Synergistic and antagonistic drug interactions in the treatment of systemic fungal infections
eLife, 2020 Invasive fungal infections cause 1.6 million deaths annually, primarily in immunocompromised individuals. Mortality rates are as high as 90% due to limited treatments.
Morgan A Wambaugh +5 more
doaj +1 more source
Fluconazole-resistant Candida parapsilosis: A new emerging threat in the fungi arena
Frontiers in Fungal Biology, 2022 Candida parapsilosis is a leading cause of invasive candidiasis in southern Europe, Latin America and Asia. C. parapsilosis has been mostly considered susceptible to triazoles, but fluconazole resistance is on the rise in some countries.
Pilar Escribano +4 more
doaj +1 more source
Antiprotozoal Activity of Highly Substituted Pyrazole and Pyrimidine Derivatives
ChemMedChem, EarlyView.Based on previously identified antimalarial agents, a series of highly substituted pyrazole and pyrimidines derivatives has been synthesized and tested for antiplasmodial and antileishmanial activity. Selected derivatives show promising antiplasmodial effect with a predicted favorable pharmacokinetic profile.
Matteo Lusardi +7 more
wiley +1 more source
Ambroxol Hydrochloride Combined with Fluconazole Reverses the Resistance of Candida albicans to Fluconazole [PDF]
Frontiers in Cellular and Infection Microbiology, 2017 In this study, we found that ambroxol hydrochloride (128 μg/mL) exhibits synergistic antifungal effects in combination with fluconazole (2 μg/mL) against resistant planktonic Candida albicans (C. albicans) cells. This combination also exhibited synergistic effects against resistant C.
Xiuyun Li +5 more
openaire +3 more sources
Voriconazole treatment of Candida tropicalis meningitis: persistence of (1,3)-b-D-glucan in the cerebrospinal fluid is a marker of clinical and microbiological failure [PDF]
, 2016 Introduction: Infections are still the most common complications of cerebral shunt procedures. Even though fungal etiologies are considered to be rare, they are associated with significant morbidity and mortality.
Brunetti, Grazia +7 more
core +2 more sources
Clinical Pharmacology in Drug Development, EarlyView.Abstract Valemetostat tosylate (valemetostat) is a dual inhibitor of enhancer of zeste homolog (EZH) 2 and EZH1, approved in Japan for the treatment of relapsed/refractory peripheral T‐cell lymphoma and adult T‐cell leukemia/lymphoma. This Phase I, open‐label study evaluated the pharmacokinetics and safety of a single 50‐mg oral dose of valemetostat in
Masaya Tachibana +8 more
wiley +1 more source
Cell wall composition and biofilm formation of azoles-susceptible and -resistant Candida glabrata strains [PDF]
, 2016 In the present study, three strains of Candida glabrata have been investigated to shed light on the mechanisms involved in azole resistance during adherence and biofilm formation.
Angiolella, Letizia +6 more
core +5 more sources
Emerging fluconazole resistance: Implications for the management of cryptococcal meningitis
Medical Mycology Case Reports, 2018 We present the case of an HIV-seropositive individual with cryptococcal meningitis who was found to have a fluconazole resistant strain of Cryptococcus neoformans.
Edward Mpoza, Joshua Rhein, Mahsa Abassi
doaj +1 more source
Anti-Candida targets and cytotoxicity of casuarinin isolated from Plinia cauliflora leaves in a bioactivity-guided study [PDF]
, 2013 Peer reviewedPublisher ...
Gow, Neil A R +8 more
core +4 more sources
Food Frontiers, EarlyView.Four major masala spices, Chaat, Pav Bhaji, Sambhar, and Tandoori, were analyzed using advanced multiplex mass spectrometry techniques. A total of 45 aroma compounds and 98 secondary metabolites were identified. These findings underscore the potential of masala spices not only as flavoring agents but also as potential food additives with antimicrobial ...
Mai E. Hussein +5 more
wiley +1 more source