Lymphomas Mimicking Life-Threatening Infection

Case Reports in Medicine, 2011
Aggressive lymphomas can present with symptoms mimicking life-threatening infection. Flow cytometry (FC) is usually recommended for the classification and staging of lymphomas in patients with organomegaly and atypical cells in effusions and blood, after
Nikolaos J. Tsagarakis, Nektaria A. Kentrou, Georgios Kakiopoulos, Georgios Androutsos, Athanasios Galanopoulos, Christos Michaelidis, Dimitra Rontogianni, Apostolos Tolis, Stavroula Chini, Georgios Gortzolidis, Konstantinos A. Papadimitriou, Dimitra Skoumi, Konstantina Tzanetou, Georgios Paterakis   +13 more
doaj   +1 more source

P068 | ABNORMAL CD33 EXPRESSION ON BLAST CELLS PREDICTS ELN2022 ADVERSE RISK ACUTE MYELOID LEUKEMIA

Haematologica
Multiparametric flow cytometry (MFC) is useful at diagnosis and during therapy by measuring minimal residual disease in acute myeloid leukemia (AML) patients (pts).
D. Bertoli, V. Giustini, C. Giupponi, V. Quaresima, D. Moratto, C. Cattaneo, G. Rossi, A. Tucci, D. Brugnoni, G. Biasiotto, E. Borlenghi, M. Chiarini   +11 more
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