Results 121 to 130 of about 112,408 (351)

Therapeutic applications of a novel humanized monoclonal antibody targeting chemokine receptor CCR9 in pancreatic cancer

open access: yesMolecular Oncology, EarlyView.
C–C chemokine receptor type 9 (CCR9) is an immune checkpoint in pancreatic ductal adenocarcinoma (PDAC). Novel anti‐CCR9 antibody SRB2 was evaluated in combination with cytotoxic chemotherapy in PDAC cells, patient‐derived organoids, patient‐derived xenografts, and humanized mouse models.
Hannah G. McDonald   +18 more
wiley   +1 more source

Magmatic and Metamorphic Fluids in Pegmatite Development: Evidence from Borujerd Complex, Iran [PDF]

open access: yesJournal of Sciences, Islamic Republic of Iran, 2005
The Borujerd complex of western Iran is composed of intrusions and their surrounding contact aureole, with, pegmatites and quartz veins. Pegmatites differ in mineralogy, origin and age, and two groups can be distinguished. The Older Pegmatites (about 120
doaj  

Geological setting of silica in Dehnow-Abid region (Eshghabad northeast) using fluid inclusions studies

open access: yesJournal of Economic Geology, 2017
Introduction Dehnow-Abid area is a part of the geological map of Eshghabad with scale 1:100000 (Aghanabati, 1994) that is located about 20 kilometers northeast of Eshghabad and in the coordinates of 57° 6´ 0" to 57° 10´ 0" eastern longitude and 34° 28 ...
Omid Yazdanpanah, Ali Akbar Hassannezhad
doaj   +1 more source

Curvature correction to the mobility of fluid membrane inclusions [PDF]

open access: yesThe European Physical Journal E, 2016
Using rigorous low-Reynolds-number hydrodynamic theory on curved surfaces, we provide, via a Stokeslet-type approach, a general and concise expression for the leading-order curvature correction to the canonical, planar, Saffman-Delbrück value of the diffusion constant for a small inclusion embedded in an arbitrarily (albeit weakly) curved fluid ...
openaire   +5 more sources

Simultaneous inhibition of TRIM24 and TRIM28 sensitises prostate cancer cells to antiandrogen therapy, decreasing VEGF signalling and angiogenesis

open access: yesMolecular Oncology, EarlyView.
TRIM24 and TRIM28 are androgen receptor (AR) coregulators which exhibit increased expression with cancer progression. Both TRIM24 and TRIM28 combine to influence the response of castrate‐resistant prostate cancer (CRPC) cells to AR inhibitors by mediating AR signalling, regulation of MYC and upregulating VEGF to promote angiogenesis. Castrate‐resistant
Damien A. Leach   +8 more
wiley   +1 more source

Sources of the fluids for metasomatic magnesite of Ismakaevo deposit in the South Ural province (thermokryometry of fluid inclusions)

open access: yesЛитосфера, 2015
Bittern brine nature of fluid inclusions in magnesite of Ismakaevo deposits are confirmed not only by data of Cl-Br ion systematics, but also by methods of microthermometry.
M. T. Krupenin, A. A. Garaeva
doaj   +2 more sources

Fluid and Halide Melt Inclusions of Magmatic Origin in the Ultramafic and Lower Banded Series, Stillwater Complex, Montana, USA [PDF]

open access: yes, 2017
Fluid and melt inclusions trapped in igneous rocks below the platinum-group element (PGE)-rich J-M reef in the Stillwater Complex, Montana provide a physiochemical record of a continuum of high P-T magmatic-hydrothermal and low P-T metamorphic events ...
Bray, C. J.   +4 more
core  

Hydrodynamic Collective Effects of Active Protein Machines in Solution and Lipid Bilayers

open access: yes, 2015
The cytoplasm and biomembranes in biological cells contain large numbers of proteins that cyclically change their shapes. They are molecular machines that can function as molecular motors or carry out many other tasks in the cell.
Kapral, Raymond, Mikhailov, Alexander
core   +1 more source

EMT‐associated bias in the Parsortix® system observed with pancreatic cancer cell lines

open access: yesMolecular Oncology, EarlyView.
The Parsortix® system was tested for CTC enrichment using pancreatic cancer cell lines with different EMT phenotypes. Spike‐in experiments showed lower recovery of mesenchymal‐like cells. This was confirmed with an EMT‐inducible breast cancer cell line.
Nele Vandenbussche   +8 more
wiley   +1 more source

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