Results 111 to 120 of about 380,214 (349)

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Economic Boom and Social Mobility: The Irish Experience [PDF]

In this paper we examine the consequences for social mobility patterns of the unprecedented period of economic growth experienced in Ireland over the 1990s and the implications of developments for current theories of social fluidity.
Christopher T. Whelan, Richard Layte
core  

Gender Fluidity

Felicitas, 2023
The discussion around gender is one of the most lively, complex and sensitive topics of the 21th century. Recently, for example, a term called: ‘gender fluidity’ has emerged. Gender fluidity is a new variation of the idea of gender that rejects a definitive gender categorization. What is the fundamental idea of ‘gender fluidity’? Is it true that gender
openaire   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

EFFECT OF FLASK VIBRATION ON GRAY CAST IRON CHARACTERISTICS PREPARED BY LOST FOAM CASTING

Rekayasa Mesin
Parameter selection in lost foam casting can reduce the casting defect. Flask vibration is a critical parameter that significantly influences the casting quality in the lost foam casting.
Sutiyoko Sutiyoko, Lutiyatmi Lutiyatmi, Suyitno Suyitno, R. Soekrisno   +3 more
doaj   +1 more source

Effect of Cholesterol on Membrane Fluidity and Association of Aβ Oligomers and Subsequent Neuronal Damage: A Double-Edged Sword

Frontiers in Aging Neuroscience, 2018
Background: The beta-amyloid peptide (Aβ) involved in Alzheimer’s disease (AD) has been described to associate/aggregate on the cell surface disrupting the membrane through pore formation and breakage.
E. Fernandez-Perez, F. Sepúlveda, C. Peters, Denisse Bascuñan, Nicolás Riffo-Lepe, Juliana González-Sanmiguel, S. Sánchez, R. Peoples, Benjamín Vicente, L. Aguayo   +9 more
semanticscholar   +1 more source

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Formable Fluidity: The Key Consequence of Information Flow in Cyberpunk Fiction

American and British Studies Annual, 2019
Cyberpunk is one of the most recent subgenres to emerge in science fiction. In the represented world of this subgenre, information is the constituting element of all the flows, frameworks and interactions.
Hossein Mohseni, Kian Soheil
doaj  

Investigation of Fresh Properties of Self-Leveling Cement-Based Pastes with CFB Fly Ash as an SCM

Buildings
The incorporation of circulating fluidized bed (CFB) fly ash into self-leveling cement-based (SLC) paste production presents significant environmental advantages. However, its addition deteriorates the fresh properties of the paste, posing challenges for
Chun-Ran Wu, Wei Tang, Yan-Lin Huo, Bao-Jian Zhan, Shi-Cong Kou   +4 more
doaj   +1 more source