Results 11 to 20 of about 110,241 (334)
Mutations in
mBio, 2020 Candida auris has emerged as a multidrug-resistant pathogen of great clinical concern. Approximately 90% of clinical C. auris isolates are resistant to fluconazole, the most commonly prescribed antifungal agent, and yet it remains unknown what mechanisms
Jeffrey M. Rybak +12 more
doaj +2 more sources
Fluconazole Monotherapy Is a Suboptimal Option for Initial Treatment of Cryptococcal Meningitis Because of Emergence of Resistance. [PDF]
mBio, 2019 Cryptococcal meningitis is a lethal disease with few therapeutic options. Induction therapy with fluconazole has been consistently demonstrated to be associated with suboptimal microbiological and clinical outcomes. Exposure to fluconazole causes dynamic
Aller +31 more
core +2 more sources
BMC Infectious Diseases, 2018 Background Marked increases in fluconazole resistance in Candida tropicalis have been recently reported. In this study, the molecular mechanisms behind fluconazole resistance were investigated. Methods Twenty-two C.
Longyang Jin +6 more
doaj +2 more sources
Fluconazole-resistant Candida parapsilosis: A new emerging threat in the fungi arena
Frontiers in Fungal Biology, 2022 Candida parapsilosis is a leading cause of invasive candidiasis in southern Europe, Latin America and Asia. C. parapsilosis has been mostly considered susceptible to triazoles, but fluconazole resistance is on the rise in some countries.
Pilar Escribano +4 more
doaj +2 more sources
Effect of fluconazole dose on the extent of fluconazole-triazolam interaction. [PDF]
British Journal of Clinical Pharmacology, 1996 1Azole antimycotics interact with the short acting hypnotic triazolam. The effect of fluconazole dose on the extent of fluconazole‐triazolam interaction was investigated in a double‐blind, randomized cross‐over study of four phases. 2Eight healthy volunteers received either 50 mg, 100 mg or 200 mg (400 mg on day 1) of fluconazole or placebo orally ...
Anu Varhe +2 more
openalex +5 more sources
Effect of fluconazole prophylaxis on Candida fluconazole susceptibility in premature infants [PDF]
Journal of Antimicrobial Chemotherapy, 2018 Objectives Extremely premature infants are at high risk of developing invasive candidiasis; fluconazole prophylaxis is safe and effective for reducing invasive candidiasis in this population but further study is needed. We sought to better understand the
J. Autmizguine +42 more
semanticscholar +4 more sources
Current Medical Mycology, 2017 Background and Purpose: The frequency of opportunistic fungal infections in immunocompromised patients, especially by Candida species, has sharply increased in the last few decades.
Fahimeh Alizadeh +2 more
doaj +2 more sources
Pathogens, 2023 Neuromeningeal cryptococcosis is a life-threatening infection of the central nervous system, caused by encapsulated yeast belonging to the Cryptococcus neoformans and Cryptococcus gattii species complexes. Recent data showed that virulence and antifungal
Sébastien Bertout +5 more
doaj +4 more sources
Statins as Antifungal Agents: A Review on Drug Repurposing and Nanotechnology-Driven Delivery Strategies. [PDF]
Fundam Clin PharmacolABSTRACT This review highlights the integration of drug repurposing and nanotechnology‐driven delivery strategies as innovative approaches to enhance the antifungal activity of statins against mucosal candidiasis, providing a framework for future translational research and clinical application.
E Silva DM +8 more
europepmc +2 more sources
Antibiotics, 2022 The objectives of this study were to investigate the incidence of candidemia, as well as the factors associated with Candida species distribution and fluconazole resistance, among patients admitted to the intensive care unit (ICU) during the COVID-19 ...
C. Routsi +13 more
semanticscholar +1 more source