Results 51 to 60 of about 40,790 (312)

SUMOylation of NaV1.2 channels mediates the early response to acute hypoxia in central neurons. [PDF]

, 2016
The mechanism for the earliest response of central neurons to hypoxia-an increase in voltage-gated sodium current (INa)-has been unknown. Here, we show that hypoxia activates the Small Ubiquitin-like Modifier (SUMO) pathway in rat cerebellar granule ...
Goldstein, Steve An, Marks, Jeremy D, Plant, Leigh D   +2 more
core   +2 more sources

Loading history changes the morphology and compressive force-induced expression of receptor activator of nuclear factor kappa B ligand/osteoprotegerin in MLO-Y4 osteocytes [PDF]

PeerJ, 2020
Background In this study, we investigated the effect of the mechanical loading history on the expression of receptor activator of nuclear factor kappa B ligand (RANKL) and osteoprotegerin (OPG) in MLO-Y4 osteocyte-like cells.
Ziyi Wang, Yao Weng, Yoshihito Ishihara, Naoya Odagaki, Ei Ei Hsu Hlaing, Takashi Izawa, Hirohiko Okamura, Hiroshi Kamioka   +7 more
doaj   +2 more sources

Live cell imaging reveals focal adhesions mechanoresponses in mammary epithelial cells under sustained equibiaxial stress [PDF]

, 2018
Mechanical stimuli play a key role in many cell functions such as proliferation, differentiation and migration. In the mammary gland, mechanical signals such as the distension of mammary epithelial cells due to udder filling are proposed to be directly ...
Bianchi, Micaela, Burdisso, Juan Eduardo, Gastaldi, Laura Micaela, Pietrasanta, Lia, Sigaut, Lorena, Von Bilderling, Catalina   +5 more
core   +1 more source

Length-dependent disassembly maintains four different flagellar lengths in Giardia. [PDF]

, 2019
With eight flagella of four different lengths, the parasitic protist Giardia is an ideal model to evaluate flagellar assembly and length regulation. To determine how four different flagellar lengths are maintained, we used live-cell quantitative imaging ...
Aurrecoechea, Avidor-Reiss, Avidor-Reiss, Ball, Barker, Berman, Bertiaux, Blaineau, Bradley, Briggs, Brooks, Buchel, Buisson, Chan, Chien, Cole, Cooper, Coyne, Craft, Dawson, Deane, Desai, Ellenberg, Engel, Fai, Gibson, Gourguechon, Hagen, Hao, Hardin, Helenius, Hendel, Hilton, Hoeng, Hunter, Ishikawa, Kozminski, Lechtreck, Lenaghan, Ludington, Ludington, Mangeol, Manning, Marshall, Marshall, McInally, McInally, Meng, Mohapatra, Naoz, Nohynková, Pazour, Pazour, Piao, Reiter, Rosenbaum, Sagolla, Schindelin, Shaner, Sung, Tamm, Vasudevan, Walczak, Wang, Wei, Williams, Wingfield, Wloga, Woessner, Wren   +69 more
core   +2 more sources

Calibrating evanescent-wave penetration depths for biological TIRF microscopy

, 2019
Roughly half of a cells proteins are located at or near the plasma membrane. In this restricted space the cell senses its environment, signals to its neighbors and ex-changes cargo through exo- and endocytotic mechanisms.
Becherer, Ute, Brunstein, Maia, Oheim, Martin, Salomon, Adi, Weissman, Adam   +4 more
core   +1 more source

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. [PDF]

, 2017
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are age-related neurodegenerative disorders with shared genetic etiologies and overlapping clinical and pathological features. Here we studied a novel ALS/FTD family and identified the
Annu, Kavya, Baker, Matt, Bigio, Eileen, Boylan, Kevin B., Caselli, Richard J., Dickson, Dennis W., Finger, Elizabeth, Fryer, John D., Graff-Radford, Neill R., Hirsch-Reinshagen, Veronica, Hsiung, Ging-Yuek R., Kato, Masato, Keith, Julia, Kim, Hong Joo, Krieger, Charles, Kurti, Aishe, Lacomis, David, Lippa, Carol, Mackenzie, Ian R., Matchett, Billie J., Messing, James, Mesulam, Marsel, Mittag, Tanja, Murray, Melissa E., Nicholson, Alexandra M., Perkerson, Ralph B., Petersen, Ronald C., Petrucelli, Leonard, Pottier, Cyril, Purice, Maria D., Rademakers, Rosa, Rogaeva, Ekaterina, Roos, Raymond P., Sarkar, Mohona, Stewart, Heather, Taylor, J. Paul, Temirov, Jamshid, Weintraub, Sandra, Wszolek, Zbigniew K., Zinman, Lorne, Zivkovic, Sasha A., Züchner, Stephan   +41 more
core   +2 more sources

Fluorescence Recovery after Photobleaching in Ultrathin Polymer Films

Macromolecular Chemistry and Physics, 2017
AbstractFluorescence recovery after photobleaching (FRAP) is a widely used technique to study the transport of molecules in biological systems. Recently, FRAP has been used to study molecular transport in polyelectrolyte multilayers (PEMs). Through numerical simulations verified by experiments, it is shown that the FRAP behavior of PEM films in an ...
Praneet Prakash, Suman Pahal, Manoj Varma   +2 more
openaire   +2 more sources

Sequence determinants of in cell condensate morphology, dynamics, and oligomerization as measured by number and brightness analysis

Cell Communication and Signaling, 2021
Background Biomolecular condensates are non-stoichiometric assemblies that are characterized by their capacity to spatially concentrate biomolecules and play a key role in cellular organization.
Ryan J. Emenecker, Alex S. Holehouse, Lucia C. Strader   +2 more
doaj   +1 more source

Differences in protein mobility between pioneer versus follower growth cones [PDF]

, 2007
Navigating growth cones need to integrate, process and respond to guidance signals, requiring dynamic information transfer within and between different compartments.
Bak, Bovolenta, Bovolenta, Brown, Campbell, Cheutin, Chitnis, Dent, Festenstein, Flanagan, Forscher, Gallo, Higashijima, Klonis, Lippincott-Schwartz, Mastick, McConnell, Meng, Myers, Nehls, Phair, Popov, Solnica-Krezel, Tessier-Lavigne, White, Wilson   +25 more
core   +3 more sources

Fluorescence recovery after photobleaching: direct measurement of diffusion anisotropy [PDF]

Biomechanics and Modeling in Mechanobiology, 2020
Fluorescence recovery after photobleaching (FRAP) is a widely used technique for studying diffusion in biological tissues. Most of the existing approaches for the analysis of FRAP experiments assume isotropic diffusion, while only a few account for anisotropic diffusion. In fibrous tissues, such as articular cartilage, tendons and ligaments, diffusion,
Hashlamoun, Kotaybah, Abusara, Ziad, Ramirez Torres, Ariel, Grillo, Alfio, Herzog, Walter, Federico, Salvatore   +5 more
openaire   +3 more sources