Results 171 to 180 of about 10,990 (185)

Impact of tolerance to fluconazole on treatment response in Candida albicans bloodstream infection

Mycoses, 2020
AbstractBackgroundTreatment of Candida albicans bloodstream infection with fluconazole is associated with significant mortality despite in vitro susceptibility to the drug.ObjectivesWe sought to determine whether tolerance to fluconazole is predictive of treatment failure.MethodsWe reviewed patients with monomicrobial C albicans bloodstream infection ...
Tal Levinson, Alon Dahan, Anna Novikov, Yael Paran, Judith Berman, Ronen Ben‐Ami   +5 more
openaire   +2 more sources

Electrochemical Strategy for Eradicating Fluconazole-Tolerant Candida albicans Using Implantable Titanium

ACS Applied Materials & Interfaces, 2019
A persistent problem in modern health care derives from the overwhelming presence of antibiotic-resistant microbes on biomaterials, more specifically, fungal growth on metal-based implants. This study seeks to investigate the antifungal properties of low-level electrochemical treatments delivered using titanium electrodes against Candida albicans.
Eloise Parry-Nweye, Nna-Emeka Onukwugha, Sricharani Rao Balmuri, Jackie L. Shane, Dongyeop Kim, Hyun Koo, Tagbo H. R. Niepa   +6 more
openaire   +2 more sources

Efficacy, safety and toleration of fluconazole suppositories in the treatment of oral candidosis

Mycoses, 1999
An open multicentre, non‐comparative study was conducted in three countries to investigate the efficacy, safety and tolerance of fluconazole suppositories in the treatment of oropharyngeal candidosis. Patients received fluconazole 100 mg day−1 in the form of suppositories or capsules.
A, Plettenberg, A, Stoehr, W, Heise, F, Schlote, E, Sarnow, M, Migdal   +5 more
openaire   +2 more sources

Emerging Evidence of Selection of Fluconazole-Tolerant Fungi in Surgical Intensive Care Units

Archives of Surgery, 1997
To determine whether increased use of fluconazole has coincided with a shift in the relative proportion of fluconazole-tolerant species isolated from critically ill surgical patients in 2 university hospitals.Microbiological data and fluconazole administration frequencies were reviewed among patients treated in the surgical intensive care units (SICUs)
T G, Gleason, A K, May, D, Caparelli, B M, Farr, R G, Sawyer   +4 more
openaire   +2 more sources

Pharmacokinetics and tolerance of fluconazole suppositories in healthy volunteers.

Arzneimittel-Forschung, 1993
Fluconazole (Diflucan, CAS 86386-73-4) suppositories offer a novel way to administer this systemically active antimycotic. The pharmacokinetics and toleration of this new formulation have now been examined in healthy adult volunteers. In crossover experiments the bioequivalence was demonstrated for 200 mg suppositories and 200 mg capsules, and for 25 ...
G, Pfaff, T, Zimmermann, P, Lach, R, Yeates, G, Simon, A, Wildfeuer   +5 more
openaire   +1 more source

The impact of growth conditions on biofilm formation and the cell surface hydrophobicity in fluconazole susceptible and tolerant Candida albicans

Folia Microbiologica, 2014
The influence of acidic (5.6) and neutral (7.0) pH and glucose concentrations (0.9 and 2 %) was determined in in vitro biofilm formation and the cell surface hydrophobicity (CSH) in fluconazole (FLC) susceptible and tolerant yeasts of Candida albicans.
Anna, Kolecka, Dušan, Chorvát, Helena, Bujdáková   +2 more
openaire   +2 more sources

The stress-protectant molecule trehalose mediates fluconazole tolerance inCandida glabrata

AbstractThe incidence of non-albicans Candidainfections has witnessed a substantial rise in recent decades.Candida glabrata (Nakaseomyces glabratus), an opportunistic human fungal pathogen, is accountable for both superficial mucosal and life-threatening bloodstream infections, particularly in immunocompromised individuals.
Qingjuan Zhu, Stefanie Wijnants, Regina Feil, Rudy Vergauwen, John E. Lunn, Mieke Van Ende, Patrick Van Dijck   +6 more
openaire   +1 more source

Achieving Resilience in Aging: How Mitochondrial Modulation Drives Age-associated Fluconazole Tolerance inCryptococcus neoformans

ABSTRACTCryptococcus neoformans(Cn) is an opportunistic fungal microorganism that causes life-threatening meningoencephalitis. During the infection, the microbial population is heterogeneously composed of cells with varying generational ages, with older cells accumulating during chronic infections.
Kyungyoon Yoo, Natalia Kronbauer Oliveira, Somanon Bhattacharya, Bettina C. Fries   +3 more
openaire   +2 more sources

[Fluconazole in therapy of candidiasis of the oropharyngeal space in patients with HIV infection. Results of an open multicenter study of assessing the effectiveness and tolerance of fluconazole].

Medizinische Klinik (Munich, Germany : 1983), 1992
50 HIV-positive patients (CDC stage III to VI) with oral candidiasis proven by culture and typical clinical findings were treated with fluconazole (50 to 100 mg/day) over a period of eight to 22 days. After completion of treatment, clinical signs of oral candidiasis had disappeared in 45/50 patients. In 10/50 patients, however, increased concentrations
B, Tschechne, U, Brunkhorst, M, Ruhnke, M, Trautmann, S, Dempe, H, Deicher   +5 more
openaire   +1 more source

Fluconazole well tolerated in children

Reactions Weekly, 1999
openaire   +1 more source