Results 31 to 40 of about 82,470 (284)

Repurposing of terconazole as an anti Trypanosoma cruzi agent [PDF]

, 2019
Trypanosoma cruzi is the causative agent of Chagas disease, a parasitic infection endemic in Latin America. Currently there are no effective treatments for the chronic phase of the disease, when most patients are diagnosed, therefore the development of ...
Martínez Sayé, Melisa Soledad, Miranda, Mariana Reneé, Pereira, Claudio Alejandro, Reigada, Chantal, Valera Vera, Edward Augusto   +4 more
core   +1 more source

Synergistic Effects of Amiodarone and Fluconazole on Candida tropicalis Resistant to Fluconazole [PDF]

Antimicrobial Agents and Chemotherapy, 2013
ABSTRACT There have recently been significant increases in the prevalence of systemic invasive fungal infections. However, the number of antifungal drugs on the market is limited in comparison to the number of available antibacterial drugs. This fact, coupled with the increased frequency of cross-resistance, makes it necessary to
Thalles B. Grangeiro, Cecília Rocha da Silva, Danielle Silveira Macêdo, José Júlio Costa Sidrim, Bruno C. Cavalcanti, Maria Rozzelê Ferreira Ângelo, Hemerson Iury Ferreira Magalhães, Marina Duarte Pinto Lobo, Hélio Vitoriano Nobre Júnior, João Batista de Andrade Neto, Manoel Odorico de Moraes, Raimunda Sâmia Nogueira Brilhante   +11 more
openaire   +3 more sources

A randomized, double-blind study of amorolfine 5% nail lacquer with oral fluconazole compared with oral fluconazole alone in the treatment of fingernail onychomycosis

Indian Journal of Dermatology, 2019
Background: It is a challenge to treat onychomycosis due to frequent treatment failures and relapses. Systemic and topical therapies need to be combined to improve cure rates.
Somodyuti Chandra, Karan Sancheti, Indrashis Podder, Anupam Das, Tushar Kanti Sarkar, Moitreyee Chowdhury, Amrita Sil, Susmita Bhattacharya, Nilay Kanti Das   +8 more
doaj   +1 more source

Fluconazole Assists Berberine To Kill Fluconazole-Resistant Candida albicans [PDF]

Antimicrobial Agents and Chemotherapy, 2013
ABSTRACT It was found in our previous study that berberine (BBR) and fluconazole (FLC) used concomitantly exhibited a synergism against FLC-resistant Candida albicans in vitro . The aim of the present study was to clarify how BBR and FLC worked synergistically and the underlying mechanism ...
De-Dong Li, Eleftherios Mylonakis, Yi Xu, Ming-Bang Li, Lan-Xue Zhao, Dan-Dan Hu, Yuanying Jiang, Da-Zhi Zhang, Liang-hua Zhu, Hua Quan, Yan Wang   +10 more
openaire   +3 more sources

Molecular Evaluation of the mRNA Expression of the ERG11, ERG3, CgCDR1, and CgSNQ2 Genes Linked to Fluconazole Resistance in Candida glabrata in a Colombian Population

Journal of Fungi
Introduction: The study of Candida glabrata genes associated with fluconazole resistance, from a molecular perspective, increases the understanding of the phenomenon with a view to its clinical applicability.
Leidy Yurany Cárdenas Parra, Ana Elisa Rojas Rodríguez, Jorge Enrique Pérez Cárdenas, Juan Manuel Pérez-Agudelo   +3 more
doaj   +1 more source

Delineation of the Direct Contribution of Candida auris ERG11 Mutations to Clinical Triazole Resistance

Microbiology Spectrum, 2021
Resistance to fluconazole is one of clinical characteristics most frequently challenging the treatment of invasive Candida auris infections, and is observed among >90% of all characterized clinical isolates. In this work, the native C. auris ERG11 allele
Jeffrey M. Rybak, Cheshta Sharma, Laura A. Doorley, Katherine S. Barker, Glen E. Palmer, P. David Rogers   +5 more
doaj   +1 more source

Effect of fluconazole prophylaxis on Candida fluconazole susceptibility in premature infants [PDF]

Journal of Antimicrobial Chemotherapy, 2018
Abstract Objectives Extremely premature infants are at high risk of developing invasive candidiasis; fluconazole prophylaxis is safe and effective for reducing invasive candidiasis in this population but further study is needed.
Julie Autmizguine, P Brian Smith, Kristi Prather, Catherine Bendel, Girija Natarajan, Margarita Bidegain, David A Kaufman, David J Burchfield, Ashley S Ross, Paresh Pandit, Wiley A Schell, Jamie Gao, Daniel K Benjamin, Scott MacGilvray, Kelly Wade, Margarita Bidegain, Rune Toms, Neil Finer, David Burchfield, Dan Stewart, Antonio Arrieta, Shahnaz Duara, Seetha Shankaran, Jonathan Nedrelow, Robert White, Anand Kantak, Karen Shattuck, Mohan Pammi, Kathleen Kennedy, Pablo Sanchez, Catherine Bendel, Ramasubbareddy Dhanireddy, Barry Bloom, Mark Hudak, Agnes Perenyi, Natalie Neu, Echezona Ezeanolue, Roger Kim, Mark Hudak, Ashley Ross, Gratias Mundakel, Paresh Pandit, Ashley Ross, Brenda Poindexter, Phillip Gordon   +44 more
openaire   +3 more sources

Redefining pleiotropic drug resistance in a pathogenic yeast: Pdr1 functions as a sensor of cellular stresses in Candida glabrata

mSphere, 2023
Candida glabrata is a prominent opportunistic fungal pathogen of humans. The increasing incidence of C. glabrata infections is attributed to both innate and acquired resistance to antifungals.
Andrew N. Gale, Matthew W. Pavesic, Timothy J. Nickels, Zhuwei Xu, Brendan P. Cormack, Kyle W. Cunningham   +5 more
doaj   +1 more source

Examination of Fluconazole-Induced Alopecia in an Animal Model and Human Cohort. [PDF]

, 2019
Fluconazole-induced alopecia is a significant problem for patients receiving long-term therapy. We evaluated the hair cycle changes of fluconazole in a rat model and investigated potential molecular mechanisms.
Aaron, Phylicia A, Affolter, Verena K, Dennis, Michael, Everett, Angela D, Fedor, Dawn M, Gelli, Angie, Krois, Charles R, McHardy, Ian, Napoli, Joseph L, Sharon, Victoria R, Singapuri, Anil, Thompson, George R, Varjonen, E Katarina, White, Stephen D, Wiederhold, Nathan P, Yoo, Hong Sik   +15 more
core  

Creation and assessment of a clinical predictive calculator and mortality associated with Candida krusei bloodstream infections [PDF]

, 2018
Background Candida krusei bloodstream infection (CK BSI) is associated with high mortality, but whether this is due to underlying comorbidities in affected patients or the organism itself is unknown.
Hsueh, Kevin, Kronen, Ryan, Lin, Charlotte, Powderly, William G, Spec, Andrej   +4 more
core   +2 more sources