Results 211 to 220 of about 64,958 (266)
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ChemBioChem, 2014
No longer in-F-able: fluorine building blocks can be used in polyketide biosynthesis. This represents a more flexible approach to organofluorines than the traditional use of fluorinated starter units in multistep organic syntheses, and will hopefully increase the number of compounds available for drug development.
Klopries, Stephan +3 more
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No longer in-F-able: fluorine building blocks can be used in polyketide biosynthesis. This represents a more flexible approach to organofluorines than the traditional use of fluorinated starter units in multistep organic syntheses, and will hopefully increase the number of compounds available for drug development.
Klopries, Stephan +3 more
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Electrophilic Aromatic Fluorination with Fluorine: meta‐Directed Fluorination of Anilines.
ChemInform, 2005AbstractFor Abstract see ChemInform Abstract in Full Text.
J.P. Alric +3 more
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α-Fluorination of carbonyls with nucleophilic fluorine
Nature Chemistry, 2019Given the unique properties of fluorine, and the ability of fluorination to change the properties of organic molecules, there is significant interest from medicinal chemists in innovative methodologies that enable the synthesis of new fluorinated motifs.
Pauline Adler +5 more
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Organic & Biomolecular Chemistry, 2022
Fluorinated fluorenones can be elaborated to polyhalogenated dibenzochrysenes in 4 steps.
Cody F. Dickinson +2 more
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Fluorinated fluorenones can be elaborated to polyhalogenated dibenzochrysenes in 4 steps.
Cody F. Dickinson +2 more
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Dalton Transactions, 2015
Welcome to this themed issue of Dalton Transactions entitled ‘Fluorine’.
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Welcome to this themed issue of Dalton Transactions entitled ‘Fluorine’.
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Fluorinations Not Using Fluorine Gas
2022The introduction of fluorine in pharmaceuticals and agrochemicals can be highly advantageous. The substitution of one or just a few hydrogen atoms by fluorine can dramatically alter a compounds acidity/basicity and lipophilicity, which may result in an improvement of its biological and/or pharmaceutical properties.
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Investigation of fluorination by atomic fluorine
Journal of Fluorine Chemistry, 1991Abstract The process of fluorination of uranium tetrafluoride by atomic fluorine has been investigated on a closed circulation facility. The concentration of atomic fluorine in the flux was estimated using thermocouples. The ratio of fluorination at different distances from the atomic fluorine source was determined.
P.E. Erilov, V.V. Titov, V.F. Serik
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Journal of Drug Targeting, 1994
Stable fluorinated vesicles--i.e. vesicles with a hydrophobic and lipophobic fluorinated film within their bilayer membranes--have been obtained from a variety of neutral, zwitterionic or anionic fluorinated amphiphiles, including single chain phosphocholine derivatives, double-chain phospholipids, glycolipids and glycophospholipids, as well as from ...
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Stable fluorinated vesicles--i.e. vesicles with a hydrophobic and lipophobic fluorinated film within their bilayer membranes--have been obtained from a variety of neutral, zwitterionic or anionic fluorinated amphiphiles, including single chain phosphocholine derivatives, double-chain phospholipids, glycolipids and glycophospholipids, as well as from ...
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Current Pharmaceutical Design, 1970
Abstract: Following the discovery of nalidixic acid in 1962, numerous structural modifications have been made to the quinolone nucleus to increase antimicrobial activit> and improve pharmacokinetic performance. A major advance occured during the 1980\ with the discovery that a fluorine at position-6 conferred broad and potent antimicrobial activity,
M, Kidwai, P, Misra, R, Kumar
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Abstract: Following the discovery of nalidixic acid in 1962, numerous structural modifications have been made to the quinolone nucleus to increase antimicrobial activit> and improve pharmacokinetic performance. A major advance occured during the 1980\ with the discovery that a fluorine at position-6 conferred broad and potent antimicrobial activity,
M, Kidwai, P, Misra, R, Kumar
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Carbohydrate Research, 2000
The synthesis and biological activity of deoxyfluoro nucleosides are reviewed.
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The synthesis and biological activity of deoxyfluoro nucleosides are reviewed.
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