Results 81 to 90 of about 898,092 (267)

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Study of Flow Stress Models and Ductile Fracture Criteria for CHN327 Nickel-Based Superalloy. [PDF]

Materials (Basel), 2023
Xia Y, Yang W, Yu Y, Teng H, Cheng Q.
europepmc   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Constitutive Equation of Hot Deformation of ZL114A Alloy

Journal of Harbin University of Science and Technology, 2018
At the condition of deformation temperature of 350 ～ 470 ℃，strain rate of 0. 001 ～ 10 s －1， deformation of 50%，hot compression tests for ZL114A alloy were carried out by Gleeble-1500D thermal simulation testing machine. The characteristics of true stress-
KANG Fu-wei, ZHANG Ji-min, FAN De-zhi, WANG Shan-shan   +3 more
doaj   +1 more source

The Flow Stress-Strain and Dynamic Recrystallization Kinetics Behavior of High-Grade Pipeline Steels. [PDF]

Materials (Basel), 2022
Wang L, Ji L, Yang K, Gao X, Chen H, Chi Q.   +5 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Effects of electrical pulse on metal deformation behaviors

Materials Research Express
As a kind of special energy field assisted plastic forming, electric pulse assisted plastic forming combines multiple physical fields, such as thermal, electrical, magnetic and mechanical effects, has multiple effects on metal.
Tao Huang, Fan Yang, Bing-Hui Xing, Ke-Xing Song, Nan Xiang, Yan-Min Zhang, Xue-Wen Chen, Jun-Qing Guo   +7 more
doaj   +1 more source

Forces prediction in micro-grinding single-crystal copper considering the crystallographic orientation

Manufacturing Review, 2018
In the micro-grinding of single-crystal copper, the effect of crystallography becomes significant as the wheel works intra-crystalline. To quantify the effect of crystallographic orientation (CO) related to the cutting direction on the micro-grinding ...
Zhao Man, Ji Xia, Li Beizhi, Liang Steven Y.   +3 more
doaj   +1 more source

Towards an Optimized Artificial Neural Network for Predicting Flow Stress of In718 Alloys at High Temperatures. [PDF]

Materials (Basel), 2023
Zhang C, Shi Q, Wang Y, Qiao J, Tang T, Zhou J, Liang W, Chen G.   +7 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source