Results 41 to 50 of about 328,963 (317)

First Clinical Results of Fluorescence Lifetime-enhanced Tumor Imaging Using Receptor-targeted Fluorescent Probes [PDF]

, 2022
Rahul Pal, Marisa E. Hom, Nynke S. van den Berg, Thinzar M. Lwin, Yujin Lee, Andrey Prilutskiy, William C. Faquin, Eric Yang, Srinivas Vinod Saladi, Mark A. Varvares, Eben L. Rosenthal, Anand T. N. Kumar   +11 more
openalex   +1 more source

Crosstalk between the ribosome quality control‐associated E3 ubiquitin ligases LTN1 and RNF10

FEBS Letters, EarlyView.
Loss of the E3 ligase LTN1, the ubiquitin‐like modifier UFM1, or the deubiquitinating enzyme UFSP2 disrupts endoplasmic reticulum–ribosome quality control (ER‐RQC), a pathway that removes stalled ribosomes and faulty proteins. This disruption may trigger a compensatory response to ER‐RQC defects, including increased expression of the E3 ligase RNF10 ...
Yuxi Huang, Satoshi Hashimoto, Sota Ito, Chisato Kikuguchi, Miho Hoshi, Kiyoshi Yamaguchi, Yoichi Furukawa, Toru Suzuki, Toshifumi Inada   +8 more
wiley   +1 more source

Homologous cholinergic fluorescent probes. Synthesis and fluorescence properties [PDF]

FEBS Letters, 1978
The advantages of using specifically designed fluorescent molecules to probe ligand binding sites on proteins, have been recognised [1]. Cholinesterases [2-4], acetylcholine receptor rich fragments from Torpedo marmorata[5,6] and an acetylcholine binding lipoprotein [7] have been studied using fluorescent trialkylammonium ligands.
Narayanan, R, Balaram, P
openaire   +3 more sources

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Fluorescent Probes for Biological Imaging [PDF]

BioMed Research International, 2016
Owing to the high sensitivity, high resolution, and the wealth of contrast mechanisms, fluorescence imaging is the most versatile and widely used visualization modality to study the structure and function of biological systems and the molecular process in living organisms without perturbing them.
Xuanjun Zhang, Yupeng Tian, Jiangbo Yu, Zhen Yuan   +3 more
openaire   +2 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

FEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

The Detection of Lymph Node Metastasis Metastases Using a Near-Infrared Fluorescent Probe Based on Tumor-Targeted Monoclonal Antibody Antibodies Specific: A Prospective Study in a Nude Mouse Model

Clinical and Experimental Obstetrics & Gynecology
Background: To identify the metastatic lymph nodes and remove them accurately, the fluorescent surgical navigation ability of the ovarian cancer-specific fluorescent probe COC183B2-800 was assessed to verify the metastatic lymph nodes ...
Huarui Yang, Yijun Zhang, Chongyuan Zhu, Yi Zhu, Xuelian Song, Xiaohong Chang, Yi Li   +6 more
doaj   +1 more source

Construction of mercury ion fluorescence system in water samples and art materials and fluorescence detection method for rhodamine B derivatives

Green Processing and Synthesis, 2022
At present, the research on fluorescent molecular probe has become a hot topic in the field of environmental science, chemical materials, medicine, and other fields.
Wang Zhankun, Hu Yanqiu, Zhou Xiaoxuan, Lv Yuguang   +3 more
doaj   +1 more source

Fluorescent Probes of Biological Membranes [PDF]

Proceedings of the National Academy of Sciences, 1970
Fluorescent and phosphorescent probes that have readily interpretable emission properties can be specifically inserted into biological macromolecules to reveal facets of their structure and dynamics: (1) Proximity . Singlet-singlet and triplet-singlet energy transfer can serve as spectroscopic rulers in the 10-65 Å ...
A S, Waggoner, L, Stryer
openaire   +2 more sources