Results 91 to 100 of about 3,019,828 (293)

CDK11 inhibition induces cytoplasmic p21WAF1 splice variant by p53 stabilisation and SF3B1 inactivation

open access: yesMolecular Oncology, EarlyView.
CDK11 inhibition stabilises the tumour suppressor p53 and triggers the production of an alternative p21WAF1 splice variant p21L, through the inactivation of the spliceosomal protein SF3B1. Unlike the canonical p21WAF1 protein, p21L is localised in the cytoplasm and has reduced cell cycle‐blocking activity.
Radovan Krejcir   +12 more
wiley   +1 more source

Measurement of vortex flow fields [PDF]

open access: yes
A 3-D laser fluorescence anemometer (LFA) was designed, built, and demonstrated for use in the Langley 16 x 24 inch Water Tunnel. Innovative optical design flexibility combined with compact and portable data acquisition and control systems were ...
Ambur, Todd A.   +3 more
core   +1 more source

A method for calculating the effects of design errors and measurement errors on pump performance [PDF]

open access: yes, 1972
Technique has been developed for calculating effects of design errors and measurement errors on pump performance. Error equations and charts are utilized to relate amount of error in given performance parameter to amount of error in given design or ...
Anderson, D. A.
core   +1 more source

Flow measurement inside a zinc-nickel flow cell battery using FBG based sensor system [PDF]

open access: yes, 2019
Downloading of the abstract is permitted for personal use only. A detailed knowledge of the internal flow distribution inside a zinc-nickel flow battery is of critical importance to ensure smooth flow of the electrolyte through the battery cell and ...
Fabian, M.   +7 more
core   +2 more sources

A Natural Gas Energy Metering Method Based on Density-Sound Velocity Correlation

open access: yesSensors
This paper proposes a method for metering natural gas energy based on the correlation between density and sound velocity. The technique integrates physical property correlation models with measured parameters, such as temperature, pressure, sound ...
Bin Zhang   +6 more
doaj   +1 more source

Design and Implementation of a Self-Powered Smart Water Meter

open access: yesSensors, 2019
Smart cities require interactive management of water supply networks and water meters play an important role in such a task. As compared to fully mechanical water meters, electromechanical water meters or fully electronic water meters can collect real ...
Xue Jun Li, Peter Han Joo Chong
doaj   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

open access: yesMolecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia   +9 more
wiley   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

open access: yesMolecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz   +15 more
wiley   +1 more source

Use of small turbine-type flowmeters to measure flow in large pipes [PDF]

open access: yes, 1972
Measurement of mass flow in large pipes using small turbine-type flowmeters is discussed. Experiments for determining accuracy of flowmeter and applicability to various types of flow measurement are reported.
Hobart, H. F., Minkin, H. L.
core   +1 more source

Measurement of turbulent flow in a narrow open channel

open access: yesJournal of Hydrology and Hydromechanics, 2016
The paper presents the experimental results of turbulent flow over hydraulically smooth and rough beds. Experiments were conducted in a rectangular flume under the aspect ratio b/h = 2 (b = width of the channel 0.5 m, and h = flow depth 0.25 m) for both ...
Sarkar Sankar
doaj   +1 more source

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