Results 171 to 180 of about 9,550 (296)

HER2‐Targeted AIE Nanotheranostics Overcome SHR‐A1811 Resistance via Immunogenic Pyroptosis and Tumor‐Associated Macrophage Reprogramming in Breast Cancer

Small, EarlyView.
HER2‐targeted AIE780‐A1811 nanoparticles self‐assemble via amide coupling of a mitochondria‐directed photosensitizer with the ADC SHR‐A1811. Upon 660 nm irradiation, they generate ROS, photothermal effects, and controlled drug release, inducing immunogenic pyroptosis and M2‐to‐M1 macrophage reprogramming. This dual action remodels the immunosuppressive
Xiaohong Liu, Nisha Wu, Zaihui Peng, Guozhi Zhang, Lin Ren, Qiuyun Li, Jie Xiao, Jing He, Yuxiuzi Xiao, Li Ma, Yi Zhang, Ying Gong, Xiaowei Qi   +12 more
wiley   +1 more source

Bidirectional Plant‐Microneedle Responses to Guide Biomaterial Design

Small, EarlyView.
We examine bidirectional interactions between plants and polymeric microneedles to develop effective compound delivery strategies. Material chemistry and architecture determine stability in the plant environment, cargo–matrix interactions, and the magnitude and duration of the plant response. Plant microneedles should therefore be designed as a coupled
Sally Shuxian Koh, Meng Li, Kasey Goh, Yunteng Cao, Yangyang Han, Raju Cheerlavancha, Liang Cui, Benedetto Marelli, Daisuke Urano   +8 more
wiley   +1 more source

Urban bats show dietary flexibility in aquatic arthropod consumption at urban and rural waterbodies

Wildlife Biology, EarlyView.
Urban waterbodies are critical for biodiversity and provide feeding grounds for insectivorous bats. Yet, how urbanisation affects bats' food choices at urban waterbodies and the role of emergent aquatic arthropods remain poorly understood. We compared the diet of three urban bat species – Vespadelus vulturnus, Chalinolobus gouldii,and Myotis macropus –
Tanja M. Straka, Melissa E. Carew, Isabel Valenzuela, Stephen R. Griffiths, Pia E. Lentini, Linda F. Lumsden, Rahul Rane, Rodney Ree van der   +7 more
wiley   +1 more source

Assessing genetic diversity in a reintroduced Mediterranean griffon vulture Gyps fulvus population to inform long‐term conservation management

Wildlife Biology, EarlyView.
Reintroductions play a key role in conservation biology. Their long‐term success strongly depends on maximizing the genetic diversity of founders, as well as on ensuring ecological connectivity with adjacent populations. Accordingly, evaluating the conservation status of reintroduced populations to limit the loss of their genetic diversity requires ...
Nicolò Borgianni, Mario Posillico, Lorenzo Attili, Paolo Ciucci, Rita Lorenzini, Luisa Garofalo   +5 more
wiley   +1 more source

Water amount, rather than watering frequency, structures root‐associated microbial communities and their links to plant performance

Functional Ecology, EarlyView.
Read the free Plain Language Summary for this article on the Journal blog. Abstract Climate change is altering both the amount and temporal distribution of precipitation, yet drought is often simplified to a single gradient of water reduction. As a result, how experimentally imposed variation in water amount and watering frequency jointly shape root ...
Gang Yang, Tomáš Dostálek, Zuzana Münzbergová   +2 more
wiley   +1 more source

DNA‐Methylation for Risk‐Stratification of Women Without a Fully Visible Transformation Zone at Colposcopy: A Cross‐Sectional Study

BJOG: An International Journal of Obstetrics &Gynaecology, EarlyView.
ABSTRACT Objective To evaluate the performance of DNA methylation markers for the detection of cervical precancer among screening‐positive older women without a fully visible transformation zone at colposcopy (TZ3). Design Cross‐sectional study. Setting Colposcopy clinics, Central Denmark Region, 2019–2021.
Karen Omann Binderup, Joachim Boers, Line Winther Gustafson, Berit Andersen, Lone Kjeld Petersen, Pinar Bor, Joost Gribnau, Wim G. V. Quint, Henk Van Den Munckhof, Mette Tranberg, Anne Hammer   +10 more
wiley   +1 more source

Effects of bleach on carcass postmortem microbiomes and necrophagous beetle carcass attendance and their internal microbiomes

Journal of Forensic Sciences, EarlyView.
Abstract Forensic entomology, and potentially microbiology in the future, can be used during death investigations to corroborate an estimated time since death. Instances where products are introduced to a cadaver, either in attempt to conceal or by accident, can affect decomposition and succession of associated decomposer taxa (i.e., insects and ...
Kelly A. Waters, Makayla Guenther, Katherine H. Yoskowitz, Audrey Malone, Anthony Grigsby, Bethany G. Mikles, Jennifer L. Pechal, M. Eric Benbow   +7 more
wiley   +1 more source

A quantitative evaluation of forensic sampling tools and extraction methods

Journal of Forensic Sciences, EarlyView.
Abstract Forensic sampling of bodily fluids is commonly performed by means of swabbing and occasionally tape‐lifting. Current research focuses on comparative studies of commercially available swab types, and alternative methods are rarely investigated.
Michel Nunnenkamp, Han Gardeniers, Loes Segerink, Brigitte Bruijns   +3 more
wiley   +1 more source

Gut Microbiota of Gray Snub‐Nosed Monkeys: Adaptation to Seasonal Variations Through Energy Compensation and Thermogenesis

Integrative Zoology, EarlyView.
Based on metagenome‐assembled genomes (MAGs), the gut microbiota of the gray snub‐nosed monkeys recovered 1229 non‐redundant MAGs. The gut microbiota showed an enhanced capacity to produce energy substrates with increased conversion activity of these substrates during winter.
Yue Sun, Mingyi Zhang, Xiaochen Wang, Xiaolong Huang, Yanze Yu, Huijuan Pan, Haibo Li, Lei Shi, Wei Yang, Chen Zhang, Bo Ding, Xun Liu, Jianfeng Li, Changjiang Qian, Boxing Cheng, Chao Zhang, Jingcheng Ran, Ming Li   +17 more
wiley   +1 more source

High-speed, FPGA-based photon-counting fluorometer with high data-gathering efficiency

, 2017
T. Iwata, T. Mizuno
semanticscholar   +1 more source