Results 121 to 130 of about 109,213 (331)
Molecular Oncology, EarlyView.This study develops a semi‐supervised classifier integrating multi‐genomic data (1404 training/5893 validation samples) to improve homologous recombination deficiency (HRD) detection in breast cancer. Our method demonstrates prognostic value and predicts chemotherapy/PARP inhibitor sensitivity in HRD+ tumours.
Rong Zhu +12 more
wiley +1 more source
Post-metamorphic fluid infiltration into granulites from the Adirondack Mountains, USA [PDF]
Post-metamorphic effects in the anorthosites of the Adirondacks, New York were described. Calcite-chlorite-sericite assemblages occur as veins, in disseminated form and as clots, and document retrograde fluid infiltration.
Morrison, J., Valley, John W.
core +1 more source
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
Molecular Oncology, EarlyView.G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren +16 more
wiley +1 more source
Stable isotope studies on granulites from the high grade terrain of Southern India [PDF]
Fluid inclusion and petrologic characteristics of South India granulites and their bearing on the sources of metamorphic fluids are discussed. This paper served as a review and an introduction to the next paper by D. Jackson.
Harris, N. B. W. +3 more
core +1 more source
Drag forces on inclusions in classical fields with dissipative dynamics
, 2010 We study the drag force on uniformly moving inclusions which interact linearly with dynamical free field theories commonly used to study soft condensed matter systems.
A. Naji +26 more
core +3 more sources
Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer
Molecular Oncology, EarlyView.Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte +10 more
wiley +1 more source
Petroleum Exploration and Development, 2015 Karst reservoir paleofluid types of the Ordovician formation in the Tarim Basin are restored based on the analysis of element boron of filled mud, the test of fluid inclusions homogenization temperature and salinity, liquid anion and hydroxyl isotope of ...
Xiuqin SHAN +5 more
doaj
Methane genesis within olivine-hosted fluid inclusions in dolomitic marble of the Hida Belt, Japan
Progress in Earth and Planetary ScienceAbiotic synthesis of hydrocarbon-bearing fluids during geological processes has a significant impact on the evolution of both the Earth's biosphere and the solid Earth.
Hironobu Harada, Tatsuki Tsujimori
doaj +1 more source
Final report on a study of fluid inclusions in core from Gibson Dome No. 1 bore, Paradox Basin, Utah [PDF]
, 1984 Edwin Roedder
openalex +1 more source
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source