Results 1 to 10 of about 106,245 (320)

Investigation of antibacterial, antifungal, and antioxidant activities in novel poly(DEAEMA‐co‐EMA)/polyindole composites

Polymer Engineering &Science, Volume 65, Issue 6, Page 3178-3192, June 2025.
Schematic illustration of prepared poly(DEAEMA‐co‐EMA)/PIN composities and 3D AFM image. Abstract In the current study, in the first stage, amphiphilic poly(2‐diethylamino ethylmethacrylate‐co‐ethyl methacrylate) [Poly(DEAEMA‐co‐EMA)] was synthesized from the 2‐diethylamino ethylmethacrylate (DEAEMA) and the ethyl methacrylate (EMA) using the free ...
Safiye Elif Korcan, Cengiz Soykan, Burak Tüfekçi, Naci Ömer Alayunt, Şah İsmail Çivi   +4 more
wiley   +1 more source

Assessments of CYP‐Inhibition‐Based Drug–Drug Interactions Between Tofacitinib and Lipid‐Lowering Agents in Rats Both In Vitro and In Vivo

Pharmacology Research &Perspectives, Volume 13, Issue 3, June 2025.
ABSTRACT Tofacitinib is a widely used medication for the treatment of arthritis. It has been reported that some patients experience abnormal cholesterol levels following treatment, leading to recommendations for the coadministration of lipid‐lowering drugs such as statins.
Hang Yang, Shuanghu Wang, Quan Zhou, Peiwu Geng, Zebei Lu, Qinrong Lin, Chunhong Chen, Yunfang Zhou, Jianping Cai, Dapeng Dai   +9 more
wiley   +1 more source

Polymyositis associated with dyspnoea and interstitial lung disease in a dog (Canis familiaris)

Veterinary Record Case Reports, Volume 13, Issue 2, June 2025.
Abstract A 5‐year‐old, female, spayed coonhound was evaluated for progressive dyspnoea, weakness and weight loss. The patient had increased inspiratory and expiratory respiratory effort and generalised skeletal muscle atrophy. Thoracic radiographs and computed tomography revealed interstitial lung disease. Magnetic resonance imaging revealed multifocal
Kaycee Daentl, Victoria Umana, Stefanie DeMonaco   +2 more
wiley   +1 more source

Hemorrhage Incognito

Transplant Infectious Disease, Volume 27, Issue 2, March/April 2025.
Scott Borgetti, Katherine Ortell, Varun Phadke, Danielle Haakinson, Steven Fischer, Maricar Malinis   +5 more
wiley   +1 more source

Natural History of Idiosyncratic Drug‐Induced Liver Injury and Prognostic Models

Liver International, Volume 45, Issue 6, June 2025.
ABSTRACT Background and Aims: Drug‐induced liver injury (DILI) remains a leading cause of acute liver failure worldwide. Drugs such as isoniazid, alone or in combination with other anti‐tuberculosis drugs, as well as a growing number of herbal and complementary medicines, have been implicated in most cases of acute liver failure in registry studies ...
Harshad C. Devarbhavi, Raúl J. Andrade
wiley   +1 more source

Comparative efficacy of selenoureido carbonic anhydrase inhibitors and azole antifungal drugs against clinical isolates of Malassezia pachydermatis

Veterinary Dermatology, Volume 36, Issue 3, Page 302-313, June 2025.
Background – Malassezia pachydermatis (MP) is implicated in severe dermatitis and otitis externa (OE) of companion animals and recently gained attention for its increasing resistance to azole compounds. For this reason, developing novel therapeutic strategies is of great interest. In a previous work, we used reference yeast isolates to evaluate several
Costanza Spadini, Nicolò Mezzasalma, Amienwanlen Eugene Odigie, Andrea Angeli, Fabrizio Carta, Silvia Selleri, Emanuele Gandolfo, Simone Taddei, Valentina Franceschi, Sergio Minesso, Claudiu T. Supuran, Clotilde Silvia Cabassi   +11 more
wiley   +1 more source

Mutations in TAC1B: a Novel Genetic Determinant of Clinical Fluconazole Resistance in Candida auris

mBio, 2020
Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, and yet it remains unknown what mechanisms
Jeffrey M. Rybak, José F. Muñoz, Katherine S. Barker, Josie E. Parker, Brooke D. Esquivel, Elizabeth L. Berkow, Shawn R. Lockhart, Lalitha Gade, Glen E. Palmer, Theodore C. White, Steve L. Kelly, Christina A. Cuomo, P. David Rogers   +12 more
doaj   +2 more sources

Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance. [PDF]

mBio, 2019
Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be associated with suboptimal microbiological and clinical outcomes. Exposure to fluconazole causes dynamic
Aller, Altamirano, Arechavala, Bicanic, Bicanic, Boeva, Chang, Chen, Dannaoui, DePristo, Drusano, Harrison, Li, Longley, Loyse, Martin, Mayanja-Kizza, McKenna, Molloy, Mondon, Neely, Nixon, Nussbaum, Saag, Sionov, Sionov, Stone, Stott, Stott, Sudan, Wiederhold, Witt   +31 more
core   +2 more sources

MDR1 overexpression combined with ERG11 mutations induce high-level fluconazole resistance in Candida tropicalis clinical isolates

BMC Infectious Diseases, 2018
Background Marked increases in fluconazole resistance in Candida tropicalis have been recently reported. In this study, the molecular mechanisms behind fluconazole resistance were investigated. Methods Twenty-two C.
Longyang Jin, Zhuorui Cao, Qi Wang, Yichen Wang, Xiaojuan Wang, Hongbin Chen, Hui Wang   +6 more
doaj   +2 more sources

Effect of fluconazole dose on the extent of fluconazole-triazolam interaction [PDF]

British Journal of Clinical Pharmacology, 1996
1Azole antimycotics interact with the short acting hypnotic triazolam. The effect of fluconazole dose on the extent of fluconazole‐triazolam interaction was investigated in a double‐blind, randomized cross‐over study of four phases. 2Eight healthy volunteers received either 50 mg, 100 mg or 200 mg (400 mg on day 1) of fluconazole or placebo orally ...
Pertti J. Neuvonen, Klaus T. Olkkola, Anu Varhe   +2 more
openaire   +5 more sources